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Two-Dimensional Peptide and Protein Assemblies

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Protein-based Engineered Nanostructures

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 940))

Abstract

Two-dimensional nanoscale assemblies (nanosheets) represent a promising structural platform to arrange molecular and supramolecular substrates with precision for integration into devices. This nanoarchitectonic approach has gained significant traction over the last decade, as a general concept to guide the fabrication of functional nanoscale devices. Sequence-specific biomolecules, e.g., peptides and proteins, may be considered excellent substrates for the fabrication of two-dimensional nanoarchitectonics. Molecular level instructions can be encoded within the sequence of monomers, which allows for control over supramolecular structure if suitable design principles could be elaborated. Due to the complexity of interactions between protomers, the development of principles aimed toward rational design of peptide and protein nanosheets is at a nascent stage. This review discusses the known two-dimensional peptide and protein assemblies to further our understanding of how to control the arrangement of molecules in two-dimensions.

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Acknowledgment

E.M. and V.P.C. thank the National Science Foundation grant CHE-1412580 for financial support. In addition, we acknowledge the generosity of many of the investigators cited in this review for providing original artwork for creation of the figures in the manuscript.

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  1. Department of Chemistry, Emory University, 1515 Dickey Drive, 30322, Atlanta, GA, USA

    Elizabeth Magnotti & Vincent Conticello

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  1. Elizabeth Magnotti
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  2. Vincent Conticello
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Correspondence to Vincent Conticello .

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  1. CIC BiomaGUNE, Donostia-San Sebastián, Spain

    Aitziber L. Cortajarena

  2. Department of Chemistry, Virginia Tech, Blacksburg, Virginia, USA

    Tijana Z. Grove

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Magnotti, E., Conticello, V. (2016). Two-Dimensional Peptide and Protein Assemblies. In: Cortajarena, A., Grove, T. (eds) Protein-based Engineered Nanostructures. Advances in Experimental Medicine and Biology, vol 940. Springer, Cham. https://doi.org/10.1007/978-3-319-39196-0_3

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