The Beneficial Effects of Preconceptional Normalisation of Folliculo-Luteal Function on Reproduction

  • György Siklósi


We demonstrated the crucial role of folliculo-luteal function (FLF) in pregnancy outcome in the previous chapters. As a simple method of normalising FLF prior to conception is available, we can positively influence pregnancy outcome. To assess the advantages of FLF normalisation in patients treated for unexplained infertility (UI), we compared the outcomes of pregnancies conceived with physiological FLF (N = 638) with the national statistical data.

With physiological FLF, the likelihood of giving birth is almost four times higher (95.0 and 83.4 %; odds ratio/OR, 3.7), and the prospect of miscarriage is reduced by five times (15.1 and 3.4 %; OR, 4.9) compared to the national average. Physiological FLF gives rise to a 15-fold increase (75.8 and 92.3 %; OR, 14.8) in the occurrence of singular, mature and eutrophic births, while the prevalence of preterm birth (0.7 and 9.5 %; OR, 14.8), IUGR (0.7 and 10.1 %; OR, 15.8) and preeclampsia (0 and 3 %; OR, 14.8) is 15 times lower than with spontaneously conceived pregnancies. The likelihood of pregnancy complications occurring (including miscarriage and extrauterine pregnancy) is 5.4 % and 39 %, respectively, in the two groups. Beyond the drastically decreased prevalence of preterm births and growth-retarded births, the newborn characteristics are also significantly (p < 0.001) better in these cases than without treatment. Every newborn but one (0.17 %) was born after the 34th week and weighed over 2000 g.

Twin births occur 4.1 times more often with physiological FLF, and their pregnancy outcome is significantly (p < 0.001) better than in spontaneous conception: the prevalence of newborns weighing under 1500 g is 0 % and 11 %, respectively, and under 2000 g 7.5 % and 27 %, respectively.

By FLF normalisation we can establish the birth of invaluable, new, healthy generations.


Preterm Birth Pregnancy Outcome Clomiphene Citrate Adverse Pregnancy Outcome Recurrent Miscarriage 
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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • György Siklósi
    • 1
  1. 1.Semmelweis University Second Department of Obstetrics and GynecologyBudapestHungary

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