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Pituitary Adenylate Cyclase Activating Polypeptide — PACAP pp 43–50Cite as

PACAP and Learning in Invertebrates

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Part of the book series: Current Topics in Neurotoxicity ((Current Topics Neurotoxicity,volume 11))

Abstract

As one of the greatest achievements of medicine in the twentieth century, there has been a dramatic increase in life expectancy and this tendency continues even more rapidly in the twenty-first century. However, this positive achievement also has some negative consequences. The number of patients with clinical memory deficits, including those associated with Alzheimer’s and Parkinson’s diseases, is also on the rise and there is an urgent need for novel drugs and treatment methods. Neuropeptides are widely distributed in regions of the mammalian brain involved in learning and memory and represent targets of memory research. PACAP is one of the peptides that has been found to be vital in memory formation both in vertebrates and invertebrates and provides a promising avenue for research. The use of genetically and physiologically tractable invertebrate model systems will likely lead to the elucidation of fundamental cellular and molecular processes induced by PACAP, due to the numerical simplicity of the brain structures involved. The fruit fly (Drosophila melanogaster) and the pond snail (Lymnaea stagnalis) are two prominent invertebrate model systems that so far have provided valuable insights into the role of PACAP in ageing and memory-related processes, therefore this chapter concentrates on these species.

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Acknowledgments

I.K.’s original research has been funded by the Biology and Biotechnology Research Council (BBSRC, UK). G.K.’s original research was funded by the Medical Research Council (MRC, UK).

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Authors and Affiliations

  1. Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, BN1 9QG, UK

    Ildiko Kemenes & Gyorgy Kemenes

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  1. Ildiko Kemenes
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  2. Gyorgy Kemenes
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Correspondence to Ildiko Kemenes .

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Editors and Affiliations

  1. Department of Anatomy MTA-PTE “Lendulet” PACAP Research Team, University of Pecs, Pecs, Hungary

    Dora Reglodi

  2. Department of Anatomy MTA-PTE “Lendulet” PACAP Research Team, University of Pecs, Pecs, Hungary

    Andrea Tamas

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Kemenes, I., Kemenes, G. (2016). PACAP and Learning in Invertebrates. In: Reglodi, D., Tamas, A. (eds) Pituitary Adenylate Cyclase Activating Polypeptide — PACAP. Current Topics in Neurotoxicity, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-319-35135-3_4

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