Abstract
Cellulose is a biopolymer (β-(1-4)-D-glucopyranose), the main structural element in plants and bacterial wall. It is the most abundant natural polymer on Earth, its production estimated at 7.5 × 1010 metric tons annually. It is insoluble in water and contains both crystalline and amorphous regions. Its amphiphilic character, arising from the presence and arrangement of the numerous −OH groups (H-bonds, hydrophobic interactions, dispersion forces), determines the properties and behavior of cellulose in aqueous environment [1]. Most cellulose available consists of wood fibers and components of cell walls. Nanocelluloses, composed of nanoscaled structures based on cellulose, are more and more given attention as novel promising nanomaterials. Their physical properties, high surface area, and biological properties (biocompatibility, low toxicity, biodegradability) made them important for biomedical applications in treating skin diseases and in skin care. Very few organisms can synthesize directly nanosized cellulose fibers. Some of those are blue-green algae and bacteria such as Acetobacter xylinum.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Medronho B, Romano A, Miguel MG, Stigsson L, Lindman B (2012) Rationalizing cellulose (in)solubility: reviewing basic physico-chemical aspects and role of hydrophobic interactions. Cellulose 19:581–587
Peng BL, Dhar N, Liu HL, Tam KC (2011) Chemistry and applications of nanocrystalline cellulose and its derivatives: a nanotechnology perspective. Can J Chem Eng 89(5):1191–1206
Eichorn SJ (2011) Cellulose nanowhiskers: promising materials for advanced applications. Soft Matter 7(2):303–315
Lin N, Dufresne A (2014) Nanocellulose in biomedicine: current status and future. Eur Polym J 59:302–325
American Chemical Society (2013) Engineering algae to make the “wonder material” nanocellulose for biofuels and more. http://www.eurekalert.org/pub_releases/2013-04/acs-eat031813.php. Accessed 1 Dec 2015
Aulin C, Ahola S, Josefsson P, Nishino T, Hirose Y, Österberg M, Wågberg L (2009) Nanoscale cellulose films with different crystallinities and mesostructures-their surface properties and interaction with water. Langmuir 25(13):7675–7685
Menchaca-Nal S, Londono-Calderon C, Cerrutti P, Foresti ML, Pampillo L, Bilovol V, Candal R, Martinez-Garcia R (2015) Facile synthesis of cobalt ferrite nanotubes using bacterial nanocellulose as template. Carbohydr Polym. doi:10.1016/j.carbpol.2015.10.068. Accessed 1 Dec 2015
Lee K-Y, Buldum G, Mantalaris A, Bismark A (2014) More than meets the eye in bacterial cellulose: biosynthesis, bioprocessing, and applications in advanced fiber composites. Macromol Biosci 14:10–32
Thielemans W, Warbey CA, Walsh DA (2009) Permselective nanostructured membranes based on cellulose nanowhiskers. Green Chem 11(4):531–537
Labet M, Thielemans W (2011) Improving the reproducibility of chemical reactions on the surface of cellulose nanocrystals: ROP of e-caprolactone as a case study. Cellulose 18(3):607–617
Lin N, Dufresne A (2014) Surface chemistry, morphological analysis and properties of cellulose nanocrystals with gradiented sulfation degrees. Nanoscale 6:5384–5393
Fu L, Zhang J, Yang G (2013) Present status and applications of bacterial cellulose-based materials for skin tissue repair. Carbohydr Polym 92:1432–1442
Helenius G, Bäckdahl H, Bodin A, Nannmark U, Gatenholm P, Risberg B (2006) In vivo biocompatibility of bacterial cellulose. J Biomed Mater Res A 76:431–438
Andrade FK, Silva JP, Carvalho M, Castanheira EMS, Soares R (2011) Gama studies on the hemocompatibility of bacterial cellulose. J Biomed Mater Res A 98:554–566
Ferraz N, Carlsson DO, Hong J, Larsson R, Fellström B, Nyholm L (2012) Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification. J R Soc Interface 9:1943–1955
Leitao AF, Gupta S, Silva JP, Reviakine I, Gama M (2013) Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite. Colloids Surf B Biointerfaces 111:493–502
Kümmerer K, Menz J, Schubert T, Thielemans W (2011) Biodegradability of organic nanoparticles in the aqueous environment. Chemosphere 82:1387–1392
Li J, Wan YZ, Li LF, Liang H, Wang JH (2009) Preparation and characterization of 2,3-dialdehyde bacterial cellulose for potential biodegradable tissue engineering scaffolds. Mater Sci Eng C 29:1635–1642
Jorfi M, Foster EJ (2015) Recent advances in nanocellulose for biomedical applications. J Appl Polym Sci. http://onlinelibrary.wiley.com/doi/10.1002/app.41719. Accessed 28 Jan 2016
Portal O, Clark WA, Levinson DJ (2009) Microbial cellulose wound dressing in the treatment of nonhealing lower extremity ulcers. Wounds 21:1–3
Czaja W, Krystynowicz A, Kawecki M, Wysota K, Sakiel S, Wróblewski P (2007) Biomedical applications of microbial cellulose in burn wound recovery. In: Brow RM Jr, Saxena IM (eds) Cellulose: molecular and structural biology. Springer, New York/Heidelberg/Dordrecht/London, pp 307–321
Brown Jr RM, Czaja W, Jeschke M, Young DJ (2006) Multiribbon nanocellulose as a matrix for wound healing. US Patent 0053960 A1, filed 31 Aug 2006, issued 8 Mar 2007
Cai ZJ, Yang G (2011) Bacterial cellulose/collagen composite: characterization and first evaluation of cytocompatibility. J Appl Polym Sci 120:2938–2944
Cai Z, Kim J (2010) Bacterial cellulose/poly(ethylene glycol) composite: characterization and first evaluation of biocompatibility. Cellulose 17:83–91
Gonzalez JS, Ludueña LN, Ponce A, Alvarez VA (2014) Poly(vinyl alcohol)/cellulose nanowhiskers nanocomposite hydrogels for potential wound dressings. Mater Sci Eng C 34:54–61
Lin WC, Lien CC, Yeh HJ, Yu CM, Hsu SH (2013) Bacterial cellulose and bacterial cellulose-chitosan membranes for wound dressing applications. Carbohydr Polym 94:603–611
Nakayama A, Kakugo A, Gong JP, Osada Y, Takai M, Erata T (2004) High mechanical strength double-network hydrogel with bacterial cellulose. Adv Funct Mater 14:1124–1128
Lin N, Bruzzese C, Dufresne A (2012) TEMPO-oxidized nanocellulose participating as crosslinking aid for alginate-based sponges. ACS Appl Mater Interfaces 4:4948–4959
Svagan AJ, Azizi Samir MAS, Berglund LA (2008) Biomimetic foams of high mechanical performance based on nanostructured cell walls reinforced by native nanofibrils. Adv Mater 20(7):1263–1269
Heath L, Thielemans W (2010) Cellulose nanowhisker aerogels. Green Chem 12(8):1448–1453
Pääkkö M, Vapaavuori J, Silvennoinen R, Kosonen H, Ankerfors M, Lindström T, Berglund LA, Ikkala O (2008) Long and entangled native cellulose I nanofibers allow flexible aerogels and hierarchically templates for functionalities. Soft Matter 4(12):2492–2499
Moritz S, Wiegand C, Wesarg F, Hessler N, Műller FA, Kralisch D, Hipler U-C, Fischer D (2014) Active wound dressings based on bacterial nanocellulose as drug delivery system for octenidine. Int J Pharm 471:45–55
Rai M, Yadav A, Gade A (2009) Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv 27:76–83
Xiong R, Lu C, Zhang W, Zhou Z, Zhang X (2013) Facile synthesis of tunable silver nanostructures for antibacterial application using cellulose nanocrystals. Carbohydr Polym 95:214–219
Auras R, Lim L-T, Selke SEM, Tsuji H (eds) (2010) Poly(lactic acid): synthesis, structures, properties, processing, and applications. http://onlinelibrary.wiley. doi:10.1002/9780470649848
Yu H-Y, Qin Z-Y, Sun B, Yan CF, Yao J-M (2014) One-pot green fabrication and antibacterial activity of thermally stable corn-like CNC/Ag nanocomposites. J Nanopart Res 16:2202–2213
Liu H, Song J, Shang S, Song Z, Wang D (2012) Cellulose nanocrystal/silver nanoparticle composites as bifunctional nanofillers within waterborne polyurethane. ACS Appl Mater Interfaces 4:2413–2419
Martins NCT, Freire CSR, Pinto RJB, Fernandes SCM, Neto CP, Silvestre AJD (2012) Electrostatic assembly of Ag nanoparticles onto nanofibrillated cellulose for antibacterial paper products. Cellulose 19:1425–1436
Díez I, Eronen P, Österberg M, Linder MB, Ikkala O, Ras RHA (2011) Functionalization of nanofibrillated cellulose with silver nanoclusters: fluorescence and antibacterial activity. Macromol Biosci 11:1185–1191
Berndt S, Wesarg F, Wiegand C, Kralisch D, Müller FA (2013) Antimicrobial porous hybrids consisting of bacterial nanocellulose and silver nanoparticles. Cellulose 20:771–783
Olszewska K (2013) Hydrogel adhesive bandage for chronic wounds. http://www.nauka.gov.pl/en/polish-science-news/hydrogel-adhesive-bandage-for-chronic-wounds.html. Accessed 16 Oct 2015
Azizi S, Ahmad M, Mahdavi M, Abdolmohammadi S (2013) Preparation, characterization, and antimicrobial activities of ZnO nanoparticles/cellulose nanocrystal nanocomposites. BioResources 8:1841–1851
Martins NCT, Freire CSR, Neto CP, Silvestre AJD, Causio J, Baldi G, Sadocco P, Trindade T (2013) Antibacterial paper based on composite coatings of nanofibrillated cellulose and ZnO. Colloids Surf A Physicochem Eng Asp 417:111–119
Ul-Islam M, Khattak WA, Ullah MW, Khan S, Park JK (2014) Synthesis of regenerated bacterial cellulose–zinc oxide nanocomposite films for biomedical applications. Cellulose 21:433–447
Andresen M, Stenstad P, Møretrø T, Langsrud S, Syverud K, Johansson L-S, Stenius P (2007) Nonleaching antimicrobial films prepared from surface-modified microfibrillated cellulose. Biomacromolecules 8:2149–2155
Wei B, Yang G, Hong F (2011) Preparation and evaluation of a kind of bacterial cellulose dry films with antibacterial properties. Carbohydr Polym 84:533–538
Liu K, Lin X, Chen L, Huang L, Cao S, Wang H (2013) Preparation of microfibrillated cellulose/chitosan–benzalkonium chloride biocomposite for enhancing antibacterium and strength of sodium alginate films. J Agric Food Chem 61:6562–6567
Liu K, Lin X, Chen L, Huang L, Cao S (2014) Dual-functional chitosan– methylisothiazolinone/microfibrillated cellulose biocomposites for enhancing antibacterial and mechanical properties of agar films. Cellulose 21:519–528
Gao C, Yan T, Du J, He F, Luo H, Wan Y (2014) Introduction of broad spectrum antibacterial properties to bacterial cellulose nanofibers via immobilizing ε-polylysine nanocoatings. Food Hydrocolloids 36:204–211
Jipa IM, Stoica-Guzun A, Stroescu M (2012) Controlled release of sorbic acid from bacterial cellulose based mono and multilayer antimicrobial films. Food Sci Technol 47:400–406
Rouabhia M, Asselin J, Tazi N, Messaddeq Y, Levinson D, Zhang Z (2014) Production of biocompatible and antimicrobial bacterial cellulose polymers functionalized by RGDC grafting groups and gentamicin. ACS Appl Mater Interfaces 6:1439–1446
Carpenter BL, Feese E, Sadeghifar H, Argyropoulos DS, Ghiladi RA (2012) Porphyrin-cellulose nanocrystals: a photobactericidal material that exhibits broad spectrum antimicrobial activity. J Photochem Photobiol 88:527–536
Chinga-Carrasco G, Syverud K (2014) Pretreatment-dependent surface chemistry of wood nanocellulose for pH-sensitive hydrogels. J Biomater Appl 29(3):423–432
Roemhild K, Wiegand C, Hipler U-C, Heinze T (2013) Novel bioactive amino-functionalized cellulose nanofibers. Macromol Rapid Commun 34:1767–1771
Fernandes SCM, Sadocco P, Alonso-Varona A, Palomares T, Eceiza A, Silvestre AJD, Mondragon I, Freire CS (2013) Bioinspired antimicrobial and biocompatible bacterial cellulose membranes obtained by surface functionalization with aminoalkyl groups. ACS Appl Mater Interfaces 5:3290–3297
Butchosa N, Brown C, Larsson PT, Berglund LA, Bulone V, Zhou Q (2013) Nanocomposites of bacterial cellulose nanofibers and chitin nanocrystals: fabrication, characterization and bactericidal activity. Green Chem 15:3404–3413
Ul-Islam M, Khan T, Khattak WA, Park JK (2013) Bacterial cellulose-MMTs nanoreinforced composite films: novel wound dressing material with antibacterial properties. Cellulose 20:589–596
Li H, Peng L (2015) Antibacterial and antioxidant surface modification of cellulose fibers using layer-by-layer deposition of chitosan and lignosulfonates. Carbohydr Polym 124:35–42
Xhanari K, Syverud K, Stenius P (2011) Emulsions stabilized by microfibrillated cellulose: the effect of hydrophobization, concentration and o/w ratio. J Dispers Sci Technol 32(3):447–452
Aramwit P, Bang N (2014) The characteristics of bacterial nanocellulose releasing silk sericin for facial treatment. BMC Biotechnol 14:104–115
Aramwit P, Kanokpanont S, Nakpheng T, Srichana T (2010) The effect of sericin from various extraction methods on cell viability and collagen production. Int J Mol Sci 11:2200–2211
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Leonida, M.D., Kumar, I. (2016). Nanocellulose. In: Bionanomaterials for Skin Regeneration. SpringerBriefs in Bioengineering. Springer, Cham. https://doi.org/10.1007/978-3-319-39168-7_10
Download citation
DOI: https://doi.org/10.1007/978-3-319-39168-7_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-39166-3
Online ISBN: 978-3-319-39168-7
eBook Packages: EngineeringEngineering (R0)