Abstract
Structural characterization of protein-protein interactions is essential for fundamental understanding of biomolecular processes and applications in biology and medicine. The number of protein interactions in a genome is significantly larger than the number of individual proteins. Most protein structures have to be models of limited accuracy. The structure-based methods for building the network of protein interactions have to be fast and insensitive to the inaccuracies of the modeled structures. This paper describes our latest development of the docking methodology, including global docking search, scoring and refinement of the predictions, its systematic benchmarking on comprehensive sets of protein structures of different accuracy, and application to the genome-wide networks of protein interactions.
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Acknowledgments
This study was supported by NIH grant R01GM074255 and NSF grant DBI1262621. Calculations were conducted in part on ITTC computer cluster at The University of Kansas.
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Anishchenko, I. et al. (2016). Genome-Wide Structural Modeling of Protein-Protein Interactions. In: Bourgeois, A., Skums, P., Wan, X., Zelikovsky, A. (eds) Bioinformatics Research and Applications. ISBRA 2016. Lecture Notes in Computer Science(), vol 9683. Springer, Cham. https://doi.org/10.1007/978-3-319-38782-6_8
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DOI: https://doi.org/10.1007/978-3-319-38782-6_8
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