Abstract
Beside a general eIF4E gene version which allows for regular cap-dependent translation, yeast species show a remarkable variety of eIF4E genes which might exert specialized functions such as to downregulate eIF4E-activity or even repress specific mRNAs. Additionally, 4E-BPs (eIF4E binding proteins) modulate mRNA activity and might help certain yeast species to adapt to a large variation of possible stress conditions. In that sense, lower eukaryotes reflect the variety of regulatory mechanism for cap-dependent translation encountered among other eukaryotes.
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This work was supported by Swiss National Foundation grant 31003A_146722/1.
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Ross, D., Altmann, M. (2016). eIF4Es and Their Interactors from Yeast Species. In: Hernández, G., Jagus, R. (eds) Evolution of the Protein Synthesis Machinery and Its Regulation. Springer, Cham. https://doi.org/10.1007/978-3-319-39468-8_7
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