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Lipid-Based Nanoparticles in Cosmetic and Pharmaceutical Products for the Skin

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Bionanomaterials for Skin Regeneration

Part of the book series: SpringerBriefs in Bioengineering ((BRIEFSBIOENG))

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Abstract

Topical delivery of drugs to the skin, for skin or for musculoskeletal conditions, is valued because it allows use of smaller loads of active ingredients to obtain the same effect as that obtained following oral or parenteral administration. This results in reduction of systemic side effects and avoidance of passage through the liver after intestinal absorption. The problems for this type of treatment are the possibility to control it, to evaluate the exact amount of active agent to reach each skin layer/target site, and most of all, to overcome the barrier represented by the (SC). This barrier, more efficient against hydrophilic species, allows absorption which ranges between 1 % of a dose of active (hydrocortisone) on the soles and 42 % when applied to the eyelids [1]. Moreover, in some skin diseases, due to a partially disturbed skin structure, the uptake of the topically applied medication may be high enough to produce unwanted local (rashes) or systemic side effects, while in other situations the uptake of compounds delivered as creams or gels may be lower than the effective level.

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Notes

  1. 1.

    Other sources consider 500 Da as the limit

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  1. Fairleigh Dickinson University, Teaneck, NJ, USA

    Mihaela D. Leonida & Ish Kumar

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  1. Mihaela D. Leonida
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  2. Ish Kumar
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Leonida, M.D., Kumar, I. (2016). Lipid-Based Nanoparticles in Cosmetic and Pharmaceutical Products for the Skin. In: Bionanomaterials for Skin Regeneration. SpringerBriefs in Bioengineering. Springer, Cham. https://doi.org/10.1007/978-3-319-39168-7_7

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  • DOI: https://doi.org/10.1007/978-3-319-39168-7_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-39166-3

  • Online ISBN: 978-3-319-39168-7

  • eBook Packages: EngineeringEngineering (R0)

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