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Urolithiasis and Nephrocalcinosis

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Book cover Pediatric Urogenital Radiology

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Urolithiasis and nephrocalcinosis (NC) are the two types of calcification associated with the urinary tract. Urolithiasis is macroscopic calcification in the urinary collecting system. Urinary stones are composed out of crystal agglomerations, sometimes mixed with proteins. Stones are formed on the renal papillae by retention of lithogenic particles (Randall’s plaques), either by obstruction or by adherence to damaged renal epithelium (Coe et al. 2010; Evan et al. 2007; Randall 1937). This takes place when urine is supersaturated with regard to stone promoting factors, e.g. increased calcium or oxalate excretion, or because the inhibitor activity is reduced, e.g. low citrate excretion (Karlowicz and Adelman 1995; Verkoelen et al. 1998).

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References

  • Akhan O, Özmen MN, Coskun M, Özen S, Akata D, Saatci Ü (1995) Systemic oxalosis: pathognomonic renal and specific extrarenal findings on US and CT. Pediatr Radiol 25:15–16

    Article  PubMed  CAS  Google Scholar 

  • Alon US (1997) Nephrocalcinosis. Pediatrics 9:160–165

    CAS  Google Scholar 

  • Alon US, Scagliotti D, Garola RE (1994) Nephrocalcinosis and nephrolithiasis in infants with congestive heart failure treated with furosemide. J Pediatr 125:149–151

    Article  PubMed  CAS  Google Scholar 

  • Ammenti A, Neri E, Agistri R et al (2006) Idiopathic hypercalciuria in infants with renal stones. Pediatr Nephrol 21(12):1901–1903

    Article  PubMed  Google Scholar 

  • Arikyants N, Sarkissian A, Hesse A et al (2007) Xanthinuria type I – a rare cause of urolithiasis. Pediatr Nephrol 22(2):310–314

    Article  PubMed  Google Scholar 

  • Avni EF, Spehl-Robberecht M, Lebrun D, Gomes H, Garel L (1983) Pathologie Tubulaire Aiguë Transitoire Chez Le Nourrisson: Aspect Échographique Charactéristique. Ann Radiol 26:175–182

    PubMed  CAS  Google Scholar 

  • Basaklar AC, Kale N (1991) Experiences with childhood urolithiasis (report of 196 cases). Br J Urol 67:203–205

    Article  PubMed  CAS  Google Scholar 

  • Beck BB, Baasner A, Buescher A et al (2013) Novel findings in patients with primary hyperoxaluria type III and implications for advanced molecular testing strategies. Eur J Hum Genet 21(2):162–172

    Article  PubMed  CAS  Google Scholar 

  • Belostosky R, Seboun E, Idelson GH, Milliner DS, Becker-Cohen R, Rinat C (2010) Mutations in DHDPSL are responsible for primary hyperoxaluria type III. Am J Hum Genet 87:392–399

    Article  CAS  Google Scholar 

  • Berdon WE, Schwartz RH, Becker J, Baker DH (1969) Tamm-Horsfall proteinuria. Radiology 92:714–722

    Article  PubMed  CAS  Google Scholar 

  • Boddy SA, Duffy PG, Barratt TM, Whitfield HN (1988) Hyperoxaluria and renal calculi in children. The role of extracorporeal shock wave lithotripsy. Proc R Soc Med 81:604–605

    CAS  Google Scholar 

  • Breslau NA (1994) Pathogenesis and management of hypercalciuric nephrolithiasis. Miner Electrolyte Metab 20(6):328–339

    PubMed  CAS  Google Scholar 

  • Bruwer A (1979) Primary renal calculi: Anderson-Carr-Randall progression? AJR Am J Roentgenol 132:751–758

    Article  PubMed  CAS  Google Scholar 

  • Brühl P, Hesse A, Gu KLR (1987) Harnsteinerkrankungen im Kindesalter: ƒtiologie, Diagnostik, Therapie und Metaphylaxe. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart

    Google Scholar 

  • Bruziere J, Roubach L (1981) Urinary lithiasis in children. Eur J Urol 7:134–135

    Article  Google Scholar 

  • Buckalew VM Jr (1989) Nephrolithiasis in renal tubular acidosis. J Urol 141(3 Pt 2):731–737

    Article  PubMed  Google Scholar 

  • Burton EM, Hanna JD, Mercado-Deane MG (1995) Nephrocalcinosis in a child with autosomal dominant polycystic kidney disease and a prolapsing ectopic ureterocele. Pediatr Radiol 25:462–465

    Article  PubMed  CAS  Google Scholar 

  • Cameron JS, Moro F, Simmonds HA (1993) Gout, uric acid and purine metabolism in paediatric nephrology. Pediatr Nephrol 7(1):105–118

    Article  PubMed  CAS  Google Scholar 

  • Cameron MA, Sakhaee K, Moe OW (2005) Nephrolithiasis in children. Pediatr Nephrol 20(11):1587–1592

    Article  PubMed  Google Scholar 

  • Campfield T, Braden G (1989) Urinary oxalate excretion by very low birth weight infants receiving parenteral nutrition. Pediatrics 84(5):860–863

    PubMed  CAS  Google Scholar 

  • Cebellos-Picot I, Perignon JL, Hamet M, Daudon M, Kamoun P (1992) 2.8 dihydroxyadenine urolithiasis, an underdiagnosed disease. Lancet 339:1050–1051

    Article  Google Scholar 

  • Choi Y, Koo JW, Ha IS et al (1993) Partial hypoxanthine-guanine phosphoribosyl transferase deficiency in two Korean sisters – a new mutation. Pediatr Nephrol 7:739–740

    Article  PubMed  CAS  Google Scholar 

  • Chow GK, Streem SB (1996) Medical treatment of cystinuria: results of contemporary clinical practice. J Urol 156:1576–1578

    Article  PubMed  CAS  Google Scholar 

  • Cochat P, Rumsby G (2013) Primary hyperoxaluria. N Engl J Med 369(7):649–658. doi:10.1056/NEJMra1301564

    Article  PubMed  CAS  Google Scholar 

  • Cochat P, Hulton SA, Acquaviva C et al (2012) Primary hyperoxaluria type 1: indications for screening and guidance for diagnosis and treatment. Nephrol Dial Transplant 27(5):1729–1736

    Article  PubMed  CAS  Google Scholar 

  • Coe FL, Parks JH, Asplin JR (1992) The pathogenesis and treatment of kidney stones. N Engl J Med 327:1141–1152

    Article  PubMed  CAS  Google Scholar 

  • Coe FL, Evan AP, Worcester EM et al (2010) Three pathways for human kidney stone formation. Urol Res 38(3):147–160

    Article  PubMed  PubMed Central  Google Scholar 

  • Cote G, Jequier S, Kaplan P (1989) Increased renal medullary echogenicity in patients with Williams syndrome. Pediatr Radiol 19:481–483

    Article  PubMed  CAS  Google Scholar 

  • Cramer B, Husa L, Pushpanathan C (1998a) Nephrocalcinosis in rabbits – correlation of ultrasound, computed tomography, pathology and renal function. Pediatr Radiol 28:9–13

    Article  PubMed  CAS  Google Scholar 

  • Cramer B, Husa L, Pushpanathan C (1998b) Pattern and permanence of phosphate-induced nephrocalcinosis in rabbits. Pediatr Radiol 28:14–19

    Article  PubMed  CAS  Google Scholar 

  • Cramer BC, Ozere R, Andrews W (1990) Renal stone formation following medical treatment of renal candidiasis. Pediatr Radiol 21:43–44

    Article  PubMed  CAS  Google Scholar 

  • Cregeen DP, Rumsby G (1999) Recent developments in our understanding of primary hyperoxaluria type 2. J Am Soc Neprol 10:348–350

    Google Scholar 

  • Damiani D, Aguiar CH, Bueno VS et al (1998) Primary hyperparathyroidism in children: patient report and review of literature. J Pediatr Endocrinol Metab 11:83–86

    PubMed  CAS  Google Scholar 

  • Danpure CJ (1989) Recent advances in the understanding, diagnosis and treatment of primary hyperoxaluria type I. J Inherit Metab Dis 12:210–224

    Article  PubMed  CAS  Google Scholar 

  • Danpure CJ (2000) Genetic disorders and urolithiasis. Urol North Clin Am 27:287–299

    Article  PubMed  CAS  Google Scholar 

  • Daudon M, Jungers P, Bazin D (2008) Peculiar morphology of stones in primary hyperoxaluria. N Engl J Med 359:100–102

    Article  PubMed  CAS  Google Scholar 

  • Davies M (1989) High dose vitamin D therapy: indications, benefits and hazards. Int J Vitam Nutr Res Suppl 30:81–86

    PubMed  CAS  Google Scholar 

  • Dello Strologo L, Pras E, Pontesilli C et al (2002) Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification. J Am Soc Nephrol 13(10):2547–2553

    Article  PubMed  Google Scholar 

  • De Santo NG, Iorio BD, Capasso G et al (1992) Population based data on urinary excretion of calcium, magnesium, oxalate, phosphate and uric acid in children from Cimitile (southern Italy). Pediatr Nephrol 6:149–157

    Article  PubMed  Google Scholar 

  • Dick PT, Shuckett BM, Tang B, Daneman A, Kooh SW (1999) Observer reliability in grading nephrocalcinosis on ultrasound examinations in children. Pediatr Radiol 29:68–72

    Article  PubMed  CAS  Google Scholar 

  • Downing GJ, Egelhoff JC, Daily DK, Alon U (1991) Furosemide-related renal calcifications in the premature infant. Pediatr Radiol 21:563–565

    Article  PubMed  CAS  Google Scholar 

  • Durkee CT, Balcom A (2006) Surgical management of urolithiasis. Pediatr Clin North Am 53:465–477

    Article  PubMed  Google Scholar 

  • Dyer RB, Chen MYM, Zagoria RJ (1998) Abnormal calcifications in the urinary tract. Radiographics 18:1405–1424

    Article  PubMed  CAS  Google Scholar 

  • Dyer RB, Zagoria RJ (1992) Radiological patterns of mineralization as predictor of urinary stone etiology, associated pathology, and therapeutic outcome. J Stone Dis 4:272–282

    PubMed  CAS  Google Scholar 

  • El-Damanhoury H, Bürger R, Hohenfellner R (1991) Surgical aspects of urolithiasis in children. Pediatr Nephrol 5:339–347

    Article  PubMed  CAS  Google Scholar 

  • Evan AP, Coe FK, Lingeman JE et al (2005) Insights on the pathology of kidney stone formation. Urol Res 33:383–389

    Article  PubMed  Google Scholar 

  • Evan AP, Lingeman J, Coe F et al (2007) Renal histopathology of stone-forming patients with distal renal tubular acidosis. Kidney Int 71(8):795–801

    Article  PubMed  CAS  Google Scholar 

  • Font-Llitjos M, Jimenez-Vidal M, Bisceglia L et al (2005) New insights into cystinuria: 40 new mutations, genotype-phenotype correlation, and digenic inheritance causing partial phenotype. J Med Genet 42:58–68

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Forget S, Patriquin HB, Dubois J, Lafortune M, Merouani A, Paradis K, Russo P (1999) The kidney in children with tyrosinemia: sonographic, CT and biochemical findings. Pediatr Radiol 29:104–108

    Article  PubMed  CAS  Google Scholar 

  • Fourman J (1959) Two distinct forms of experimental nephrocalcinosis in the rat. Br J Exp Pathol 60:463–464

    Google Scholar 

  • Gambaro G, Vezzoli G, Casari G et al (2004) Genetics of hypercalciuria and calcium nephrolithiasis: from the rare monogenic to the common polygenic forms. Am J Kidney Dis 44(6):963–986

    Article  PubMed  CAS  Google Scholar 

  • Gückel C, Benz-Bohm G, Roth B (1989) Die Nephrokalzinose im Kindesalter. Sonographische Befunde und Differentialdiagnostik. Fortschr Röntgenstr 151:301–305

    Article  Google Scholar 

  • Ghazali S, Barratt TM (1974) Urinary excretion of calcium and magnesium in children. Arch Dis Child 49:97–101

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Habbig S, Beck BB, Hoppe B (2011) Nephrocalcinosis and urolithiasis in children. Kidney Int 80(12):1278–1291

    Article  PubMed  Google Scholar 

  • Hamm LL (1990) Renal handling of citrate. Kidney Int 38:728–735

    Article  PubMed  CAS  Google Scholar 

  • Hernanz-Schulman M (1991) Hyperechoic renal medullary pyramids in infants and children. Radiology 181:9–11

    Article  PubMed  CAS  Google Scholar 

  • Hess B, Nakagawa Y, Parks JH, Coe FL (1991) Molecular abnormality of Tamm-Horsfall glycoprotein in calcium oxalate nephrolithiasis. Am J Physiol 260(4 Part 2):F569–F578

    PubMed  CAS  Google Scholar 

  • Hess B, Metzger RM, Ackermann D, Montandon A, Jaeger P (1994) Infection-induced stone formation in a renal allograft. Am J Kidney Dis 24(5):868–872

    Article  PubMed  CAS  Google Scholar 

  • Hesse A, Classen A, Knoll M, Timmerman F, Vahlensieck W (1986) Dependance of urine composition on the age and sex of healthy subjects. Clin Chim Acta 160:79–86

    Article  PubMed  CAS  Google Scholar 

  • Hesse A, Vahlensieck W (1986) Loading tests for diagnosis of metabolic anomalies in urinary stone formers. Int J Urol Nephrol 18(1):45–53

    Article  CAS  Google Scholar 

  • Hicks NR, Cranston DW, Charlton CAC (1983) Fifteen year follow up of hyperoxaluria type II. N Engl J Med 309:796 (letter)

    PubMed  CAS  Google Scholar 

  • Hoppe B, Hesse A, Neuhaus T et al (1993a) Urinary saturation and nephrocalcinosis in preterm infants: effect of parenteral nutrition. Arch Dis Child 69:299–303

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hoppe B, Neuhaus T, Superti A, Leumann E (1993b) Hypercalciuria and nephrocalcinosis, a feature of Wilson’s disease. Nephron 65:460–462

    Article  PubMed  CAS  Google Scholar 

  • Hoppe B, Jahnen A, Bach D, Hesse A (1997) Urinary calcium-oxalate saturation in healthy infants and children. J Urol 158:557–559

    Article  PubMed  CAS  Google Scholar 

  • Hoppe B, Hesse A, Brömme S, Rietschel E, Michalk D (1998) Urinary excretion substances in patients with cystic fibrosis: risk of urolithiasis? Pediatr Nephrol 12:275–279

    Article  PubMed  CAS  Google Scholar 

  • Hoppe B, von Unruh GE, Blank G et al (2005) Absorptive hyperoxaluria leads to an increased risk of urolithiasis or nephrocalcinosis in cystic fibrosis. Am J Kidney Dis 46(3):440–445

    Article  PubMed  CAS  Google Scholar 

  • Hoppe B, Langman CB (2003) A United States survey on diagnosis, treatment, and outcome of primary hyperoxaluria. Pediatr Nephrol 18(10):986–991

    Article  PubMed  Google Scholar 

  • Hoppe B, Leumann A, Milliner DS (2008) Urolithiasis and nephrocalcinosis in childhood. In: Geary DF, Schaefer F (eds) Comprehensive pediatric nephrology. Elsevier, Philadelphia, pp 499–525

    Chapter  Google Scholar 

  • Hoppe B, Kemper M (2010) Diagnostic examination of the child with urolithiasis or nephrocalcinosis. Pediatr Nephrol 25(3):403–413

    Article  PubMed  Google Scholar 

  • Hoppe B (2012) An update an primary hyperoxaluria. Nat Rev Nephrol 8(8):467–75

    Article  PubMed  CAS  Google Scholar 

  • Horsford J, Saadi I, Raelson J, Goodyer PR, Rozen R (1996) Molecular genetics of cystinuria in French Canadians: identification of four novel mutations in type I patients. Kidney Int 49(5):1401–1406

    Article  PubMed  CAS  Google Scholar 

  • Hufnagle KG, Khan SN, Penn D, Cacciarelli A, Williams P (1982) Renal calcifications: a complication of long term furosemide therapy in preterm infants. Pediatrics 70:360–363

    PubMed  CAS  Google Scholar 

  • Hueppelshaeuser R, von Unruh GE, Habbig S et al (2012) Enteric hyperoxaluria, recurrent urolithiasis, and systemic oxalosis in patients with Crohn’s disease. Pediatr Nephrol 27(7):1103–1109

    Article  PubMed  Google Scholar 

  • Jacinto JS, Modanlou HD, Crade MC, Strauss AA, Bosu SK (1988) Renal calcification incidence in very low birth weight infants. Pediatrics 81:31–35

    PubMed  CAS  Google Scholar 

  • Jacob DE, Grohe B, Geßner M, Beck BB, Hoppe B (2013) Kidney stones in primary hyperoxaluria: new lessons learnt. PLoS One 8(8):e70617

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jacobus CH, Holick MF, Shao Q et al (1992) Hypervitaminosis D associated with drinking milk. N Engl J Med 326(18):1173–1177

    Article  PubMed  CAS  Google Scholar 

  • Jequier S, Kaplan BS (1991) Echogenic renal pyramids in children. J Clin Ultrasound 19:85–92

    Article  PubMed  CAS  Google Scholar 

  • Kalorin CM, Zabinski A, Okpareke I et al (2009) Pediatric urinary stone disease does age matter? J Urol 181(5):2267–2271

    Article  PubMed  Google Scholar 

  • Kamitsuka MD, Peloquin D (1991) Renal calcification after dexamethasone in infants with bronchopulmonary dysplasia. Lancet 337:626 (letter)

    Article  PubMed  CAS  Google Scholar 

  • Karlowicz MG, Adelman RD (1995) Renal calcification in the first year of life. Pediatr Clin North Am 42:1397–1413

    Article  PubMed  CAS  Google Scholar 

  • Katz ME, Karlowicz MG, Adelman RD, Werner AL, Solhaug MJ (1994) Nephrocalcinosis in very low birth weight neonates: sonographic patterns, histologic characteristics, and clinical risk factors. J Ultrasound Med 13:777–782

    Article  PubMed  CAS  Google Scholar 

  • Knoll T, Zöllner A, Wendt-Nordahl G et al (2005) Cystinuria in childhood and adolescence: recommendations for diagnosis, treatment, and follow-up. Pediatr Nephrol 20(1):19–24

    Article  PubMed  Google Scholar 

  • Kopp N, Leumann E (1995) Changing pattern of primary hyperoxaluria in Switzerland. Nephrol Dial Transplant 10:2224–2227

    Article  PubMed  CAS  Google Scholar 

  • Laufer J, Boichis H (1989) Urolithiasis in children: current medical management. Pediatr Nephrol 3:317–331

    Article  PubMed  CAS  Google Scholar 

  • Latta K, Brodehl J (1990) Primary hyperoxaluria type I. Eur J Pediatr 149:518–522

    Article  PubMed  CAS  Google Scholar 

  • Leumann EP, Niederwieser A, Fanconi A (1987) New aspects of infantile oxalosis. Pediatr Nephrol 1:531–535

    Article  PubMed  CAS  Google Scholar 

  • Leumann E, Hoppe B, Neuhaus T (1993) Management of primary hyperoxaluria: efficacy of oral citrate administration. Pediatr Nephrol 7:207–211

    Article  PubMed  CAS  Google Scholar 

  • Libenson MH, Kaye EM, Rosman NP, Gilmore HE (1999) Acetazolamide and furosemide for posthemorrhagic hydrocephalus of the newborn. Pediatr Neurol 20:185–191

    Article  PubMed  CAS  Google Scholar 

  • Lloyd SE, Pearce SH, Fisher SE et al (1996) A common molecular basis for three inherited kidney stone diseases. Nature 379(6564):398–399

    Article  Google Scholar 

  • Lopez M, Hoppe B (2010) History, epidemiology and regional diversities of urolithiasis. Pediatr Nephrol 25(1):49–59

    Article  PubMed  PubMed Central  Google Scholar 

  • Marangella M, Petrarulo M, Vitale C, Cosseddu D, Linari F (1992) Plasma and urine glycolate assays for differentiating the hyperoxaluria syndromes. J Urol 148:986–989

    Article  PubMed  CAS  Google Scholar 

  • Marangella M, Petrarulo M, Cosseddu D (1994) End-stage renal failure in primary hyperoxaluria type II. N Engl J Med 330:1690 (letter)

    Article  PubMed  CAS  Google Scholar 

  • Miller MA, Gallicano K, Dascal A, Mendelson J (1993) Sulfadiazine urolithiasis during antitoxoplasma therapy. Drug Invest 5:334–337

    Article  Google Scholar 

  • Miller LA, Stapleton FB (1985) Urinary citrate excretion in children with hypercalciuria. J Pediatr 107(2):263–266

    Article  PubMed  CAS  Google Scholar 

  • Milliner DS, Murphy ME (1993) Urolithiasis in pediatric patients. Mayo Clin Proc 68:313–315

    Article  Google Scholar 

  • Mindell HJ, Cochran ST (1994) Current perspectives in the diagnosis and treatment of urinary stone disease. AJR Am J Roentgenol 163:1314–1315

    Article  PubMed  CAS  Google Scholar 

  • Monico CG, Milliner DS (1999) Hyperoxaluria and urolithiasis in young children: an atypical presentation. J Endourol 13:633–636

    Article  PubMed  CAS  Google Scholar 

  • Monico CG, Rossetti S, Belostotsky R et al (2011) Primary hyperoxaluria type III gene HOGA1 (formerly DHDPSL) as a possible risk factor for idiopathic calcium oxalate urolithiasis. Clin J Am Soc Nephrol 6(9):2289–2295

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Myracle MR, McGahan JP, Goetzman BW, Adelman RD (1986) Ultrasound diagnosis of renal calcification in infants on chronic furosemide therapy. J Clin Ultrasound 14:281–287

    Article  PubMed  CAS  Google Scholar 

  • Novak TE, Lakshmanan Y, Trock BJ et al (2009) Sex prevalence of pediatric kidney stone disease in the United States: an epidemiologic investigation. Urology 74(1):104–107

    Article  PubMed  Google Scholar 

  • Navarro O, Daneman A, Kooh SW (1998) Asymmetric medullary nephrocalcinosis in two children. Pediatr Radiol 28:687–690

    Article  PubMed  CAS  Google Scholar 

  • Nayir A, Kadioglu A, Sirin A, Emre S, Tonguc E, Bilge I (1995) Causes of increased renal medullary echogenicity in Turkish children. Pediatr Nephrol 9:729–733

    Article  PubMed  CAS  Google Scholar 

  • Neuhaus T, Belzer T, Blau N, Hoppe B, Sidhu H, Leumann E (2000) Urinary oxalate excretion in urolithiasis and nephrocalcinosis. Arch Dis Child 82:322–326

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Oguzkurt L, Karabulut N, Haliloglu M, Ünal B (1997) Medullary nephrocalcinosis associated with vesicoureteral reflux. Br J Radiol 70:850–851

    Article  PubMed  CAS  Google Scholar 

  • Oner S, Oto A, Tekgul S et al (2004) Comparison of spiral CT and US in the evaluation of pediatric urolithiasis. JBR-BTR 87(5):219–223

    PubMed  CAS  Google Scholar 

  • Palmer JS, Donaher ER, O’Riordan MA et al (2005) Diagnosis of pediatric urolithiasis: role of ultrasound and computerized tomography. J Urol 174:1413–1416

    Article  PubMed  Google Scholar 

  • Patriquin H, Robitaille P (1986) Renal calcium deposition in children: sonographic demonstration of the Anderson-Carr progression. AJR Am J Roentgenol 146:1253–1256

    Article  PubMed  CAS  Google Scholar 

  • Pfitzer A, Nelle M, Rohrschneider W, Linderkamp O, Tröger J (1998) Inzidenz nephrokalzinosetypischer Sonographiebefunde bei Frühgeborenen während enteraler Kalzium- und Phosphatgabe. Z Geburtsh Neonatol 202:159–163

    CAS  Google Scholar 

  • Pietrow PK, Pope JC, Adams MC et al (2002) Clinical outcome of pediatric stone disease. J Urol 167:670–673

    Article  PubMed  Google Scholar 

  • Pope JC, Trusler LA, Klein AM, Walsh WF, Yared A, Brock JW (1996) The natural history of nephrocalcinosis in premature infants treated with loop diuretics. J Urol 156:709–712

    Article  PubMed  Google Scholar 

  • Preminger GM, Sakhaee K, Skurla C, Pak CYC (1985) Prevention of recurrent calcium stone formation with potassium citrate therapy in patients with distal renal tubular acidosis. J Urol 134:20–24

    Article  PubMed  CAS  Google Scholar 

  • Purdue PE, Lumb MJ, Fox M et al (1991) Characterisation and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase. Genomics 10:34–42

    Article  PubMed  CAS  Google Scholar 

  • Ragavan VV, Smith JE, Bilezikian JP (1982) Vitamin A toxicity and hypercalcemia. Am J Med Sci 283(3):161–164

    Article  PubMed  CAS  Google Scholar 

  • Raj GV, Bennett RT, Preminger GM, King LR, Wiener JS (1999) The incidence of nephrolithiasis in patients with spinal neural tube defects. J Urol 162:1238–1242

    Article  PubMed  CAS  Google Scholar 

  • Randall A (1937) The origin and growth of renal calculi. Ann Surg 105(6):1009–1027

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rausch HP, Hanefeld F, Kaufmann HJ (1984) Medullary nephrocalcinosis and pancreatic calcifications demonstrated by ultrasound and CT in infants after treatment with ACTH. Radiology 153:105–107

    Article  PubMed  CAS  Google Scholar 

  • Restaino I, Kaplan BS, Stanley C, Baker L (1993) Nephrolithiasis, hypocitraturia, and a distal renal tubular acidification defect in type I glycogen storage disease. J Pediatr 122(3):392–396

    Article  PubMed  CAS  Google Scholar 

  • Riedel TJ, Knight J, Murray MS, Milliner DS, Holmes RP, Lowther WT (2012) 4-hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition. Biochim Biophys Acta 1822(10):1544–1552

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rönnefarth G, Misselwitz J (2000) Nephrocalcinosis in children: a retrospective survey. Members of the Arbeitsgemeinschaft für pädiatrische Nephrologie. Pediatr Nephrol 14(10-11):1016–1021

    Article  PubMed  Google Scholar 

  • Ryall RL (1996) Glycosaminoglycans, proteins, and stone formation: adult themes and child’s play. Pediatr Nephrol 10(5):656–666

    Article  PubMed  CAS  Google Scholar 

  • Sas DJ, Hulsey TC, Shatat IF et al (2010) Increasing incidence of kidney stones in children evaluated in the emergency department. J Pediatr 157(1):132–137

    Article  PubMed  Google Scholar 

  • Schell-Feith EA, van Holthe KJE, Conneman N et al (2000) Etiology of nephrocalcinosis in preterm neonates: association of nutritional intake and urinary parameters. Kidney Int 58:2102–2110

    Article  PubMed  CAS  Google Scholar 

  • Shultz PK, Strife JL, Strife CF, McDaniel JD (1991) Hyperechoic renal medullary pyramids in infants and children. Radiology 181:163–167

    Article  PubMed  CAS  Google Scholar 

  • Schlingmann KP, Kaufmann M, Weber S et al (2011) Mutations in CYP24A1 and idiopathic infantile hypercalcemia. N Engl J Med 365(5):410–421

    Article  PubMed  CAS  Google Scholar 

  • Sidhu H, Hoppe B, Hesse A et al (1998) Absence of Oxalobacter formigenes in cystic fibrosis patients: a risk factor for hyperoxaluria. Lancet 352:1026–1029

    Article  PubMed  CAS  Google Scholar 

  • Sikora P, Roth B, Kribs A et al (2003) Hypocitraturia is one of the major risk factors for nephrocalcinosis in very low birth weight (VLBW) infants. Kidney Int 63:2194–2199

    Article  PubMed  CAS  Google Scholar 

  • Sliman GA, Winters WD, Shaw DW, Avner ED (1995) Hypercalciuria and nephrocalcinosis in the oculocerebrorenal syndrome. J Urol 153(4):1244–1246

    Article  PubMed  CAS  Google Scholar 

  • Smith RC, Rosenfield AT, Choe KA et al (1995) Acute flank pain: comparison of non-contrast-enhanced CT and intravenous urography. Radiology 194:789–794

    Article  PubMed  CAS  Google Scholar 

  • Sonntag J, Schaub J (1997) Oxalate excretion during the first 7 weeks in very-low-birth-weight infants. Biol Neonate 71:277–281

    Article  PubMed  CAS  Google Scholar 

  • Spivacow FR, Negri AL, del Valle EE et al (2010) Clinical and metabolic risk factor evaluation in young adults with kidney stones. Int Urol Nephrol 42(2):471–475

    Article  PubMed  Google Scholar 

  • Stapleton FB (1983) Idiopathic hypercalciuria in children. Semin Nephrol 3(2):116–124

    Google Scholar 

  • Stapleton FB (1996a) Clinical approach to children with urolithiasis. Semin Nephrol 3:116–124

    Google Scholar 

  • Stapleton FB (1996b) Clinical approach to children with urolithiasis. Semin Nephrol 16(5):389–397

    PubMed  CAS  Google Scholar 

  • Starinsky R, Vardi O, Batasch D, Goldberg M (1995) Increased renal medullary echogenicity in neonates. Pediatr Radiol 25:43–45

    Google Scholar 

  • Strouse PJ, Bates DG, Bloom DA, Goodsitt MM (2002) Non-contrast thin-section helical CT of urinary tract calculi in children. Pediatr Radiol 32(5):326–332

    Article  PubMed  Google Scholar 

  • Taylor A, Sherman NH, Norman ME (1995) Nephrocalcinosis in X-linked hypophosphatemia: effect of treatment versus disease. Pediatr Nephrol 9:173–175

    Article  PubMed  CAS  Google Scholar 

  • Williams HE, Wandzilak TE (1989) Oxalate synthesis, transport and the hyperoxaluric syndromes. J Urol 141:742–747

    Article  PubMed  CAS  Google Scholar 

  • VanDervoort K, Wiesen J, Frank R et al (2007) Urolithiasis in pediatric patients: a single center study of incidence, clinical presentation and outcome. J Urol 177(6):2300–2305

    Article  PubMed  Google Scholar 

  • Verkoelen CF, van der Boom BG, Houtsmuller AB et al (1998) Increased calcium oxalate monohydrate crystal binding to injured renal tubular epithelial cells in culture. Am J Physiol 274:F958–F965

    Article  PubMed  CAS  Google Scholar 

  • Vervaet BA, Verhulst A, D’Haese PC et al (2009) Nephrocalcinosis: new insights into mechanisms and consequences. Nephrol Dial Transplant 24(7):2030–2035

    Article  PubMed  CAS  Google Scholar 

  • Vezzoli G, Terranegra A, Arcidiacono T et al (2010) Calcium kidney stones are associated with a haplotype of the calcium-sensing receptor gene regulatory region. Nephrol Dial Transplant 25(7):2245–2252

    Article  PubMed  CAS  Google Scholar 

  • Walther PC, Lamm D, Kaplan GW (1980) Pediatric urolithiases: a ten-year review. Pediatrics 65(6):1068–1072

    PubMed  CAS  Google Scholar 

  • Zanchetta JR, Rodriguez G, Negir AL, del Valle E, Spivacow FR (1996) Bone mineral density in patients with hypercalciuric nephrolithiasis. Nephron 73:557–560

    Article  PubMed  CAS  Google Scholar 

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Hoppe, B. (2018). Urolithiasis and Nephrocalcinosis. In: Riccabona, M. (eds) Pediatric Urogenital Radiology. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/978-3-319-39202-8_16

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