Evolution of tRNAs Was Driven by Entropic Forces

  • Marco V. JoséEmail author
  • Gabriel S. Zamudio
  • Sávio Torres de Farías


A succinct review of the role of tRNA and aminoacyl-tRNA synthetases in the origin of the genetic code is provided. The entropy per each site of tRNA molecules is calculated. An entropy profile is obtained for each type of tRNA. When the average of entropy per site of the tRNAs is calculated according to their synthetases, a mirror symmetry is obtained. We conclude that the two codes for amino-acylation and codon-anticodon interactions arose concomitantly, so that these two codes were originally one and the same.



MVJ was financially supported by PAPIIT-IN224015, UNAM, México.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Marco V. José
    • 1
    Email author
  • Gabriel S. Zamudio
    • 1
  • Sávio Torres de Farías
    • 2
  1. 1.Theoretical Biology Group, Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoMexico CityMexico
  2. 2.Centro de Ciencias Exactas y NaturalesUniversidade Federal da ParaíbaJoão PessoaBrazil

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