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Pathology and Molecular Pathology of Renal Cancer

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Pathology and Epidemiology of Cancer

Abstract

In this chapter, we discuss the development of the parenchymal kidney and its anatomic and histologic compartments. The chapter concentrates on renal cell carcinoma, beginning with renal cell carcinomas with molecular abnormalities and those associated with hereditary syndromes. The remainder of the chapter discusses mesenchymal lesions, familial syndromes, and renal cell carcinomas without known molecular drivers. Renal malignancies can be divided into a wide breadth of histologic subtypes, and the emerging molecular underpinnings pose an evolving challenge in disease categorization and prognostication. While early research relied on the link between familial genetic syndromes and renal cell carcinoma, the direction has shifted to molecular and environmental drivers of sporadic renal cell carcinomas.

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Author information

Authors and Affiliations

  1. David Geffen School of Medicine, UCLA, 10833 Le Conte Ave., PO. Box 951732, CHS Los Angeles, CA, 90095, USA

    Sue Chang

  2. Department of Pathology, Dana Farber Cancer Institute & Brigham & Women’s Hospital, Harvard Medical School, 450 Brookline Avenue., Boston, MA, 02115, USA

    Massimo Loda

Authors
  1. Sue Chang
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  2. Massimo Loda
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Corresponding author

Correspondence to Sue Chang .

Editor information

Editors and Affiliations

  1. Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, Massachusetts, USA

    Massimo Loda

  2. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA

    Lorelei A. Mucci

  3. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA

    Megan L. Mittelstadt

  4. King’s College London, Guy’s Hospital, London, United Kingdom

    Mieke Van Hemelrijck

  5. Department of Pathology, Dana-Farber Cancer Institute and Brigham & Women’s Hospital, Boston, Massachusetts, USA

    Maura Bríd Cotter

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Chang, S., Loda, M. (2017). Pathology and Molecular Pathology of Renal Cancer. In: Loda, M., Mucci, L., Mittelstadt, M., Van Hemelrijck, M., Cotter, M. (eds) Pathology and Epidemiology of Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-35153-7_18

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  • DOI: https://doi.org/10.1007/978-3-319-35153-7_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-35151-3

  • Online ISBN: 978-3-319-35153-7

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