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IL-27: Structure, Regulation, and Variability

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Interleukin-27: Biological Properties and Clinical Application

Part of the book series: SpringerBriefs in Immunology ((BRIEFSIMMUN))

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Abstract

Interleukin 27 (IL-27) is a novel cytokine secreted by stimulated antigen-presenting cells. Initial studies on the biology of IL-27 provided evidence for its role in the initiation of Th1 responses; however, subsequent work has indicated that IL-27 has broad stimulatory as well as inhibitory effects on Th1, Th2, Th17, Treg, and Tr1 subsets of T cells as well as NK cells and B cells. Together with other members of IL-12 family, it orchestrates initiation of inflammatory processes and sustains immune polarization. IL-27 is a heterodimer composed of IL-27p28 and EBI3. EBI3 has been found to form a biologically active complex with IL-12p35 (known as IL-35) and IL-23p19 (known as IL-39), while IL-27p28 can form a dimer with CLF. IL-27p28 has also its own inherent activity and can act on its own as IL-30. Here, we have discussed the variability of IL-27 gene, protein structure of IL-27 and its receptor, and molecular mechanisms regulating IL-27 expression.

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  1. Chair of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

    Marek Jankowski

  2. Department of Gene Therapy, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

    Tomasz Wandtke

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Jankowski, M., Wandtke, T. (2016). IL-27: Structure, Regulation, and Variability. In: Interleukin-27: Biological Properties and Clinical Application. SpringerBriefs in Immunology. Springer, Cham. https://doi.org/10.1007/978-3-319-39664-4_1

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