Abstract
A substantial proportion of the dazzling diversity of colors displayed by living organisms throughout the tree of life is determined by the presence of carotenoids, which most often provide distinctive yellow, orange and red hues. These metabolites play fundamental roles in nature that extend far beyond their importance as pigments. In photosynthetic lineages, carotenoids are essential to sustain life, since they have been exploited to maximize light harvesting and protect the photosynthetic machinery from photooxidative stress. Consequently, photosynthetic organisms have evolved several mechanisms that adjust the carotenoid metabolism to efficiently cope with constantly fluctuating light environments. This chapter will focus on the current knowledge concerning the regulation of the carotenoid biosynthetic pathway in leaves, which are the primary photosynthetic organs of most land plants.
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References
Aharoni A, Giri AP, Deuerlein S, Griepink F, de Kogel WJ, Verstappen FW, Verhoeven HA, Jongsma MA, Schwab W, Bouwmeester HJ (2003) Terpenoid metabolism in wild-type and transgenic Arabidopsis plants. Plant Cell 15(12):2866–2884
Al-Babili S, von Lintig J, Haubruck H, Beyer P (1996) A novel, soluble form of phytoene desaturase from Narcissus pseudonarcissus chromoplasts is Hsp70-complexed and competent for flavinylation, membrane association and enzymatic activation. Plant J 9(5):601–612
Albrecht M, Sandmann G (1994) Light-stimulated carotenoid biosynthesis during transformation of maize etioplasts is regulated by increased activity of isopentenyl pyrophosphate isomerase. Plant Physiol 105(2):529–534
Altincicek B, Kovacs JL, Gerardo NM (2012) Horizontally transferred fungal carotenoid genes in the two-spotted spider mite Tetranychus urticae. Biol Lett 8(2):253–257
Armstrong GA (1994) Eubacteria show their true colors: genetics of carotenoid pigment biosynthesis from microbes to plants. J Bacteriol 176(16):4795–4802
Armstrong GA (1997) Genetics of eubacterial carotenoid biosynthesis: a colorful tale. Annu Rev Microbiol 51:629–659
Bae G, Choi G (2008) Decoding of light signals by plant phytochromes and their interacting proteins. Annu Rev Plant Biol 59:281–311
Balmer Y, Koller A, del Val G, Manieri W, Schurmann P, Buchanan BB (2003) Proteomics gives insight into the regulatory function of chloroplast thioredoxins. Proc Natl Acad Sci U S A 100(1):370–375
Baroli I, Niyogi KK (2000) Molecular genetics of xanthophyll-dependent photoprotection in green algae and plants. Philos Trans R Soc Lond B Biol Sci 355(1402):1385–1394
Barta C, Loreto F (2006) The relationship between the methyl-erythritol phosphate pathway leading to emission of volatile isoprenoids and abscisic acid content in leaves. Plant Physiol 141(4):1676–1683
Bartley GE, Scolnik PA (1995) Plant carotenoids: pigments for photoprotection, visual attraction, and human health. Plant Cell 7(7):1027–1038
Bauer C, Elsen S, Swem LR, Swem DL, Masuda S (2003) Redox and light regulation of gene expression in photosynthetic prokaryotes. Philos Trans R Soc Lond B Biol Sci 358(1429):147–153
Beisel KG, Jahnke S, Hofmann D, Koppchen S, Schurr U, Matsubara S (2010) Continuous turnover of carotenes and chlorophyll a in mature leaves of Arabidopsis revealed by 14CO2 pulse-chase labeling. Plant Physiol 152(4):2188–2199
Blankenship RE (2010) Early evolution of photosynthesis. Plant Physiol 154(2):434–438
Bohne F, Linden H (2002) Regulation of carotenoid biosynthesis genes in response to light in Chlamydomonas reinhardtii. Biochim Biophys Acta 1579(1):26–34
Bollag W (1996) The retinoid revolution. Overv FASEB J 10(9):938–939
Bonk M, Hoffmann B, Von Lintig J, Schledz M, Al-Babili S, Hobeika E, Kleinig H, Beyer P (1997) Chloroplast import of four carotenoid biosynthetic enzymes in vitro reveals differential fates prior to membrane binding and oligomeric assembly. Eur J Biochem 247(3):942–950
Botella-Pavia P, Besumbes O, Phillips MA, Carretero-Paulet L, Boronat A, Rodriguez-Concepcion M (2004) Regulation of carotenoid biosynthesis in plants: evidence for a key role of hydroxymethylbutenyl diphosphate reductase in controlling the supply of plastidial isoprenoid precursors. Plant J 40(2):188–199
Bouvier F, Rahier A, Camara B (2005) Biogenesis, molecular regulation and function of plant isoprenoids. Prog Lipid Res 44(6):357–429
Breitenbach J, Sandmann G (2005) zeta-Carotene cis isomers as products and substrates in the plant poly-cis carotenoid biosynthetic pathway to lycopene. Planta 220(5):785–793
Briggs WR, Olney MA (2001) Photoreceptors in plant photomorphogenesis to date. Five phytochromes, two cryptochromes, one phototropin, and one superchrome. Plant Physiol 125(1):85–88
Buchanan BB, Schurmann P, Wolosiuk RA, Jacquot JP (2002) The ferredoxin/thioredoxin system: from discovery to molecular structures and beyond. Photosynth Res 73(1–3):215–222
Bugos RC, Chang SH, Yamamoto HY (1999) Developmental expression of violaxanthin de-epoxidase in leaves of tobacco growing under high and low light. Plant Physiol 121(1):207–214
Bugos RC, Yamamoto HY (1996) Molecular cloning of violaxanthin de-epoxidase from romaine lettuce and expression in Escherichia coli. Proc Natl Acad Sci U S A 93(13):6320–6325
Busch M, Seuter A, Hain R (2002) Functional analysis of the early steps of carotenoid biosynthesis in tobacco. Plant Physiol 128(2):439–453
Camara B, Bardat F, Moneger R (1982) Sites of biosynthesis of carotenoids in Capsicum chromoplasts. Eur J Biochem 127(2):255–258
Candau R, Bejarano ER, Cerda-Olmedo E (1991) In vivo channeling of substrates in an enzyme aggregate for beta-carotene biosynthesis. Proc Natl Acad Sci U S A 88(11):4936–4940
Carail M, Caris-Veyrat C (2006) Carotenoid oxidation products: From villain to saviour? Pure Appl Chem 78(8):1493–1503
Carol P, Kuntz M (2001) A plastid terminal oxidase comes to light: implications for carotenoid biosynthesis and chlororespiration. Trends Plant Sci 6(1):31–36
Carretero-Paulet L, Ahumada I, Cunillera N, Rodriguez-Concepcion M, Ferrer A, Boronat A, Campos N (2002) Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. Plant Physiol 129(4):1581–1591
Carretero-Paulet L, Cairo A, Botella-Pavia P, Besumbes O, Campos N, Boronat A, Rodriguez-Concepcion M (2006) Enhanced flux through the methylerythritol 4-phosphate pathway in Arabidopsis plants overexpressing deoxyxylulose 5-phosphate reductoisomerase. Plant Mol Biol 62(4–5):683–695
Castillon A, Shen H, Huq E (2007) Phytochrome Interacting Factors: central players in phytochrome-mediated light signaling networks. Trends Plant Sci 12(11):514–521
Cazzaniga S, Li Z, Niyogi KK, Bassi R, Dall’Osto L (2012) The Arabidopsis szl1 mutant reveals a critical role of beta-carotene in photosystem I photoprotection. Plant Physiol 159(4):1745–1758
Cazzonelli CI (2011) Carotenoids in nature: insights from plants and beyond. Func Plant Biol 38:833–847
Cazzonelli CI, Cuttriss AJ, Cossetto SB, Pye W, Crisp P, Whelan J, Finnegan EJ, Turnbull C, Pogson BJ (2009) Regulation of carotenoid composition and shoot branching in Arabidopsis by a chromatin modifying histone methyltransferase, SDG8. Plant Cell 21(1):39–53
Cazzonelli CI, Pogson BJ (2010) Source to sink: regulation of carotenoid biosynthesis in plants. Trends Plant Sci 15(5):266–274
Cazzonelli CI, Roberts AC, Carmody ME, Pogson BJ (2010) Transcriptional control of SET DOMAIN GROUP 8 and CAROTENOID ISOMERASE during Arabidopsis development. Mol Plant 3(1):174–191
Cobbs C, Heath J, Stireman JO 3rd, Abbot P (2013) Carotenoids in unexpected places: gall midges, lateral gene transfer, and carotenoid biosynthesis in animals. Mol Phylogenet Evol 68(2):221–228
Cordoba E, Salmi M, Leon P (2009) Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants. J Exp Bot 60(10):2933–2943
Covington MF, Maloof JN, Straume M, Kay SA, Harmer SL (2008) Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development. Genome Biol 9(8):R130
Croce R, van Amerongen H (2014) Natural strategies for photosynthetic light harvesting. Nat Chem Biol 10(7):492–501
Cunningham FX, Gantt E (1998) Genes and enzymes of carotenoid biosynthesis in plants. Annu Rev Plant Physiol Plant Mol Biol 49:557–583
Cunningham FX Jr, Gantt E (2001) One ring or two? Determination of ring number in carotenoids by lycopene epsilon-cyclases. Proc Natl Acad Sci U S A 98(5):2905–2910
Cunningham FX Jr, Pogson B, Sun Z, McDonald KA, DellaPenna D, Gantt E (1996) Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation. Plant Cell 8(9):1613–1626
Cuttriss AJ, Chubb AC, Alawady A, Grimm B, Pogson BJ (2007) Regulation of lutein biosynthesis and prolamellar body formation in Arabidopsis. Funct Plant Biol 34:663–672
Dall’Osto L, Fiore A, Cazzaniga S, Giuliano G, Bassi R (2007) Different roles of alpha- and beta-branch xanthophylls in photosystem assembly and photoprotection. J Biol Chem 282(48):35056–35068
De la Guardia MD, Aragon CM, Murillo FJ, Cerda-Olmedo E (1971) A carotenogenic enzyme aggregate in Phycomyces: evidence from quantitive complementation. Proc Natl Acad Sci U S A 68(9):2012–2015
Demmig-Adams B, Gilmore AM, Adams WW 3rd (1996) In vivo function of carotenoids in higher plants. FASEB J 10(4):403–412
Dodd AN, Salathia N, Hall A, Kevei E, Toth R, Nagy F, Hibberd JM, Millar AJ, Webb AA (2005) Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage. Science 309(5734):630–633
Dong H, Deng Y, Mu J, Lu Q, Wang Y, Xu Y, Chu C, Chong K, Lu C, Zuo J (2007) The Arabidopsis Spontaneous Cell Death1 gene, encoding a zeta-carotene desaturase essential for carotenoid biosynthesis, is involved in chloroplast development, photoprotection and retrograde signalling. Cell Res 17(5):458–470
Dudareva N, Andersson S, Orlova I, Gatto N, Reichelt M, Rhodes D, Boland W, Gershenzon J (2005) The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers. Proc Natl Acad Sci U S A 102(3):933–938
Duek PD, Fankhauser C (2005) bHLH class transcription factors take centre stage in phytochrome signalling. Trends Plant Sci 10(2):51–54
Estevez JM, Cantero A, Reindl A, Reichler S, Leon P (2001) 1-Deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants. J Biol Chem 276(25):22901–22909
Facella P, Lopez L, Carbone F, Galbraith DW, Giuliano G, Perrotta G (2008) Diurnal and circadian rhythms in the tomato transcriptome and their modulation by cryptochrome photoreceptors. PLoS One 3(7):e2798
Fernandez-Gonzalez B, Martinez-Ferez IM, Vioque A (1998) Characterization of two carotenoid gene promoters in the cyanobacterium Synechocystis sp. PCC 6803. Biochim Biophys Acta 1443(3):343–351
Flores-Perez U, Sauret-Gueto S, Gas E, Jarvis P, Rodriguez-Concepcion M (2008) A mutant impaired in the production of plastome-encoded proteins uncovers a mechanism for the homeostasis of isoprenoid biosynthetic enzymes in Arabidopsis plastids. Plant Cell 20(5):1303–1315
Fontes M, Galbis-Martinez L, Murillo FJ (2003) A novel regulatory gene for light-induced carotenoid synthesis in the bacterium Myxococcus xanthus. Mol Microbiol 47(2):561–571
Franklin KA, Larner VS, Whitelam GC (2005) The signal transducing photoreceptors of plants. Int J Dev Biol 49(5–6):653–664
Fraser PD, Bramley PM (2004) The biosynthesis and nutritional uses of carotenoids. Prog Lipid Res 43(3):228–265
Fraser PD, Enfissi EM, Halket JM, Truesdale MR, Yu D, Gerrish C, Bramley PM (2007) Manipulation of phytoene levels in tomato fruit: effects on isoprenoids, plastids, and intermediary metabolism. Plant Cell 19(10):3194–3211
Fraser PD, Schuch W, Bramley PM (2000) Phytoene synthase from tomato (Lycopersicon esculentum) chloroplasts-partial purification and biochemical properties. Planta 211(3):361–369
Frigaard NU, Maresca JA, Yunker CE, Jones AD, Bryant DA (2004) Genetic manipulation of carotenoid biosynthesis in the green sulfur bacterium Chlorobium tepidum. J Bacteriol 186(16):5210–5220
Frosch S, Mohr H (1980) Analysis of light-controlled accumulation of carotenoids in mustard (Sinapis alba L.) seedlings. Planta 148(3):279–286
Frusciante S, Diretto G, Bruno M, Ferrante P, Pietrella M, Prado-Cabrero A, Rubio-Moraga A, Beyer P, Gomez-Gomez L, Al-Babili S, Giuliano G (2014) Novel carotenoid cleavage dioxygenase catalyzes the first dedicated step in saffron crocin biosynthesis. Proc Natl Acad Sci U S A 111(33):12246–12251
Fukushima A, Kusano M, Nakamichi N, Kobayashi M, Hayashi N, Sakakibara H, Mizuno T, Saito K (2009) Impact of clock-associated Arabidopsis pseudo-response regulators in metabolic coordination. Proc Natl Acad Sci U S A 106(17):7251–7256
Ghassemian M, Lutes J, Tepperman JM, Chang HS, Zhu T, Wang X, Quail PH, Lange BM (2006) Integrative analysis of transcript and metabolite profiling data sets to evaluate the regulation of biochemical pathways during photomorphogenesis. Arch Biochem Biophys 448(1–2):45–59
Giliberto L, Perrotta G, Pallara P, Weller JL, Fraser PD, Bramley PM, Fiore A, Tavazza M, Giuliano G (2005) Manipulation of the blue light photoreceptor cryptochrome 2 in tomato affects vegetative development, flowering time, and fruit antioxidant content. Plant Physiol 137(1):199–208
Giuliano G, Al-Babili S, von Lintig J (2003) Carotenoid oxygenases: cleave it or leave it. Trends Plant Sci 8(4):145–149
Harmer SL (2009) The circadian system in higher plants. Annu Rev Plant Biol 60:357–377
Havaux M (2014) Carotenoid oxidation products as stress signals in plants. Plant J 79(4):597–606
Havaux M, Bonfils JP, Lutz C, Niyogi KK (2000) Photodamage of the photosynthetic apparatus and its dependence on the leaf developmental stage in the npq1 Arabidopsis mutant deficient in the xanthophyll cycle enzyme violaxanthin de-epoxidase. Plant Physiol 124(1):273–284
Hedden P, Kamiya Y (1997) Gibberellin biosynthesis: enzymes, genes and their regulation. Annu Rev Plant Physiol Plant Mol Biol 48:431–460
Hieber AD, Bugos RC, Yamamoto HY (2000) Plant lipocalins: violaxanthin de-epoxidase and zeaxanthin epoxidase. Biochim Biophys Acta 1482(1–2):84–91
Hirschberg J (2001) Carotenoid biosynthesis in flowering plants. Curr Opin Plant Biol 4(3):210–218
Holt NE, Zigmantas D, Valkunas L, Li XP, Niyogi KK, Fleming GR (2005) Carotenoid cation formation and the regulation of photosynthetic light harvesting. Science 307(5708):433–436
Hsieh MH, Goodman HM (2005) The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. Plant Physiol 138(2):641–653
Hugueney P, Romer S, Kuntz M, Camara B (1992) Characterization and molecular cloning of a flavoprotein catalyzing the synthesis of phytofluene and zeta-carotene in Capsicum chromoplasts. Eur J Biochem 209(1):399–407
Isaacson T, Ohad I, Beyer P, Hirschberg J (2004) Analysis in vitro of the enzyme CRTISO establishes a poly-cis-carotenoid biosynthesis pathway in plants. Plant Physiol 136(4):4246–4255
Isaacson T, Ronen G, Zamir D, Hirschberg J (2002) Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of beta-carotene and xanthophylls in plants. Plant Cell 14(2):333–342
Kianianmomeni A (2014) Cell-type specific light-mediated transcript regulation in the multicellular alga Volvox carteri. BMC Genomics 15:764
Kim D, Filtz MR, Proteau PJ (2004) The methylerythritol phosphate pathway contributes to carotenoid but not phytol biosynthesis in Euglena gracilis. J Nat Prod 67(6):1067–1069
Kim J, DellaPenna D (2006) Defining the primary route for lutein synthesis in plants: the role of Arabidopsis carotenoid beta-ring hydroxylase CYP97A3. Proc Natl Acad Sci U S A 103(9):3474–3479
Kim J, Smith JJ, Tian L, Dellapenna D (2009) The evolution and function of carotenoid hydroxylases in Arabidopsis. Plant Cell Physiol 50(3):463–479
Klassen JL (2010) Phylogenetic and evolutionary patterns in microbial carotenoid biosynthesis are revealed by comparative genomics. PLoS One 5(6):e11257
Kreuz K, Beyer P, Kleinig H (1982) The site of carotenogenic enzymes in chromoplasts from Narcissus pseudonarcissus L. Planta 154(1):66–69
Krubasik P, Kobayashi M, Sandmann G (2001) Expression and functional analysis of a gene cluster involved in the synthesis of decaprenoxanthin reveals the mechanisms for C50 carotenoid formation. Eur J Biochem 268(13):3702–3708
Krubasik P, Sandmann G (2000) Molecular evolution of lycopene cyclases involved in the formation of carotenoids with ionone end groups. Biochem Soc Trans 28(6):806–810
Lange BM, Rujan T, Martin W, Croteau R (2000) Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. Proc Natl Acad Sci U S A 97(24):13172–13177
Laule O, Furholz A, Chang HS, Zhu T, Wang X, Heifetz PB, Gruissem W, Lange M (2003) Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana. Proc Natl Acad Sci U S A 100(11):6866–6871
Leivar P, Monte E (2014) PIFs: systems integrators in plant development. Plant Cell 26(1):56–78
Leivar P, Quail PH (2011) PIFs: pivotal components in a cellular signaling hub. Trends Plant Sci 16(1):19–28
Leivar P, Tepperman JM, Monte E, Calderon RH, Liu TL, Quail PH (2009) Definition of early transcriptional circuitry involved in light-induced reversal of PIF-imposed repression of photomorphogenesis in young Arabidopsis seedlings. Plant Cell 21(11):3535–3553
Li F, Murillo C, Wurtzel ET (2007) Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization. Plant Physiol 144(2):1181–1189
Li F, Vallabhaneni R, Yu J, Rocheford T, Wurtzel ET (2008) The maize phytoene synthase gene family: overlapping roles for carotenogenesis in endosperm, photomorphogenesis, and thermal stress tolerance. Plant Physiol 147(3):1334–1346
Li Z, Wakao S, Fischer BB, Niyogi KK (2009) Sensing and responding to excess light. Annu Rev Plant Biol 60:239–260
Lichtenthaler HK, Schwender J, Disch A, Rohmer M (1997) Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate-independent pathway. FEBS Lett 400(3):271–274
Lombard J, Moreira D (2011) Origins and early evolution of the mevalonate pathway of isoprenoid biosynthesis in the three domains of life. Mol Biol Evol 28(1):87–99
Lopez AB, Yang Y, Thannhauser TW, Li L (2008) Phytoene desaturase is present in a large protein complex in the plastid membrane. Physiol Plant 133(2):190–198
Lu S, Van Eck J, Zhou X, Lopez AB, O’Halloran DM, Cosman KM, Conlin BJ, Paolillo DJ, Garvin DF, Vrebalov J, Kochian LV, Kupper H, Earle ED, Cao J, Li L (2006) The cauliflower Or gene encodes a DnaJ cysteine-rich domain-containing protein that mediates high levels of beta-carotene accumulation. Plant Cell 18(12):3594–3605
Maass D, Arango J, Wust F, Beyer P, Welsch R (2009) Carotenoid crystal formation in Arabidopsis and carrot roots caused by increased phytoene synthase protein levels. PLoS One 4(7):e6373
Manning K, Tor M, Poole M, Hong Y, Thompson AJ, King GJ, Giovannoni JJ, Seymour GB (2006) A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening. Nat Genet 38(8):948–952
Maresca JA, Graham JE, Bryant DA (2008) The biochemical basis for structural diversity in the carotenoids of chlorophototrophic bacteria. Photosynth Res 97(2):121–140
Marin E, Nussaume L, Quesada A, Gonneau M, Sotta B, Hugueney P, Frey A, Marion-Poll A (1996) Molecular identification of zeaxanthin epoxidase of Nicotiana plumbaginifolia, a gene involved in abscisic acid biosynthesis and corresponding to the ABA locus of Arabidopsis thaliana. EMBO J 15(10):2331–2342
Maudinas B, Bucholtz ML, Papastephanou C, Katiyar SS, Briedis AV, Porter JW (1977) The partial purification and properties of a phytoene synthesizing enzyme system. Arch Biochem Biophys 180(2):354–362
Meier S, Tzfadia O, Vallabhaneni R, Gehring C, Wurtzel ET (2011) A transcriptional analysis of carotenoid, chlorophyll and plastidial isoprenoid biosynthesis genes during development and osmotic stress responses in Arabidopsis thaliana. BMC Syst Biol 5:77
Mialoundama AS, Heintz D, Jadid N, Nkeng P, Rahier A, Deli J, Camara B, Bouvier F (2010) Characterization of plant carotenoid cyclases as members of the flavoprotein family functioning with no net redox change. Plant Physiol 153(3):970–979
Moglich A, Yang X, Ayers RA, Moffat K (2010) Structure and function of plant photoreceptors. Annu Rev Plant Biol 61:21–47
Moise AR, von Lintig J, Palczewski K (2005) Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids. Trends Plant Sci 10(4):178–186
Moise AR, Al-Babili S, Wurtzel ET (2014) Mechanistic aspects of carotenoid biosynthesis. Chem Rev 114(1):164–193
Moran NA, Jarvik T (2010) Lateral transfer of genes from fungi underlies carotenoid production in aphids. Science 328(5978):624–627
Neff MM, Fankhauser C, Chory J (2000) Light: an indicator of time and place. Genes Dev 14(3):257–271
Niyogi KK, Bjorkman O, Grossman AR (1997) The roles of specific xanthophylls in photoprotection. Proc Natl Acad Sci U S A 94(25):14162–14167
Pan Y, Michael TP, Hudson ME, Kay SA, Chory J, Schuler MA (2009) Cytochrome P450 monooxygenases as reporters for circadian-regulated pathways. Plant Physiol 150(2):858–878
Park H, Kreunen SS, Cuttriss AJ, DellaPenna D, Pogson BJ (2002) Identification of the carotenoid isomerase provides insight into carotenoid biosynthesis, prolamellar body formation, and photomorphogenesis. Plant Cell 14(2):321–332
Pecker I, Gabbay R, Cunningham FX Jr, Hirschberg J (1996) Cloning and characterization of the cDNA for lycopene beta-cyclase from tomato reveals decrease in its expression during fruit ripening. Plant Mol Biol 30(4):807–819
Pelz A, Wieland KP, Putzbach K, Hentschel P, Albert K, Gotz F (2005) Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus. J Biol Chem 280(37):32493–32498
Pfannschmidt T, Allen JF, Oelmuller R (2001) Principles of redox control in photosynthesis gene expression. Physiol Plant 112:1–9
Philippar K, Geis T, Ilkavets I, Oster U, Schwenkert S, Meurer J, Soll J (2007) Chloroplast biogenesis: the use of mutants to study the etioplast-chloroplast transition. Proc Natl Acad Sci U S A 104(2):678–683
Phillip D, Young AJ (1995) Occurrence of the carotenoid lactucaxanthin in higher plant LHC II. Photosynth Res 43(3):273–282
Pizarro L, Stange C (2009) Light-dependent regulation of carotenoid biosynthesis in plants. Cienc Inv Agr 36:143–162
Pogson BJ, Niyogi KK, Bjorkman O, DellaPenna D (1998) Altered xanthophyll compositions adversely affect chlorophyll accumulation and nonphotochemical quenching in Arabidopsis mutants. Proc Natl Acad Sci U S A 95(22):13324–13329
Polivka T, Frank HA (2010) Molecular factors controlling photosynthetic light harvesting by carotenoids. Acc Chem Res 43(8):1125–1134
Pulido P, Perello C, Rodriguez-Concepcion M (2012) New insights into plant isoprenoid metabolism. Mol Plant 5(5):964–967
Qin G, Gu H, Ma L, Peng Y, Deng XW, Chen Z, Qu LJ (2007) Disruption of phytoene desaturase gene results in albino and dwarf phenotypes in Arabidopsis by impairing chlorophyll, carotenoid, and gibberellin biosynthesis. Cell Res 17(5):471–482
Quinlan RF, Shumskaya M, Bradbury LM, Beltran J, Ma C, Kennelly EJ, Wurtzel ET (2012) Synergistic interactions between carotene ring hydroxylases drive lutein formation in plant carotenoid biosynthesis. Plant Physiol 160(1):204–214
Raisig A, Sandmann G (2001) Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways. Biochim Biophys Acta 1533(2):164–170
Ramel F, Birtic S, Ginies C, Soubigou-Taconnat L, Triantaphylides C, Havaux M (2012) Carotenoid oxidation products are stress signals that mediate gene responses to singlet oxygen in plants. Proc Natl Acad Sci U S A 109(14):5535–5540
Ramel F, Mialoundama AS, Havaux M (2013) Nonenzymic carotenoid oxidation and photooxidative stress signalling in plants. J Exp Bot 64(3):799–805
Raymond J, Zhaxybayeva O, Gogarten JP, Gerdes SY, Blankenship RE (2002) Whole-genome analysis of photosynthetic prokaryotes. Science 298(5598):1616–1620
Rizzini L, Favory JJ, Cloix C, Faggionato D, O’Hara A, Kaiserli E, Baumeister R, Schäfer E, Nagy F, Jenkins GI, Ulm R (2011) Perception of UV-B by the Arabidopsis UVR8 protein. Science 332(6025):103–106
Rockholm DC, Yamamoto HY (1996) Violaxanthin de-epoxidase. Plant Physiol 110(2):697–703
RodrÃguez-Concepción M (2006) Early steps in isoprenoid biosynthesis: multilevel regulation of the supply of common precursors in plant cells. Phytochem Rev 5:1–15
Rodriguez-Concepcion M, Fores O, Martinez-Garcia JF, Gonzalez V, Phillips MA, Ferrer A, Boronat A (2004) Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. Plant Cell 16(1):144–156
Rodriguez-Villalon A, Gas E, Rodriguez-Concepcion M (2009) Phytoene synthase activity controls the biosynthesis of carotenoids and the supply of their metabolic precursors in dark-grown Arabidopsis seedlings. Plant J 60(3):424–435
Rohmer M, Bouvier P, Ourisson G (1979) Molecular evolution of biomembranes: structural equivalents and phylogenetic precursors of sterols. Proc Natl Acad Sci U S A 76(2):847–851
Romer S, Fraser PD (2005) Recent advances in carotenoid biosynthesis, regulation and manipulation. Planta 221(3):305–308
Rossel JB, Wilson IW, Pogson BJ (2002) Global changes in gene expression in response to high light in Arabidopsis. Plant Physiol 130(3):1109–1120
Rottem S, Markowitz O (1979) Carotenoids acts as reinforcers of the Acholeplasma laidlawii lipid bilayer. J Bacteriol 140(3):944–948
Ruiz-Sola MA, Rodriguez-Concepcion M (2012) Carotenoid biosynthesis in Arabidopsis: a colorful pathway. Arabidopsis Book 10:e0158
Ruzicka L (1953) The isoprene rule and the biogenesis of terpenic compounds. Experientia 9(10):357–367
Sagar AD, Briggs WR (1990) Effects of high light stress on carotenoid-deficient chloroplasts in Pisum sativum. Plant Physiol 94(4):1663–1670
Sandmann G (2002) Molecular evolution of carotenoid biosynthesis from bacteria to plants. Physiol Plant 116:431–440
Sandmann G (2009) Evolution of carotene desaturation: the complication of a simple pathway. Arch Biochem Biophys 483(2):169–174
Sapir-Mir M, Mett A, Belausov E, Tal-Meshulam S, Frydman A, Gidoni D, Eyal Y (2008) Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. Plant Physiol 148(3):1219–1228
Sauret-Gueto S, Botella-Pavia P, Flores-Perez U, Martinez-Garcia JF, San Roman C, Leon P, Boronat A, Rodriguez-Concepcion M (2006) Plastid cues posttranscriptionally regulate the accumulation of key enzymes of the methylerythritol phosphate pathway in Arabidopsis. Plant Physiol 141(1):75–84
Schnurr G, Misawa N, Sandmann G (1996) Expression, purification and properties of lycopene cyclase from Erwinia uredovora. Biochem J 315(Pt 3):869–874
Schuhr CA, Radykewicz T, Sagner S, Latzel C, Zenk MH, Arigoni D, Bacher A, Rohdich F, Eisenreich W (2003) Quantitative assessment of crosstalk between the two isoprenoid biosynthesis pathways in plants by NMR spectroscopy. Phytochem Rev 2:3–16
Schurmann P, Jacquot JP (2000) Plant thioredoxin systems revisited. Annu Rev Plant Physiol Plant Mol Biol 51:371–400
Seymour GB, Ostergaard L, Chapman NH, Knapp S, Martin C (2013) Fruit development and ripening. Annu Rev Plant Biol 64:219–241
Shin J, Kim K, Kang H, Zulfugarov IS, Bae G, Lee CH, Lee D, Choi G (2009) Phytochromes promote seedling light responses by inhibiting four negatively-acting phytochrome-interacting factors. Proc Natl Acad Sci U S A 106(18):7660–7665
Shumskaya M, Wurtzel ET (2013) The carotenoid biosynthetic pathway: thinking in all dimensions. Plant Sci 208:58–63
Sieiro C, Poza M, de Miguel T, Villa TG (2003) Genetic basis of microbial carotenogenesis. Int Microbiol 6(1):11–16
Simkin AJ, Guirimand G, Papon N, Courdavault V, Thabet I, Ginis O, Bouzid S, Giglioli-Guivarc’h N, Clastre M (2011) Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. Planta 234(5):903–914
Simkin AJ, Laboure AM, Kuntz M, Sandmann G (2003a) Comparison of carotenoid content, gene expression and enzyme levels in tomato (Lycopersicon esculentum) leaves. Z Naturforsch C 58(5–6):371–380
Simkin AJ, Zhu C, Kuntz M, Sandmann G (2003b) Light-dark regulation of carotenoid biosynthesis in pepper (Capsicum annuum) leaves. J Plant Physiol 160(5):439–443
Stange C, Flores C (2012) Carotenoids and photosynthesis – regulation of carotenoid biosyntesis by photoreceptors. In: Najafpour MM (ed) Advances in photosynthesis – fundamental aspects. InTech, Rijeka
Steinbrenner J, Linden H (2003) Light induction of carotenoid biosynthesis genes in the green alga Haematococcus pluvialis: regulation by photosynthetic redox control. Plant Mol Biol 52(2):343–356
Stephenson PG, Fankhauser C, Terry MJ (2009) PIF3 is a repressor of chloroplast development. Proc Natl Acad Sci U S A 106(18):7654–7659
Sun TH, Liu CQ, Hui YY, Wu WK, Zhou ZG, Lu S (2010) Coordinated regulation of gene expression for carotenoid metabolism in Chlamydomonas reinhardtii. J Integr Plant Biol 52(10):868–878
Sundstrom V (2008) Femtobiology. Annu Rev Phys Chem 59:53–77
Takano H, Asker D, Beppu T, Ueda K (2006) Genetic control for light-induced carotenoid production in non-phototrophic bacteria. J Ind Microbiol Biotechnol 33(2):88–93
Thompson AJ, Jackson AC, Parker RA, Morpeth DR, Burbidge A, Taylor IB (2000) Abscisic acid biosynthesis in tomato: regulation of zeaxanthin epoxidase and 9-cis-epoxycarotenoid dioxygenase mRNAs by light/dark cycles, water stress and abscisic acid. Plant Mol Biol 42(6):833–845
Timmis JN, Ayliffe MA, Huang CY, Martin W (2004) Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes. Nat Rev Genet 5(2):123–135
Tisch D, Schmoll M (2010) Light regulation of metabolic pathways in fungi. Appl Microbiol Biotechnol 85(5):1259–1277
Toledo-Ortiz G, Huq E, Rodriguez-Concepcion M (2010) Direct regulation of phytoene synthase gene expression and carotenoid biosynthesis by phytochrome-interacting factors. Proc Natl Acad Sci U S A 107(25):11626–11631
Toledo-Ortiz G, Johansson H, Lee KP, Bou-Torrent J, Stewart K, Steel G, Rodriguez-Concepcion M, Halliday KJ (2014) The HY5-PIF regulatory module coordinates light and temperature control of photosynthetic gene transcription. PLoS Genet 10(6):e1004416
Tzvetkova-Chevolleau T, Hutin C, Noel LD, Goforth R, Carde JP, Caffarri S, Sinning I, Groves M, Teulon JM, Hoffman NE, Henry R, Havaux M, Nussaume L (2007) Canonical signal recognition particle components can be bypassed for posttranslational protein targeting in chloroplasts. Plant Cell 19(5):1635–1648
Vershinin A (1999) Biological functions of carotenoids-diversity and evolution. BioFactors 10(2–3):99–104
Villanueva L, Damste JS, Schouten S (2014) A re-evaluation of the archaeal membrane lipid biosynthetic pathway. Nat Rev Microbiol 12(6):438–448
von Lintig J, Welsch R, Bonk M, Giuliano G, Batschauer A, Kleinig H (1997) Light-dependent regulation of carotenoid biosynthesis occurs at the level of phytoene synthase expression and is mediated by phytochrome in Sinapis alba and Arabidopsis thaliana seedlings. Plant J 12(3):625–634
Walter MH, Floss DS, Strack D (2010) Apocarotenoids: hormones, mycorrhizal metabolites and aroma volatiles. Planta 232(1):1–17
Walter MH, Strack D (2011) Carotenoids and their cleavage products: biosynthesis and functions. Nat Prod Rep 28(4):663–692
Welsch R, Beyer P, Hugueney P, Kleinig H, von Lintig J (2000) Regulation and activation of phytoene synthase, a key enzyme in carotenoid biosynthesis, during photomorphogenesis. Planta 211(6):846–854
Welsch R, Wust F, Bar C, Al-Babili S, Beyer P (2008) A third phytoene synthase is devoted to abiotic stress-induced abscisic acid formation in rice and defines functional diversification of phytoene synthase genes. Plant Physiol 147(1):367–380
Wille A, Zimmermann P, Vranova E, Furholz A, Laule O, Bleuler S, Hennig L, Prelic A, von Rohr P, Thiele L, Zitzler E, Gruissem W, Buhlmann P (2004) Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana. Genome Biol 5(11):R92
Woitsch S, Romer S (2003) Expression of xanthophyll biosynthetic genes during light-dependent chloroplast differentiation. Plant Physiol 132(3):1508–1517
Yakir E, Hilman D, Harir Y, Green RM (2007) Regulation of output from the plant circadian clock. FEBS J 274(2):335–345
Yamamoto HY (2006) Functional roles of the major chloroplast lipids in the violaxanthin cycle. Planta 224(3):719–724
Yamamoto HY, Kamite L, Wang YY (1972) An ascorbate-induced absorbance change in chloroplasts from violaxanthin de-epoxidation. Plant Physiol 49(2):224–228
Yu Q, Ghisla S, Hirschberg J, Mann V, Beyer P (2011) Plant carotene cis-trans isomerase CRTISO: a new member of the FAD(RED)-dependent flavoproteins catalyzing non-redox reactions. J Biol Chem 286(10):8666–8676
Yu Q, Schaub P, Ghisla S, Al-Babili S, Krieger-Liszkay A, Beyer P (2010) The lycopene cyclase CrtY from Pantoea ananatis (formerly Erwinia uredovora) catalyzes an FADred-dependent non-redox reaction. J Biol Chem 285(16):12109–12120
Zhong S, Fei Z, Chen YR, Zheng Y, Huang M, Vrebalov J, McQuinn R, Gapper N, Liu B, Xiang J, Shao Y, Giovannoni JJ (2013) Single-base resolution methylomes of tomato fruit development reveal epigenome modifications associated with ripening. Nat Biotechnol 31(2):154–159
Acknowledgments
I am grateful to Manuel RodrÃguez-Concepción for critical reading of this manuscript. My research is mainly funded by the EC Marie Curie research project CarotenActors (FP7-PEOPLE-2011-IIF 300862) and the MINECO Postdoctoral Grant (FPDI-2013-018882). I also acknowledge the support from grants from MINECO (BIO2011-23680) and CYTED (Ibercarot-112RT0445).
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Llorente, B. (2016). Regulation of Carotenoid Biosynthesis in Photosynthetic Organs. In: Stange, C. (eds) Carotenoids in Nature. Subcellular Biochemistry, vol 79. Springer, Cham. https://doi.org/10.1007/978-3-319-39126-7_5
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