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Oxygen Transport to Tissue XXXVIII pp 215–222Cite as

Effects of Antioxidant Supplements (BioPQQ™) on Cerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 923))

Abstract

Pyrroloquinoline quinone (PQQ) is a quinone compound originally identified in methanol-utilizing bacteria and is a cofactor for redox enzymes. At the Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2014, we reported that PQQ disodium salt (BioPQQ™) improved cognitive function in humans, as assessed by the Stroop test. However, the physiological mechanism of PQQ remains unclear. In the present study, we measured regional cerebral blood flow (rCBF) and oxygen metabolism in prefrontal cortex (PFC), before and after administration of PQQ, using time-resolved near-infrared spectroscopy (tNIRS). A total of 20 healthy subjects between 50 and 70 years of age were administered BioPQQ™ (20 mg) or placebo orally once daily for 12 weeks. Hemoglobin (Hb) concentration and absolute tissue oxygen saturation (SO2) in the bilateral PFC were evaluated under resting conditions using tNIRS. We found that baseline concentrations of hemoglobin and total hemoglobin in the right PFC significantly increased after administration of PQQ (p < 0.05). In addition, decreases in SO2 level in the PFC were more pronounced in the PQQ group than in the placebo group (p < 0.05). These results suggest that PQQ causes increased activity in the right PFC associated with increases in rCBF and oxygen metabolism, resulting in enhanced cognitive function.

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Acknowledgments

This research was supported in part by the Strategic Research Foundation Grant-aided Project for Private Universities (S1411017) and a Grant-in-Aid for Exploratory Research (25560356) from the Ministry of Education, Culture, Sports, Sciences, and Technology of Japan. Furthermore, this research was supported through grants from Iing Co., Ltd. (Tokyo, Japan), Alpha Electron Co., Ltd. (Fukushima, Japan), NJI Co., Ltd. (Fukushima, Japan), and Southern Tohoku General Hospital (Fukushima, Japan).

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Authors and Affiliations

  1. Niigata Research Laboratory, Mitsubishi Gas Chemical Co., Inc., Tokyo, Japan

    Masahiko Nakano & Kazuto Ikemoto

  2. Department of Electrical and Electronic Engineering, NEWCAT Research Institute, College of Engineering, Nihon University, 1 Nakagawara, Tokusada, Tamuramachi, Koriyama, Fukushima Prefecture, 963-8642, Japan

    Yuta Murayama, Lizhen Hu & Kaoru Sakatani

  3. CX Medical Japan Co., Inc., Tokyo, Japan

    Tatsuo Uetake

  4. Department of Neurological Surgery, School of Medicine, Nihon University, Tokyo, Japan

    Kaoru Sakatani

Authors
  1. Masahiko Nakano
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  2. Yuta Murayama
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  3. Lizhen Hu
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  4. Kazuto Ikemoto
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  5. Tatsuo Uetake
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  6. Kaoru Sakatani
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Corresponding author

Correspondence to Kaoru Sakatani .

Editor information

Editors and Affiliations

  1. Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

    Qingming Luo

  2. Molecular Imaging Laboratory, Department of Radiology, Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Lin Z. Li

  3. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

  4. Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

    Hua Shi

  5. ISOTT Historian, Ellicott City, Maryland, USA

    Duane F. Bruley

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© 2016 Springer International Publishing Switzerland

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Nakano, M., Murayama, Y., Hu, L., Ikemoto, K., Uetake, T., Sakatani, K. (2016). Effects of Antioxidant Supplements (BioPQQ™) on Cerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex. In: Luo, Q., Li, L., Harrison, D., Shi, H., Bruley, D. (eds) Oxygen Transport to Tissue XXXVIII. Advances in Experimental Medicine and Biology, vol 923. Springer, Cham. https://doi.org/10.1007/978-3-319-38810-6_29

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