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Efflux-Mediated Antimicrobial Resistance in Bacteria pp 307–328Cite as

Antimicrobial Resistance and Drug Efflux Pumps in Vibrio and Legionella

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Abstract

The two genera, Vibrio and Legionella, are associated with aquatic environments and cause severe illnesses such as cholera and legionellosis, respectively. The representative species, Vibrio cholerae, Vibrio parahaemolyticus, and Legionella pneumophila, are generally susceptible to a range of antimicrobial agents, but their resistance to antimicrobials can be readily selected after exposure to antimicrobial agents. The genomes of these species contain a large number of genes encoding proven and putative drug efflux transporters (including the prototypical NorM drug exporter identified in Vibrio spp.), some of which have been demonstrated to play an important role in intrinsic resistance to structurally unrelated antimicrobials as well as to involve in other functions such as virulence. However, the expressional regulation of these drug efflux pumps and their contribution to acquired antimicrobial resistance remain a key area for future research. This chapter provides an overview of antimicrobial resistance in Vibrio and Legionella with a focus on current understanding of drug efflux pumps in resistance and other functions.

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Acknowledgments

The views expressed in this chapter do not necessarily reflect those of Xian-Zhi Li’s affiliation, Health Canada.

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Authors and Affiliations

  1. Department of Microbiology, School of Pharmacy, Aichi Gakuin University, Nagoya, Aichi, Japan

    Yuji Morita

  2. Human Safety Division, Veterinary Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada

    Xian-Zhi Li

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  1. Yuji Morita
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Correspondence to Yuji Morita .

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Editors and Affiliations

  1. Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada

    Xian-Zhi Li

  2. U.S. Food and Drug Administration, Laurel, Maryland, USA

    Christopher A. Elkins

  3. University of Oklahoma, Norman, Oklahoma, USA

    Helen I. Zgurskaya

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Morita, Y., Li, XZ. (2016). Antimicrobial Resistance and Drug Efflux Pumps in Vibrio and Legionella . In: Li, XZ., Elkins, C., Zgurskaya, H. (eds) Efflux-Mediated Antimicrobial Resistance in Bacteria. Adis, Cham. https://doi.org/10.1007/978-3-319-39658-3_12

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