Abstract
Hypertrophic cardiomyopathy (HCM) is the most common autosomal dominant inherited cardiac disease with great genetic and clinical heterogeneity. Pregnancy is usually tolerated well, with complications limited to high-risk and symptomatic women. Preconception counseling and risk management are important, because of the inheritance risk and the determination of follow-up during pregnancy. Vaginal delivery is generally preferred, because of the reduced risk of blood loss and infection.
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- ACE:
-
Angiotensin converting enzyme
- ARBs:
-
Angiotensin receptor blockers
- FDA:
-
Food and Drug Administration
- G+:
-
Genotype positive
- HCM:
-
Hypertrophic cardiomyopathy
- ICD:
-
Implantable cardioverter defibrillator
- LV:
-
Left ventricular
- LVOT:
-
Left ventricular outflow tract
- NYHA:
-
New York Heart Association
- SCD:
-
Sudden cardiac death
- VKA:
-
Vitamin K antagonist
- WHO:
-
World Health Organization
References
Elliott PM, Anastasakis A, Borger MA et al (2014) 2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy. Eur Heart J 35:2733–2779
Semsarian C, Ingles J, Maron MS et al (2015) New perspectives on the prevalence of hypertrophic cardiomyopathy. J Am Coll Cardiol 65:1249–1254
Maron BJ, Ommen SR, Semsarian C et al (2014) Hypertrophic cardiomyopathy: present and future, with translation into contemporary cardiovascular medicine. J Am Coll Cardiol 64:83–99
Olivotto I, Cecchi F, Poggesi C et al (2012) Patterns of disease progression in hypertrophic cardiomyopathy: an individualized approach to clinical staging. Circ Heart Fail 5:535–546
Jensen MK, Havndrup O, Christiaensen M, Andersen PS, Diness B, Axelsson A et al (2013) Penetrance of hypertrophic cardiomyopathy in children and adolescents. Circulation 127:48–54
Michels M, Soliman OI, Kofflard MJ, Hoedemaekers YM, Dooijes D, Majoor-Krakauer D et al (2009) Diastolic abnormalities as the first feature of hypertrophic cardiomyopathy in Dutch myosin-binding protein C founder mutations. JACC Cardiovasc Imaging 2:58–64
Maron MS, Olivotto I, Betocchi et al (2003) Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. N Engl Med 348:295–303
O’Mahony C, Jichi F, Pavlou M et al (2014) A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM risk-SCD). Eur Heart J 35:2010–2020
Guttmann OP, Rahman MS, O’Mahony C et al (2014) Atrial fibrillation and thromboembolism in patients with hypertrophic cardiomyopathy: systematic review. Heart 100:465–472
Gersh BJ, Maron BJ, Bonow RO et al (2011) 2011 ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 124(24):e783–e831
Maron MS, Olivotto I, Zenovich A et al (2006) Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction. Circulation 114(21):2232–2239
Wigle ED, Sasson Z, Henderson MA et al (1985) Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review. Prog Cardiovasc Dis 28:1–83
Regitz-Zagrosek V, Blomstrom LC, Borghi C et al (2011) ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). Eur Heart J 32:3147–3197
Autore C, Conte MR, Piccininno (2002) Risk associated with pregnancy in hypertrophic cardiomyopathy. J Am Coll Cardiol 40:1864–1869
Thaman R, Varnava A, Hamid MS et al (2003) Pregnancy related complications in women with hypertrophic cardiomyopathy. Heart 89:752–756
Siu SC, Sermer M, Colman JM et al (2001) Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation 104(5):515–521
Drenthen W, Boersma E, Balci A et al (2010) Predictors of pregnancy complications in women with congenital heart disease. Eur Heart J 31:2124–2132
Silversides CK, Harris L, Haberer K et al (2006) Recurrence rates of arrhythmias during pregnancy in women with previous tachyarrhythmias and impact on fetal and neonatal outcomes. Am J Cardiol 97(8):1206–1212
Lima V, Parikh P, Zhu J et al (2015) Association of cardiomyopathy with adverse cardiac events in pregnant women at the time of delivery. J Am Coll Cardiol HF 3:257–266
Krul SPJ, van der Smagt JJ, van de Berg MP, Sollie KM, Pieper PG, van Spaendonck-Zwarts (2011) Systematic review of pregnancy in women with inherited cardiomyopathies. Eur J Heart Fail 13:584–594
Balci A, Sollie-Szarynska KM, van der Bijl et al (2014) Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease. Heart 100:1373–1381
Stergiopoulous K, Shiang E, Bench T (2011) Pregnancy in patients with pre-existing cardiomyopathies. J Am Coll Cardiol 58:337–350
Christiaans I, Birnie E, Bonsel GJ, Mannens MM, Michels M, Majoor-Krakauer D et al (2011) Manifest disease, risk factors for sudden cardiac death, and cardiac events in a large nationwide cohort of predictively tested hypertrophic cardiomyopathy mutation carriers: determining the best cardiological screening strategy. Eur Heart J 32:1161–1170
Maron BJ, Zipes DP (2005) 36th Bethesda conference: eligibility recommendations for competitive athletes with cardiovascular abnormalities. J Am Coll Cardiol 45:1312–1375
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Michels, M. (2017). Pregnancy in Hypertrophic Cardiomyopathy. In: Roos-Hesselink, J., Johnson, M. (eds) Pregnancy and Congenital Heart Disease. Congenital Heart Disease in Adolescents and Adults. Springer, Cham. https://doi.org/10.1007/978-3-319-38913-4_11
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DOI: https://doi.org/10.1007/978-3-319-38913-4_11
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