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Design of Redox-Active Peptides: Towards Functional Materials

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Protein-based Engineered Nanostructures

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 940))

Abstract

In nature, the majority of processes that occur in the cell involve the cycling of electrons and protons, changing the reduction and oxidation state of substrates to alter their chemical reactivity and usefulness in vivo. One of the most relevant examples of these processes is the electron transport chain, a series of oxidoreductase proteins that shuttle electrons through well-defined pathways, concurrently moving protons across the cell membrane. Inspired by these processes, researchers have sought to develop materials to mimic natural systems for a number of applications, including fuel production. The most common cofactors found in proteins to carry out electron transfer are iron sulfur clusters and porphyrin-like molecules. Both types have been studied within natural proteins, such as in photosynthetic machinery or soluble electron carriers; in parallel, an extensive literature has developed over recent years attempting to model and study these cofactors within peptide-based materials. This chapter will focus on major designs that have significantly advanced the field.

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Authors and Affiliations

  1. School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287-1604, USA

    Dayn Joseph Sommer, Rafael Alcala-Torano, Zahra Bahrami Dizicheh & Giovanna Ghirlanda

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  1. Dayn Joseph Sommer
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  2. Rafael Alcala-Torano
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  3. Zahra Bahrami Dizicheh
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  4. Giovanna Ghirlanda
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Correspondence to Giovanna Ghirlanda .

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Editors and Affiliations

  1. CIC BiomaGUNE, Donostia-San Sebastián, Spain

    Aitziber L. Cortajarena

  2. Department of Chemistry, Virginia Tech, Blacksburg, Virginia, USA

    Tijana Z. Grove

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Sommer, D.J., Alcala-Torano, R., Dizicheh, Z.B., Ghirlanda, G. (2016). Design of Redox-Active Peptides: Towards Functional Materials. In: Cortajarena, A., Grove, T. (eds) Protein-based Engineered Nanostructures. Advances in Experimental Medicine and Biology, vol 940. Springer, Cham. https://doi.org/10.1007/978-3-319-39196-0_10

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