Translation Elongation and Termination: Are They Conserved Processes?

  • Sandra Eltschinger
  • Peter Bütikofer
  • Michael AltmannEmail author


In this chapter, we focus on the function and evolution of translation elongation and termination mechanisms. We review the current knowledge on the properties of eukaryotic elongation and termination factors and compare them to their prokaryotic orthologues. Additionally, we describe posttranslational modifications of elongation factors and discuss their possible roles in translation. Although several features of elongation and termination factors are strictly conserved among all domains of life, notable differences occur between bacteria, archaea and eukaryotes.


Stop Codon Release Factor Translation Termination SECIS Element Peptide Bond Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by Swiss National Foundation grants 31003A_146722/1 (M. Altmann) and 31003A_149353/1 (P. Bütikofer).


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Sandra Eltschinger
    • 1
  • Peter Bütikofer
    • 1
  • Michael Altmann
    • 1
    Email author
  1. 1.Institute of Biochemistry and Molecular Medicine (IBMM)BernSwitzerland

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