Abstract
Medullary thyroid carcinoma (MTC) is a rare form of thyroid carcinoma. The hereditary nature and central role for surgical management has been reviewed in other chapters of this text. The data which guide the use of external beam radiotherapy in MTC is largely based on institutional series due to the rarity of MTC. Surgical resection is the primary management modality and there is no role for 131Iodine as a form of radiotherapy. This chapter will review the role of EBRT in improving locoregional control in patient with MTC and will review the radiotherapy techniques used in modern management, namely intensity-modulated radiotherapy (IMRT).
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References
Brierley J, Tsang R, Simpson WJ, Gospodarowicz M, Sutcliffe S, Panzarella T. Medullary thyroid cancer: analyses of survival and prognostic factors and the role of radiation therapy in local control. Thyroid Official J Am Thyroid Assoc. 1996;6(4):305–10 Epub 1996/08/01.
Schwartz DL, Rana V, Shaw S, Yazbeck C, Ang KK, Morrison WH, et al. Postoperative radiotherapy for advanced medullary thyroid cancer–local disease control in the modern era. Head Neck. 2008;30(7):883–8 Epub 2008/01/24.
Call JA, Caudill JS, McIver B, Foote RL. A role for radiotherapy in the management of advanced medullary thyroid carcinoma: the mayo clinic experience. Rare Tumors. 2013;5(3):e37. Epub 2013/11/02.
Fersht N, Vini L, A’Hern R, Harmer C. The role of radiotherapy in the management of elevated calcitonin after surgery for medullary thyroid cancer. Thyroid Official J Am Thyroid Assoc. 2001;11(12):1161–8 Epub 2002/08/21.
Terezakis SA, Lee KS, Ghossein RA, Rivera M, Tuttle RM, Wolden SL, et al. Role of external beam radiotherapy in patients with advanced or recurrent nonanaplastic thyroid cancer: memorial Sloan-kettering cancer center experience. Int J Radiat Oncol Biol Phys. 2009;73(3):795–801 Epub 2008/08/05.
Martinez SR, Beal SH, Chen A, Chen SL, Schneider PD. Adjuvant external beam radiation for medullary thyroid carcinoma. J Surg Oncol. 2010;102(2):175–8 Epub 2010/07/22.
Goltzman D, Potts JT Jr, Ridgway RC, Maloof F. Calcitonin as a tumor marker. Use of the radioimmunoassay for calcitonin in the postoperative evaluation of patients with medullary thyroid carcinoma. N Engl J Med. 1974;290(19):1035–9 Epub 1974/05/09.
Wells SA Jr, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, et al. Revised American thyroid association guidelines for the management of medullary thyroid carcinoma. Thyroid Official J Am Thyroid Assoc. 2015;25(6):567–610 Epub 2015/03/27.
Perros P, Boelaert K, Colley S, Evans C, Evans RM, Gerrard Ba G, et al. Guidelines for the management of thyroid cancer. Clin Endocrinol. 2014;81(Suppl 1):1–122 Epub 2014/07/06.
Kam MK, Leung SF, Zee B, Chau RM, Suen JJ, Mo F, et al. Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J Clin Oncol Official J Am Soc Clin Oncol. 2007;25(31):4873–9 Epub 2007/11/01.
Lee N, Harris J, Garden AS, Straube W, Glisson B, Xia P, et al. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol Official J Am Soc Clin Oncol. 2009;27(22):3684–90 Epub 2009/07/01.
Chow E, Wong R, Hruby G, Connolly R, Franssen E, Fung KW, et al. Prospective patient-based assessment of effectiveness of palliative radiotherapy for bone metastases. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2001;61(1):77–82 Epub 2001/10/02.
Nguyen TD, Chassard JL, Lagarde P, Cutuli B, Le Fur R, Reme-Saumon M, et al. Results of postoperative radiation therapy in medullary carcinoma of the thyroid: a retrospective study by the French Federation of Cancer Institutes–the Radiotherapy Cooperative Group. Radiother Oncol J Eur Soc Ther Radiol Oncol. 1992;23(1):1–5 Epub 1992/01/01.
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Giuliani, M.E., Brierley, J. (2016). Medullary Thyroid Cancer: The Role of External Beam Therapy. In: Wang, T., Evans, D. (eds) Medullary Thyroid Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-39412-1_14
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DOI: https://doi.org/10.1007/978-3-319-39412-1_14
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