The Role of Folliculo-Luteal Insufficiency in the Emergence of Random Chromosomal Abnormalities

  • György Siklósi


It is a proven fact that about 50 % of pregnancy losses are caused by randomly occurring, mainly numerical chromosomal abnormalities (CA) that emerge during oogenesis (sometimes during spermiogenesis). Based on this, the normalisation of folliculo-luteal function (FLF) and placentation – if this did not influence the emergence of CAs – would be able to decrease the prevalence of miscarriage by half at most, while the actual miscarriage rate is only a fraction of this number.

In recurrent miscarriage, the normalisation of FLF decreased the occurrence of miscarriage by an order of magnitude compared to the untreated control group (39.4 and 4.5 %). Even if CAs were the cause of every abortion with physiological FLF, the incidence of CAs decreased to one-quarter of the expected 19.7 % (50 %). In case of unexplained infertility (UI), the prevalence of miscarriage was 41.2 % in untreated patients and 3.2 % with physiological FLF, which is less than one-sixth of the expected 20.6 %.

This decline is even more dramatic in patients over 35 years of age, where CAs are the most common cause of abortion. In recurrent miscarriage patients with an age of ≥35 years, the miscarriage rate was 54.5 % in the untreated group and 4.7 % with physiological FLF. Miscarriage rates in the untreated and physiological group of ≥35 years with UI were 65.2 and 6.9 % (Chaps. 5 and 6).

In patients with habitual abortion, the occurrence of miscarriage was 97 % (70/72) with confirmed FLF insufficiency and 4.5 % (28/627) with physiological FLF. Our results regarding UI were similar: pregnancy loss occurred in 96 % (47/49) with insufficient FLF and in 3.2 % (27/835) with physiological FLF.

These findings can only be interpreted if we assume that the normalisation of folliculogenesis dramatically decreases the emergence of random, mainly numerical CAs.


Granulosa Cell Pregnancy Loss Meiotic Division Mitotic Division Miscarriage Rate 
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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • György Siklósi
    • 1
  1. 1.Semmelweis University Second Department of Obstetrics and GynecologyBudapestHungary

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