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Diagnosis and Management of Intrahepatic and Extrahepatic Cholangiocarcinoma

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Gastrointestinal Malignancies

Part of the book series: Cancer Treatment and Research ((CTAR))

Abstract

Cholangiocarcinomas (CC) are rare tumors which usually present late and are often difficult to diagnose and treat. CCs are categorized as intrahepatic, hilar, or extrahepatic. Epidemiologic studies suggest that the incidence of intrahepatic CCs may be increasing worldwide. In this chapter, we review the risk factors, clinical presentation, and management of cholangiocarcinoma.

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References

  1. Nakeeb A et al (1996) Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg 224:463–473; discussion 473–475

    Google Scholar 

  2. DeOliveira ML et al (2007) Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg 245:755–762

    Article  PubMed  PubMed Central  Google Scholar 

  3. Patel T (2006) Cholangiocarcinoma. Nat Clin Pract Gastroenterol Hepatol 3:33–42

    Article  PubMed  Google Scholar 

  4. Jhaveri KS, Hosseini-Nik H (2014) MRI of cholangiocarcinoma. J Magn Reson Imaging JMRI. doi:10.1002/jmri.24810

    Google Scholar 

  5. Chung YE et al (2009) Varying appearances of cholangiocarcinoma: radiologic-pathologic correlation. Radiogr Rev Publ Radiol Soc N Am Inc 29:683–700

    Google Scholar 

  6. Lim JH (2003) Cholangiocarcinoma: morphologic classification according to growth pattern and imaging findings. AJR Am J Roentgenol 181:819–827

    Article  PubMed  Google Scholar 

  7. Razumilava N, Gores GJ (2014) Cholangiocarcinoma. Lancet Lond Engl 383:2168–2179

    Article  Google Scholar 

  8. Blechacz B, Komuta M, Roskams T, Gores GJ (2011) Clinical diagnosis and staging of cholangiocarcinoma. Nat Rev Gastroenterol Hepatol 8:512–522

    Article  PubMed  PubMed Central  Google Scholar 

  9. Nakanuma Y, Kakuda Y (2015) Pathologic classification of cholangiocarcinoma: new concepts. Best Pract Res Clin Gastroenterol 29:277–293

    Article  PubMed  Google Scholar 

  10. Lim JH, Park CK (2004) Pathology of cholangiocarcinoma. Abdom Imaging 29:540–547

    CAS  PubMed  Google Scholar 

  11. Chung YE, Kim M-J, Park YN, Lee Y-H, Choi J-Y (2008) Staging of extrahepatic cholangiocarcinoma. Eur Radiol 18:2182–2195

    Article  PubMed  Google Scholar 

  12. Olnes MJ, Erlich R (2004) A review and update on cholangiocarcinoma. Oncology 66:167–179

    Article  PubMed  Google Scholar 

  13. Henson DE, Albores-Saavedra J, Corle D (1992) Carcinoma of the extrahepatic bile ducts. Histologic types, stage of disease, grade, and survival rates. Cancer 70:1498–1501

    Article  CAS  PubMed  Google Scholar 

  14. Shaib Y, El-Serag HB (2004) The epidemiology of cholangiocarcinoma. Semin Liver Dis 24:115–125

    Article  PubMed  Google Scholar 

  15. Charbel H, Al-Kawas FH (2011) Cholangiocarcinoma: epidemiology, risk factors, pathogenesis, and diagnosis. Curr Gastroenterol Rep 13:182–187

    Article  PubMed  Google Scholar 

  16. Patel T (2001) Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology 33:1353–1357

    Article  CAS  PubMed  Google Scholar 

  17. McLean L, Patel T (2006) Racial and ethnic variations in the epidemiology of intrahepatic cholangiocarcinoma in the United States. Liver Int 26:1047–1053

    Article  PubMed  Google Scholar 

  18. Utada M, Ohno Y, Tamaki T, Sobue T, Endo G (2014) Long-term trends in incidence and mortality of intrahepatic and extrahepatic bile duct cancer in Japan. J Epidemiol Jpn Epidemiol Assoc 24:193–199

    Article  Google Scholar 

  19. Altekruse SF et al (2015) Geographic variation of intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and hepatocellular carcinoma in the United States. PLoS ONE 10:e0120574

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  20. Shin H-R et al (2010) Comparison of incidence of intrahepatic and extrahepatic cholangiocarcinoma–focus on East and South-Eastern Asia. Asian Pac J Cancer Prev APJCP 11:1159–1166

    PubMed  Google Scholar 

  21. Khan SA et al (2002) Changing international trends in mortality rates for liver, biliary and pancreatic tumours. J Hepatol 37:806–813

    Article  PubMed  Google Scholar 

  22. Khan SA, Toledano MB, Taylor-Robinson SD (2008) Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma. HPB 10:77–82

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Tyson GL et al (2014) Secular trends in the incidence of cholangiocarcinoma in the USA and the impact of misclassification. Dig Dis Sci 59:3103–3110

    Article  PubMed  PubMed Central  Google Scholar 

  24. Taylor-Robinson SD et al (2001) Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968–1998. Gut 48:816–820

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. West J, Wood H, Logan RFA, Quinn M, Aithal GP (2006) Trends in the incidence of primary liver and biliary tract cancers in England and Wales 1971–2001. Br J Cancer 94:1751–1758

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Shaib YH, Davila JA, McGlynn K, El-Serag HB (2004) Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase? J Hepatol 40:472–477

    Article  PubMed  Google Scholar 

  27. Alvaro D et al (2010) Descriptive epidemiology of cholangiocarcinoma in Italy. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver 42:490–495

    Google Scholar 

  28. von Hahn T et al (2011) Epidemiological trends in incidence and mortality of hepatobiliary cancers in Germany. Scand J Gastroenterol 46:1092–1098

    Article  Google Scholar 

  29. Witjes CDM et al (2012) Intrahepatic cholangiocarcinoma in a low endemic area: rising incidence and improved survival. HPB 14:777–781

    Article  PubMed  PubMed Central  Google Scholar 

  30. Desmond MK, Wong LL (2015) Cholangiocarcinoma: a pan-Pacific perspective. Am Surg 81:E181–E183

    PubMed  Google Scholar 

  31. Njei B (2014) Changing pattern of epidemiology in intrahepatic cholangiocarcinoma. Hepatol Baltim Md 60:1107–1108

    Article  Google Scholar 

  32. Endo I et al (2008) Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection. Ann Surg 248:84–96

    Article  PubMed  Google Scholar 

  33. Jepsen P, Vilstrup H, Tarone RE, Friis S, Sørensen HT (2007) Incidence rates of intra- and extrahepatic cholangiocarcinomas in Denmark from 1978 through 2002. J Natl Cancer Inst 99:895–897

    Article  PubMed  Google Scholar 

  34. Lepage C et al (2011) Trends in the incidence and management of biliary tract cancer: a French population-based study. J Hepatol 54:306–310

    Article  PubMed  Google Scholar 

  35. Matull W-R, Khan SA, Pereira SP (2007) Re: Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on incidence of intra- and extrahepatic cholangiocarcinoma in the United States. J Natl Cancer Inst 99:407; author reply 407–408

    Google Scholar 

  36. Welzel TM, McGlynn KA, Hsing AW, O’Brien TR, Pfeiffer RM (2006) Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States. J Natl Cancer Inst 98:873–875

    Article  PubMed  Google Scholar 

  37. Khan SA et al (2012) Rising trends in cholangiocarcinoma: is the ICD classification system misleading us? J Hepatol 56:848–854

    Article  PubMed  Google Scholar 

  38. Bergquist A, von Seth E (2015) Epidemiology of cholangiocarcinoma. Best Pract Res Clin Gastroenterol 29:221–232

    Article  PubMed  Google Scholar 

  39. Tyson GL, El-Serag HB (2011) Risk factors for cholangiocarcinoma. Hepatol Baltim Md 54:173–184

    Article  CAS  Google Scholar 

  40. Khan SA et al (2012) Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update. Gut 61:1657–1669

    Article  CAS  PubMed  Google Scholar 

  41. Boonstra K et al (2013) Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis. Hepatol Baltim Md 58:2045–2055

    Article  CAS  Google Scholar 

  42. Lazaridis KN, Gores GJ (2006) Primary sclerosing cholangitis and cholangiocarcinoma. Semin Liver Dis 26:42–51

    Article  CAS  PubMed  Google Scholar 

  43. Claessen MMH, Vleggaar FP, Tytgat KMAJ, Siersema PD, van Buuren HR (2009) High lifetime risk of cancer in primary sclerosing cholangitis. J Hepatol 50:158–164

    Article  PubMed  Google Scholar 

  44. Boberg KM, Lind GE (2011) Primary sclerosing cholangitis and malignancy. Best Pract Res Clin Gastroenterol 25:753–764

    Article  PubMed  Google Scholar 

  45. de Valle MB, Björnsson E, Lindkvist B (2012) Mortality and cancer risk related to primary sclerosing cholangitis in a Swedish population-based cohort. Liver Int Off J Int Assoc Study Liver 32:441–448

    Article  CAS  Google Scholar 

  46. Broome U et al (1996) Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis. Gut 38:610–615

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Pitt HA, Dooley WC, Yeo CJ, Cameron JL (1995) Malignancies of the biliary tree. Curr Probl Surg 32:1–90

    Article  CAS  PubMed  Google Scholar 

  48. Liu R et al (2014) Cholangiocarcinoma and high-grade dysplasia in young patients with primary sclerosing cholangitis. Dig Dis Sci 59:2320–2324

    Article  CAS  PubMed  Google Scholar 

  49. Boberg KM et al (2002) Cholangiocarcinoma in primary sclerosing cholangitis: risk factors and clinical presentation. Scand J Gastroenterol 37:1205–1211

    Article  CAS  PubMed  Google Scholar 

  50. Chapman MH et al (2012) Cholangiocarcinoma and dominant strictures in patients with primary sclerosing cholangitis: a 25-year single-centre experience. Eur J Gastroenterol Hepatol 24:1051–1058

    Article  PubMed  PubMed Central  Google Scholar 

  51. Chalasani N et al (2000) Cholangiocarcinoma in patients with primary sclerosing cholangitis: a multicenter case-control study. Hepatology 31:7–11

    Article  CAS  PubMed  Google Scholar 

  52. Burak K et al (2004) Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis. Am J Gastroenterol 99:523–526

    Article  PubMed  Google Scholar 

  53. Watanapa P, Watanapa WB (2002) Liver fluke-associated cholangiocarcinoma. Br J Surg 89:962–970

    Article  CAS  PubMed  Google Scholar 

  54. Shin H-R et al (2010) Epidemiology of cholangiocarcinoma: an update focusing on risk factors. Cancer Sci 101:579–585

    Article  CAS  PubMed  Google Scholar 

  55. Sithithaworn P, Yongvanit P, Duenngai K, Kiatsopit N, Pairojkul C (2014) Roles of liver fluke infection as risk factor for cholangiocarcinoma. J Hepato-Biliary-Pancreat Sci 21:301–308

    Article  Google Scholar 

  56. Qian M-B, Chen Y-D, Liang S, Yang G-J, Zhou X-N (2012) The global epidemiology of clonorchiasis and its relation with cholangiocarcinoma. Infect Dis Poverty 1:4

    Article  PubMed  PubMed Central  Google Scholar 

  57. Sriamporn S et al (2004) Prevalence of Opisthorchis viverrini infection and incidence of cholangiocarcinoma in Khon Kaen, Northeast Thailand. Trop Med Int Health TM IH 9:588–594

    Article  CAS  PubMed  Google Scholar 

  58. Choi BI, Han JK, Hong ST, Lee KH (2004) Clonorchiasis and cholangiocarcinoma: etiologic relationship and imaging diagnosis. Clin Microbiol Rev 17:540–552, table of contents

    Google Scholar 

  59. Sripa B et al (2012) The tumorigenic liver fluke Opisthorchis viverrini–multiple pathways to cancer. Trends Parasitol 28:395–407

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Shoda J, Tanaka N, Osuga T (2003) Hepatolithiasis–epidemiology and pathogenesis update. Front Biosci J Virtual Libr 8:e398–e409

    Article  CAS  Google Scholar 

  61. Kubo S, Kinoshita H, Hirohashi K, Hamba H (1995) Hepatolithiasis associated with cholangiocarcinoma. World J Surg 19:637–641

    Article  CAS  PubMed  Google Scholar 

  62. Chen MF (1999) Peripheral cholangiocarcinoma (cholangiocellular carcinoma): clinical features, diagnosis and treatment. J Gastroenterol Hepatol 14:1144–1149

    Article  CAS  PubMed  Google Scholar 

  63. Okuda K, Nakanuma Y, Miyazaki M (2002) Cholangiocarcinoma: recent progress. Part 1: epidemiology and etiology. J Gastroenterol Hepatol 17:1049–1055

    Article  PubMed  Google Scholar 

  64. Tanaka M et al (2010) Risk factors for intrahepatic cholangiocarcinoma: a possible role of hepatitis B virus. J Viral Hepat 17:742–748

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Zhou Y et al (2012) Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis. BMC Cancer 12:289

    Article  PubMed  PubMed Central  Google Scholar 

  66. Li M et al (2012) Hepatitis B virus infection increases the risk of cholangiocarcinoma: a meta-analysis and systematic review. J Gastroenterol Hepatol 27:1561–1568

    Article  PubMed  Google Scholar 

  67. Ralphs S, Khan SA (2013) The role of the hepatitis viruses in cholangiocarcinoma. J Viral Hepat 20:297–305

    Article  CAS  PubMed  Google Scholar 

  68. Zhou H-B, Hu J-Y, Hu H-P (2014) Hepatitis B virus infection and intrahepatic cholangiocarcinoma. World J Gastroenterol WJG 20:5721–5729

    Article  PubMed  Google Scholar 

  69. Li H et al (2015) Hepatitis C virus infection and the risk of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma: evidence from a systematic review and meta-analysis of 16 case-control studies. World J Surg Oncol 13:161

    Article  PubMed  PubMed Central  Google Scholar 

  70. Plentz RR, Malek NP (2015) Clinical presentation, risk factors and staging systems of cholangiocarcinoma. Best Pract Res Clin Gastroenterol 29:245–252

    Article  PubMed  Google Scholar 

  71. Peng N-F et al (2011) Evaluation of risk factors and clinicopathologic features for intrahepatic cholangiocarcinoma in Southern China: a possible role of hepatitis B virus. Ann Surg Oncol 18:1258–1266

    Article  PubMed  Google Scholar 

  72. Khan SA, Carmichael PL, Taylor-Robinson SD, Habib N, Thomas HC (2003) DNA adducts, detected by 32P postlabelling, in human cholangiocarcinoma. Gut 52:586–591

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Sahani D et al (2003) Thorotrast-induced cholangiocarcinoma: case report. Abdom Imaging 28:72–74

    Article  CAS  PubMed  Google Scholar 

  74. Walker NJ et al (2005) Dose-additive carcinogenicity of a defined mixture of ‘dioxin-like compounds’. Environ Health Perspect 113:43–48

    Article  CAS  PubMed  Google Scholar 

  75. Bond GG et al (1990) Liver and biliary tract cancer among chemical workers. Am J Ind Med 18:19–24

    Article  CAS  PubMed  Google Scholar 

  76. Chapman RW (1999) Risk factors for biliary tract carcinogenesis. Ann Oncol 10(Suppl 4):308–311

    Article  PubMed  Google Scholar 

  77. Simeone D (1999) In Yamada T (ed) Textbook of gastroenterology. Lippincott Williams and Wilkins, pp 2244–2257

    Google Scholar 

  78. Katabi N, Pillarisetty VG, DeMatteo R, Klimstra DS (2014) Choledochal cysts: a clinicopathologic study of 36 cases with emphasis on the morphologic and the immunohistochemical features of premalignant and malignant alterations. Hum Pathol 45:2107–2114

    Article  CAS  PubMed  Google Scholar 

  79. Lipsett PA, Pitt HA, Colombani PM, Boitnott JK, Cameron JL (1994) Choledochal cyst disease. A changing pattern of presentation. Ann Surg 220:644–652

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Scott J, Shousha S, Thomas HC, Sherlock S (1980) Bile duct carcinoma: a late complication of congenital hepatic fibrosis. Case report and review of literature. Am J Gastroenterol 73:113–119

    CAS  PubMed  Google Scholar 

  81. Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD (2005) Cholangiocarcinoma. Lancet 366:1303–1314

    Article  PubMed  Google Scholar 

  82. Ohtsuka T et al (2001) Carcinoma arising in choledochocele. Endoscopy 33:614–619

    Article  CAS  PubMed  Google Scholar 

  83. Huai J-P, Ding J, Ye X-H, Chen Y-P (2014) Inflammatory bowel disease and risk of cholangiocarcinoma: evidence from a meta-analysis of population-based studies. Asian Pac J Cancer Prev APJCP 15:3477–3482

    Article  PubMed  Google Scholar 

  84. Tsai M-S, Lee P-H, Lin C-L, Peng C-L, Kao C-H (2015) Type II diabetes mellitus is associated with a reduced risk of cholangiocarcinoma in patients with biliary tract diseases. Int J Cancer J Int Cancer 136:2409–2417

    Article  CAS  Google Scholar 

  85. Li J-S et al (2014) Obesity and the risk of cholangiocarcinoma: a meta-analysis. Tumour Biol J Int Soc Oncodevelopmental Biol Med 35:6831–6838

    Article  CAS  Google Scholar 

  86. Khan SA et al (2002) Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus document. Gut 51 Suppl 6:VI1–VI9

    Google Scholar 

  87. Hammill CW, Wong LL (2008) Intrahepatic cholangiocarcinoma: a malignancy of increasing importance. J Am Coll Surg 207:594–603

    Article  PubMed  Google Scholar 

  88. Foley WD, Quiroz FA (2007) The role of sonography in imaging of the biliary tract. Ultrasound Q. 23:123–135

    Article  PubMed  Google Scholar 

  89. O’Neill EK, Cogley JR, Miller FH (2015) The ins and outs of liver imaging. Clin Liver Dis 19:99–121

    Article  PubMed  Google Scholar 

  90. Madhusudhan KS, Gamanagatti S, Gupta AK (2015) Imaging and interventions in hilar cholangiocarcinoma: a review. World J. Radiol. 7:28–44

    Article  PubMed  PubMed Central  Google Scholar 

  91. Weber A, Schmid RM, Prinz C (2008) Diagnostic approaches for cholangiocarcinoma. World J Gastroenterol 14:4131–4136

    Article  PubMed  PubMed Central  Google Scholar 

  92. Kong W-T et al (2014) Contribution of contrast-enhanced sonography in the detection of intrahepatic cholangiocarcinoma. J Ultrasound Med Off J Am Inst Ultrasound Med 33:215–220

    Google Scholar 

  93. Galassi M et al (2013) Patterns of appearance and risk of misdiagnosis of intrahepatic cholangiocarcinoma in cirrhosis at contrast enhanced ultrasound. Liver Int Off J Int Assoc Study Liver 33:771–779

    Article  CAS  Google Scholar 

  94. Ringe KI, Wacker F (2015) Radiological diagnosis in cholangiocarcinoma: application of computed tomography, magnetic resonance imaging, and positron emission tomography. Best Pract Res Clin Gastroenterol 29:253–265

    Article  PubMed  Google Scholar 

  95. Ariff B et al (2009) Imaging of liver cancer. World J Gastroenterol WJG 15:1289–1300

    Article  PubMed  Google Scholar 

  96. Ruys AT et al (2012) Radiological staging in patients with hilar cholangiocarcinoma: a systematic review and meta-analysis. Br J Radiol 85:1255–1262

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Aloia TA et al (2007) High-resolution computed tomography accurately predicts resectability in hilar cholangiocarcinoma. Am J Surg 193:702–706

    Article  PubMed  Google Scholar 

  98. Choi BI, Lee JM, Han JK (2004) Imaging of intrahepatic and hilar cholangiocarcinoma. Abdom Imaging 29:548–557

    CAS  PubMed  Google Scholar 

  99. Engelbrecht MR, Katz SS, van Gulik TM, Laméris JS, van Delden OM (2015) Imaging of perihilar cholangiocarcinoma. AJR Am J Roentgenol 204:782–791

    Article  PubMed  Google Scholar 

  100. Seo H et al (2009) Evaluation of the gross type and longitudinal extent of extrahepatic cholangiocarcinomas on contrast-enhanced multidetector row computed tomography. J Comput Assist Tomogr 33:376–382

    Article  PubMed  Google Scholar 

  101. Akamatsu N et al (2010) Diagnostic accuracy of multidetector-row computed tomography for hilar cholangiocarcinoma. J Gastroenterol Hepatol 25:731–737

    Article  PubMed  Google Scholar 

  102. Senda Y et al (2009) Value of multidetector row CT in the assessment of longitudinal extension of cholangiocarcinoma: correlation between MDCT and microscopic findings. World J Surg 33:1459–1467

    Article  PubMed  Google Scholar 

  103. Watadani T, Akahane M, Yoshikawa T, Ohtomo K (2008) Preoperative assessment of hilar cholangiocarcinoma using multidetector-row CT: correlation with histopathological findings. Radiat Med 26:402–407

    Article  PubMed  Google Scholar 

  104. Endo I et al (2007) Role of three-dimensional imaging in operative planning for hilar cholangiocarcinoma. Surgery 142:666–675

    Article  PubMed  Google Scholar 

  105. Unno M et al (2007) Preoperative assessment of hilar cholangiocarcinoma by multidetector row computed tomography. J Hepatobiliary Pancreat Surg 14:434–440

    Article  PubMed  Google Scholar 

  106. Manfredi R, Barbaro B, Masselli G, Vecchioli A, Marano P (2004) Magnetic resonance imaging of cholangiocarcinoma. Semin Liver Dis 24:155–164

    Article  PubMed  Google Scholar 

  107. Vilgrain V et al (1997) Intrahepatic cholangiocarcinoma: MRI and pathologic correlation in 14 patients. J Comput Assist Tomogr 21:59–65

    Article  CAS  PubMed  Google Scholar 

  108. Halefoglu AM (2008) Magnetic resonance cholangiopancreatography. Semin Roentgenol 43:282–289

    Article  Google Scholar 

  109. Zhang Y et al (1999) Intrahepatic peripheral cholangiocarcinoma: comparison of dynamic CT and dynamic MRI. J Comput Assist Tomogr 23:670–677

    Article  CAS  PubMed  Google Scholar 

  110. Yeh TS et al (2000) Malignant perihilar biliary obstruction: magnetic resonance cholangiopancreatographic findings. Am J Gastroenterol 95:432–440

    Article  CAS  PubMed  Google Scholar 

  111. Manfredi R et al (2003) MR imaging and MRCP of hilar cholangiocarcinoma. Abdom Imaging 28:319–325

    Article  CAS  PubMed  Google Scholar 

  112. Cho ES, Park MS, Yu JS, Kim MJ, Kim KW (2007) Biliary ductal involvement of hilar cholangiocarcinoma: multidetector computed tomography versus magnetic resonance cholangiography. J Comput Assist Tomogr 31:72–78

    Article  PubMed  Google Scholar 

  113. Park HS et al (2008) Preoperative evaluation of bile duct cancer: MRI combined with MR cholangiopancreatography versus MDCT with direct cholangiography. AJR Am J Roentgenol 190:396–405

    Article  PubMed  Google Scholar 

  114. Zidi SH, Prat F, Le Guen O, Rondeau Y, Pelletier G (2000) Performance characteristics of magnetic resonance cholangiography in the staging of malignant hilar strictures. Gut 46:103–106

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  115. Sarmiento JM, Nagorney DM (2002) Hepatic resection in the treatment of perihilar cholangiocarcinoma. Surg Oncol Clin N Am 11:893–908, viii–ix

    Google Scholar 

  116. Baron TH (2014) Endoscopic retrograde cholangiopancreatography for cholangiocarcinoma. Clin Liver Dis 18:891–897

    Article  PubMed  Google Scholar 

  117. Nguyen K, Sing J-T (2008) Review of endoscopic techniques in the diagnosis and management of cholangiocarcinoma. World J Gastroenterol WJG 14:2995–2999

    Article  PubMed  Google Scholar 

  118. Weilert F et al (2014) EUS-FNA is superior to ERCP-based tissue sampling in suspected malignant biliary obstruction: results of a prospective, single-blind, comparative study. Gastrointest Endosc 80:97–104

    Article  PubMed  Google Scholar 

  119. Strongin A, Singh H, Eloubeidi MA, Siddiqui AA (2013) Role of endoscopic ultrasonography in the evaluation of extrahepatic cholangiocarcinoma. Endosc Ultrasound 2:71–76

    Article  PubMed  PubMed Central  Google Scholar 

  120. Levy MJ, Heimbach JK, Gores GJ (2012) Endoscopic ultrasound staging of cholangiocarcinoma. Curr Opin Gastroenterol 28:244–252

    Article  PubMed  Google Scholar 

  121. Tamada K, Inui K, Menzel J (2001) Intraductal ultrasonography of the bile duct system. Endoscopy 33:878–885

    Article  CAS  PubMed  Google Scholar 

  122. Nakazawa T, Naitoh I, Hayashi K (2012) Usefulness of intraductal ultrasonography in the diagnosis of cholangiocarcinoma and IgG4-related sclerosing cholangitis. Clin Endosc 45:331–336

    Article  PubMed  PubMed Central  Google Scholar 

  123. Noda Y et al (2008) Intraductal ultrasonography before biliary drainage and transpapillary biopsy in assessment of the longitudinal extent of bile duct cancer. Dig Endosc 20:73–78

    Article  Google Scholar 

  124. Choi ER et al (2011) Preoperative evaluation of the longitudinal extent of borderline resectable hilar cholangiocarcinoma by intraductal ultrasonography. J Gastroenterol Hepatol 26:1804–1810

    Article  PubMed  Google Scholar 

  125. Kim HM et al (2010) Intraductal ultrasonography combined with percutaneous transhepatic cholangioscopy for the preoperative evaluation of longitudinal tumor extent in hilar cholangiocarcinoma. J Gastroenterol Hepatol 25:286–292

    Article  PubMed  Google Scholar 

  126. Nimura Y, Kamiya J, Hayakawa N, Shionoya S (1989) Cholangioscopic differentiation of biliary strictures and polyps. Endoscopy 21(Suppl 1):351–356

    Article  PubMed  Google Scholar 

  127. Tischendorf JJ et al (2006) Cholangioscopic characterization of dominant bile duct stenoses in patients with primary sclerosing cholangitis. Endoscopy 38:665–669

    Article  CAS  PubMed  Google Scholar 

  128. Siddique I et al (1999) The role of choledochoscopy in the diagnosis and management of biliary tract diseases. Gastrointest Endosc 50:67–73

    Article  CAS  PubMed  Google Scholar 

  129. Fukuda Y, Tsuyuguchi T, Sakai Y, Tsuchiya S, Saisyo H (2005) Diagnostic utility of peroral cholangioscopy for various bile-duct lesions. Gastrointest Endosc 62:374–382

    Article  PubMed  Google Scholar 

  130. Caldwell SH, Oelsner DH, Bickston SJ, Mays K, Yeaton P (1996) Intrahepatic biliary endoscopy in sclerosing cholangitis. J Clin Gastroenterol 23:152–156

    Article  CAS  PubMed  Google Scholar 

  131. Williamson JB, Draganov PV (2012) The usefulness of SpyGlassTM choledochoscopy in the diagnosis and treatment of biliary disorders. Curr Gastroenterol Rep 14:534–541

    Article  CAS  PubMed  Google Scholar 

  132. Lan BY, Kwee SA, Wong LL (2012) Positron emission tomography in hepatobiliary and pancreatic malignancies: a review. Am J Surg 204:232–241

    Article  PubMed  PubMed Central  Google Scholar 

  133. Corvera CU et al (2008) 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer. J Am Coll Surg 206:57–65

    Article  PubMed  Google Scholar 

  134. Jadvar H, Henderson RW, Conti PS (2007) [F-18]fluorodeoxyglucose positron emission tomography and positron emission tomography: computed tomography in recurrent and metastatic cholangiocarcinoma. J Comput Assist Tomogr 31:223–228

    Article  PubMed  Google Scholar 

  135. Anderson CD et al (2004) Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma. J Gastrointest Surg 8:90–97

    Article  PubMed  Google Scholar 

  136. Annunziata S et al (2014) Diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography in the evaluation of the primary tumor in patients with cholangiocarcinoma: a meta-analysis. BioMed Res Int 2014:247693

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  137. Lee SW et al (2010) Clinical usefulness of 18F-FDG PET-CT for patients with gallbladder cancer and cholangiocarcinoma. J Gastroenterol 45:560–566

    Article  PubMed  Google Scholar 

  138. Kato T et al (2002) Clinical role of (18)F-FDG PET for initial staging of patients with extrahepatic bile duct cancer. Eur J Nucl Med Mol Imaging 29:1047–1054

    Article  CAS  PubMed  Google Scholar 

  139. Kim JY et al (2008) Clinical role of 18F-FDG PET-CT in suspected and potentially operable cholangiocarcinoma: a prospective study compared with conventional imaging. Am J Gastroenterol 103:1145–1151

    Article  PubMed  Google Scholar 

  140. Park TG et al (2014) Implication of lymph node metastasis detected on 18F-FDG PET/CT for surgical planning in patients with peripheral intrahepatic cholangiocarcinoma. Clin Nucl Med 39:1–7

    Article  PubMed  Google Scholar 

  141. Petrowsky H et al (2006) Impact of integrated positron emission tomography and computed tomography on staging and management of gallbladder cancer and cholangiocarcinoma. J Hepatol 45:43–50

    Article  PubMed  Google Scholar 

  142. Kluge R et al (2001) Positron emission tomography with [(18)F]fluoro-2-deoxy-D-glucose for diagnosis and staging of bile duct cancer. Hepatology 33:1029–1035

    Article  CAS  PubMed  Google Scholar 

  143. Kim YJ, Yun M, Lee WJ, Kim KS, Lee JD (2003) Usefulness of 18F-FDG PET in intrahepatic cholangiocarcinoma. Eur J Nucl Med Mol Imaging 30:1467–1472

    Article  PubMed  Google Scholar 

  144. Moon CM et al (2008) Usefulness of 18F-fluorodeoxyglucose positron emission tomography in differential diagnosis and staging of cholangiocarcinomas. J Gastroenterol Hepatol 23:759–765

    Article  PubMed  Google Scholar 

  145. Li J et al (2008) Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT. J Surg Oncol 98:438–443

    Article  PubMed  Google Scholar 

  146. Ruys AT et al (2011) FDG-positron emission tomography/computed tomography and standardized uptake value in the primary diagnosis and staging of hilar cholangiocarcinoma. HPB 13:256–262

    Article  PubMed  PubMed Central  Google Scholar 

  147. Fritscher-Ravens A et al (2001) FDG PET in the diagnosis of hilar cholangiocarcinoma. Nucl Med Commun 22:1277–1285

    Article  CAS  PubMed  Google Scholar 

  148. Albazaz R, Patel CN, Chowdhury FU, Scarsbrook AF (2013) Clinical impact of FDG PET-CT on management decisions for patients with primary biliary tumours. Insights Imaging 4:691–700

    Article  PubMed  PubMed Central  Google Scholar 

  149. Weber A et al (2008) Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma. World J Gastroenterol WJG 14:1097–1101

    Article  PubMed  Google Scholar 

  150. Schoefl R et al (1997) Forceps biopsy and brush cytology during endoscopic retrograde cholangiopancreatography for the diagnosis of biliary stenoses. Scand J Gastroenterol 32:363–368

    Article  CAS  PubMed  Google Scholar 

  151. Kipp BR et al (2004) A comparison of routine cytology and fluorescence in situ hybridization for the detection of malignant bile duct strictures. Am J Gastroenterol 99:1675–1681

    Article  PubMed  Google Scholar 

  152. Barr Fritcher EG, Kipp BR, Halling KC, Clayton AC (2014) FISHing for pancreatobiliary tract malignancy in endoscopic brushings enhances the sensitivity of routine cytology. Cytopathol Off J Br Soc Clin Cytol 25:288–301

    CAS  Google Scholar 

  153. Moreno Luna LE et al (2006) Advanced cytologic techniques for the detection of malignant pancreatobiliary strictures. Gastroenterology 131:1064–1072

    Article  PubMed  PubMed Central  Google Scholar 

  154. Nanda A et al (2015) Triple modality testing by endoscopic retrograde cholangiopancreatography for the diagnosis of cholangiocarcinoma. Ther Adv Gastroenterol 8:56–65

    Article  Google Scholar 

  155. Heimbach JK, Sanchez W, Rosen CB, Gores GJ (2011) Trans-peritoneal fine needle aspiration biopsy of hilar cholangiocarcinoma is associated with disease dissemination. HPB 13:356–360

    Article  PubMed  PubMed Central  Google Scholar 

  156. Wannhoff A et al (2013) FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis. J Hepatol 59:1278–1284

    Article  CAS  PubMed  Google Scholar 

  157. Kondo N et al (2014) Elevated perioperative serum CA 19-9 levels are independent predictors of poor survival in patients with resectable cholangiocarcinoma. J Surg Oncol 110:422–429

    Article  CAS  PubMed  Google Scholar 

  158. Li Y et al (2015) Application of Joint Detection of AFP, CA19-9, CA125 and CEA in Identification and Diagnosis of Cholangiocarcinoma. Asian Pac J Cancer Prev APJCP 16:3451–3455

    Article  PubMed  Google Scholar 

  159. Pattanapairoj S et al (2015) Improve discrimination power of serum markers for diagnosis of cholangiocarcinoma using data mining-based approach. Clin Biochem 48:668–673

    Article  CAS  PubMed  Google Scholar 

  160. Haga H, Patel T (2015) Molecular diagnosis of intrahepatic cholangiocarcinoma. J Hepato-Biliary-Pancreat Sci 22:114–123

    Article  Google Scholar 

  161. Zeng X, Tao H (2015) Diagnostic and prognostic serum marker of cholangiocarcinoma (Review). Oncol Lett 9:3–8

    PubMed  Google Scholar 

  162. Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17:1471–1474

    Article  PubMed  Google Scholar 

  163. Farges O et al (2011) AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: by the AFC-IHCC-2009 study group. Cancer 117:2170–2177

    Article  PubMed  Google Scholar 

  164. Nathan H et al (2009) A proposed staging system for intrahepatic cholangiocarcinoma. Ann Surg Oncol 16:14–22

    Article  PubMed  Google Scholar 

  165. Hyder O et al (2014) A nomogram to predict long-term survival after resection for intrahepatic cholangiocarcinoma: an Eastern and Western experience. JAMA Surg. 149:432–438

    Article  PubMed  Google Scholar 

  166. Zhou H et al (2015) A simple and effective prognostic staging system based on clinicopathologic features of intrahepatic cholangiocarcinoma. Am J Cancer Res 5:1831–1843

    CAS  PubMed  PubMed Central  Google Scholar 

  167. Hwang S et al (2015) Prognostic impact of tumor growth type on 7th AJCC staging system for intrahepatic cholangiocarcinoma: a single-center experience of 659 cases. J Gastrointest Surg Off J Soc Surg Aliment Tract 19:1291–1304

    Article  Google Scholar 

  168. Uenishi T et al (2005) Serosal invasion in TNM staging of mass-forming intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg 12:479–483

    Article  PubMed  Google Scholar 

  169. Deoliveira ML et al (2011) New staging system and a registry for perihilar cholangiocarcinoma. Hepatol Baltim Md 53:1363–1371

    Article  Google Scholar 

  170. Chaiteerakij R et al (2014) A new clinically based staging system for perihilar cholangiocarcinoma. Am J Gastroenterol 109:1881–1890

    Article  PubMed  PubMed Central  Google Scholar 

  171. Ebata T et al (2014) Proposal to modify the International Union Against Cancer staging system for perihilar cholangiocarcinomas. Br J Surg 101:79–88

    Article  CAS  PubMed  Google Scholar 

  172. Kwon W et al (2015) Suggestions for improving perihilar cholangiocarcinoma staging based on an evaluation of the seventh edition AJCC system. J Gastrointest Surg Off J Soc Surg Aliment Tract 19:666–674

    Article  Google Scholar 

  173. Koerkamp BG et al (2014) American Joint Committee on Cancer staging for resected perihilar cholangiocarcinoma: a comparison of the 6th and 7th editions. HPB 16:1074–1082

    Article  Google Scholar 

  174. Kiriyama M et al (2015) Prognostic impact of lymph node metastasis in distal cholangiocarcinoma. Br J Surg 102:399–406

    Article  CAS  PubMed  Google Scholar 

  175. Hong S-M et al (2009) Depth of tumor invasion better predicts prognosis than the current American Joint Committee on Cancer T classification for distal bile duct carcinoma. Surgery 146:250–257

    Article  PubMed  PubMed Central  Google Scholar 

  176. Jarnagin WR, Shoup M (2004) Surgical management of cholangiocarcinoma. Semin Liver Dis 24:189–199

    Article  PubMed  Google Scholar 

  177. Joseph S, Connor S, Garden OJ (2008) Staging laparoscopy for cholangiocarcinoma. HPB 10:116–119

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  178. Nagino M et al (2013) Evolution of surgical treatment for perihilar cholangiocarcinoma: a single-center 34-year review of 574 consecutive resections. Ann Surg 258:129–140

    Article  PubMed  Google Scholar 

  179. de Jong MC et al (2012) The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: a multi-institutional analysis of 305 cases. Cancer 118:4737–4747

    Article  PubMed  Google Scholar 

  180. Wu X-S et al (2013) Combined portal vein resection for hilar cholangiocarcinoma: a meta-analysis of comparative studies. J Gastrointest Surg Off J Soc Surg Aliment Tract 17:1107–1115

    Article  Google Scholar 

  181. Ramos E (2013) Principles of surgical resection in hilar cholangiocarcinoma. World J Gastrointest Oncol 5:139–146

    Article  PubMed  PubMed Central  Google Scholar 

  182. Su CH et al (1996) Factors influencing postoperative morbidity, mortality, and survival after resection for hilar cholangiocarcinoma. Ann Surg 223:384–394

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  183. Hochwald SN, Burke EC, Jarnagin WR, Fong Y, Blumgart LH (1999) Association of preoperative biliary stenting with increased postoperative infectious complications in proximal cholangiocarcinoma. Arch Surg Chic Ill 1960(134):261–266

    Article  Google Scholar 

  184. Fang Y et al (2013) Meta-analysis of randomized clinical trials on safety and efficacy of biliary drainage before surgery for obstructive jaundice. Br J Surg 100:1589–1596

    Article  CAS  PubMed  Google Scholar 

  185. van der Gaag NA et al (2009) Preoperative biliary drainage in patients with obstructive jaundice: history and current status. J Gastrointest Surg Off J Soc Surg Aliment Tract 13:814–820

    Article  Google Scholar 

  186. Saxena P, Kumbhari V, Zein MEL, Khashab MA (2015) Preoperative biliary drainage. Dig Endosc Off J Jpn Gastroenterol Endosc Soc 27:265–277

    Google Scholar 

  187. Iacono C et al (2013) Role of preoperative biliary drainage in jaundiced patients who are candidates for pancreatoduodenectomy or hepatic resection: highlights and drawbacks. Ann Surg 257:191–204

    Article  PubMed  Google Scholar 

  188. Nagino M et al (2008) Preoperative biliary drainage for biliary tract and ampullary carcinomas. J Hepatobiliary Pancreat Surg 15:25–30

    Article  PubMed  PubMed Central  Google Scholar 

  189. Nimura Y (2008) Preoperative biliary drainage before resection for cholangiocarcinoma (Pro). HPB 10:130–133

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  190. Paik WH, Loganathan N, Hwang J-H (2014) Preoperative biliary drainage in hilar cholangiocarcinoma: when and how? World J Gastrointest Endosc 6:68–73

    Article  PubMed  PubMed Central  Google Scholar 

  191. Maguchi H et al (2007) Preoperative biliary drainage for hilar cholangiocarcinoma. J Hepatobiliary Pancreat Surg 14:441–446

    Article  PubMed  Google Scholar 

  192. Kim KM et al (2015) A comparison of preoperative biliary drainage methods for perihilar cholangiocarcinoma: endoscopic versus percutaneous transhepatic biliary drainage. Gut Liver. doi:10.5009/gnl14243

    Google Scholar 

  193. Hirano S et al (2014) Oncological benefit of preoperative endoscopic biliary drainage in patients with hilar cholangiocarcinoma. J Hepato-Biliary-Pancreat Sci 21:533–540

    Article  Google Scholar 

  194. Kawakami H et al (2011) Endoscopic nasobiliary drainage is the most suitable preoperative biliary drainage method in the management of patients with hilar cholangiocarcinoma. J Gastroenterol 46:242–248

    Article  PubMed  Google Scholar 

  195. Wiggers JK et al (2015) Percutaneous preoperative biliary drainage for resectable perihilar cholangiocarcinoma: no association with survival and no increase in seeding metastases. Ann Surg Oncol. doi:10.1245/s10434-015-4676-z

    Google Scholar 

  196. Kamiya S et al (2004) The value of bile replacement during external biliary drainage: an analysis of intestinal permeability, integrity, and microflora. Ann Surg 239:510–517

    Article  PubMed  PubMed Central  Google Scholar 

  197. Yokoyama Y et al (2007) Recent advances in the treatment of hilar cholangiocarcinoma: portal vein embolization. J Hepatobiliary Pancreat Surg 14:447–454

    Article  PubMed  Google Scholar 

  198. Anaya DA, Blazer DG, Abdalla EK (2008) Strategies for resection using portal vein embolization: hepatocellular carcinoma and hilar cholangiocarcinoma. Semin Interv Radiol 25:110–122

    Article  Google Scholar 

  199. Kennedy TJ et al (2009) Role of preoperative biliary drainage of liver remnant prior to extended liver resection for hilar cholangiocarcinoma. HPB 11:445–451

    Article  PubMed  PubMed Central  Google Scholar 

  200. Poruk KE, Pawlik TM, Weiss MJ (2015) Perioperative management of hilar cholangiocarcinoma. J Gastrointest Surg Off J Soc Surg Aliment Tract. doi:10.1007/s11605-015-2854-8

    Google Scholar 

  201. Ebata T et al (2012) Portal vein embolization before extended hepatectomy for biliary cancer: current technique and review of 494 consecutive embolizations. Dig Surg 29:23–29

    Article  PubMed  Google Scholar 

  202. Higuchi R, Yamamoto M (2014) Indications for portal vein embolization in perihilar cholangiocarcinoma. J Hepato-Biliary-Pancreat Sci 21:542–549

    Article  Google Scholar 

  203. Grendar J, Grendarova P, Sinha R, Dixon E (2014) Neoadjuvant therapy for downstaging of locally advanced hilar cholangiocarcinoma: a systematic review. HPB 16:297–303

    Article  PubMed  Google Scholar 

  204. Ramírez-Merino N, Aix SP, Cortés-Funes H (2013) Chemotherapy for cholangiocarcinoma: an update. World J Gastrointest Oncol 5:171–176

    Article  PubMed  PubMed Central  Google Scholar 

  205. Tran TB et al (2015) Locally advanced intrahepatic cholangiocarcinoma: complete pathologic response to neoadjuvant chemotherapy followed by left hepatic trisectionectomy and caudate lobectomy. Dig Dis Sci. doi:10.1007/s10620-015-3640-x

    Google Scholar 

  206. Walker EJ, Simko JP, Nakakura EK, Ko AH (2014) A patient with cholangiocarcinoma demonstrating pathologic complete response to chemotherapy: exploring the role of neoadjuvant therapy in biliary tract cancer. J Gastrointest Oncol 5:E88–E95

    PubMed  PubMed Central  Google Scholar 

  207. Glazer ES, Liu P, Abdalla EK, Vauthey J-N, Curley SA (2012) Neither neoadjuvant nor adjuvant therapy increases survival after biliary tract cancer resection with wide negative margins. J Gastrointest Surg Off J Soc Surg Aliment Tract 16:1666–1671

    Article  Google Scholar 

  208. Darwish Murad S et al (2012) Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers. Gastroenterology 143:88–98, e3; quiz e14

    Google Scholar 

  209. Arrington AK et al (2013) Impact of medical and surgical intervention on survival in patients with cholangiocarcinoma. World J Gastrointest Surg 5:178–186

    Article  PubMed  PubMed Central  Google Scholar 

  210. Bektas H et al (2015) Surgical treatment for intrahepatic cholangiocarcinoma in Europe: a single center experience. J Hepato-Biliary-Pancreat Sci 22:131–137

    Article  Google Scholar 

  211. Ebata T et al (2012) Hepatopancreatoduodenectomy for cholangiocarcinoma: a single-center review of 85 consecutive patients. Ann Surg 256:297–305

    Article  PubMed  Google Scholar 

  212. Furusawa N et al (2014) Surgical treatment of 144 cases of hilar cholangiocarcinoma without liver-related mortality. World J Surg 38:1164–1176

    Article  PubMed  Google Scholar 

  213. Boland B, Kim A, Nissen N, Colquhoun S (2012) Cholangiocarcinoma: aggressive surgical intervention remains justified. Am Surg 78:157–160

    PubMed  Google Scholar 

  214. Anderson JE, Hemming AW, Chang DC, Talamini MA, Mekeel KL (2012) Surgical management trends for cholangiocarcinoma in the USA 1998–2009. J Gastrointest Surg Off J Soc Surg Aliment Tract 16:2225–2232

    Article  Google Scholar 

  215. Ribero D et al (2012) Surgical approach for long-term survival of patients with intrahepatic cholangiocarcinoma: a multi-institutional analysis of 434 patients. Arch Surg Chic Ill 1960(147):1107–1113

    Article  Google Scholar 

  216. Zhang W, Yan L-N (2014) Perihilar cholangiocarcinoma: current therapy. World J Gastrointest Pathophysiol 5:344–354

    PubMed  PubMed Central  Google Scholar 

  217. Maithel SK et al (2013) Multidisciplinary approaches to intrahepatic cholangiocarcinoma. Cancer 119:3929–3942

    Article  PubMed  Google Scholar 

  218. DeOliveira ML, Kambakamba P, Clavien P-A (2013) Advances in liver surgery for cholangiocarcinoma. Curr Opin Gastroenterol 29:293–298

    PubMed  Google Scholar 

  219. Cho MS et al (2012) Surgical outcomes and predicting factors of curative resection in patients with hilar cholangiocarcinoma: 10-year single-institution experience. J Gastrointest Surg Off J Soc Surg Aliment Tract 16:1672–1679

    Article  Google Scholar 

  220. Ali SM, Clark CJ, Zaydfudim VM, Que FG, Nagorney DM (2013) Role of major vascular resection in patients with intrahepatic cholangiocarcinoma. Ann Surg Oncol 20:2023–2028

    Article  PubMed  Google Scholar 

  221. Bergeat D et al (2015) Extended liver resections for intrahepatic cholangiocarcinoma: friend or foe? Surgery 157:656–665

    Article  PubMed  Google Scholar 

  222. Neuhaus P et al (1999) Extended resections for hilar cholangiocarcinoma. Ann Surg 230:808–818; discussion 819

    Google Scholar 

  223. Regimbeau JM et al (2011) Surgery for hilar cholangiocarcinoma: a multi-institutional update on practice and outcome by the AFC-HC study group. J Gastrointest Surg Off J Soc Surg Aliment Tract 15:480–488

    Article  Google Scholar 

  224. Tan JW et al (2013) One-stage resection for Bismuth type IV hilar cholangiocarcinoma with high hilar resection and parenchyma-preserving strategies: a cohort study. World J Surg 37:614–621

    Article  PubMed  Google Scholar 

  225. Levy C et al (2005) The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis. Dig Sci 50:1734–1740

    Article  CAS  Google Scholar 

  226. Corvera CU, Weber SM, Jarnagin WR (2002) Role of laparoscopy in the evaluation of biliary tract cancer. Surg Oncol Clin N Am 11:877–891

    Article  PubMed  Google Scholar 

  227. Kitagawa Y et al (2001) Lymph node metastasis from hilar cholangiocarcinoma: audit of 110 patients who underwent regional and paraaortic node dissection. Ann Surg 233:385–392

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  228. Burke EC et al (1998) Hilar Cholangiocarcinoma: patterns of spread, the importance of hepatic resection for curative operation, and a presurgical clinical staging system. Ann Surg 228:385–394

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  229. Hadjis NS, Blenkharn JI, Alexander N, Benjamin IS, Blumgart LH (1990) Outcome of radical surgery in hilar cholangiocarcinoma. Surgery 107:597–604

    CAS  PubMed  Google Scholar 

  230. Nimura Y et al (1991) Combined portal vein and liver resection for carcinoma of the biliary tract. Br J Surg 78:727–731

    Article  CAS  PubMed  Google Scholar 

  231. Mizumoto R, Suzuki H (1988) Surgical anatomy of the hepatic hilum with special reference to the caudate lobe. World J Surg 12:2–10

    Article  CAS  PubMed  Google Scholar 

  232. Nimura Y, Hayakawa N, Kamiya J, Kondo S, Shionoya S (1990) Hepatic segmentectomy with caudate lobe resection for bile duct carcinoma of the hepatic hilus. World J Surg 14:535–543; discussion 544

    Google Scholar 

  233. Ogura Y, Mizumoto R, Tabata M, Matsuda S, Kusuda T (1993) Surgical treatment of carcinoma of the hepatic duct confluence: analysis of 55 resected carcinomas. World J Surg 17:85–92; discussion 92–93

    Google Scholar 

  234. Sugiura Y et al (1994) Extensive resection of the bile ducts combined with liver resection for cancer of the main hepatic duct junction: a cooperative study of the Keio Bile Duct Cancer Study Group. Surgery 115:445–451

    CAS  PubMed  Google Scholar 

  235. Gazzaniga GM, Filauro M, Bagarolo C, Mori L (2000) Surgery for hilar cholangiocarcinoma: an Italian experience. J Hepatobiliary Pancreat Surg 7:122–127

    Article  CAS  PubMed  Google Scholar 

  236. Higuchi R et al (2015) Improved surgical outcomes for hilar cholangiocarcinoma: changes in surgical procedures and related outcomes based on 40 years of experience at a single institution. Surg Today. doi:10.1007/s00595-015-1119-1

    Google Scholar 

  237. Abbas S, Sandroussi C (2013) Systematic review and meta-analysis of the role of vascular resection in the treatment of hilar cholangiocarcinoma. HPB 15:492–503

    Article  PubMed  PubMed Central  Google Scholar 

  238. Chen W, Ke K, Chen YL (2014) Combined portal vein resection in the treatment of hilar cholangiocarcinoma: a systematic review and meta-analysis. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol 40:489–495

    CAS  Google Scholar 

  239. Li T et al (2014) Staging, prognostic factors and adjuvant therapy of intrahepatic cholangiocarcinoma after curative resection. Liver Int Off J Int Assoc Study Liver 34:953–960

    Google Scholar 

  240. Takahashi Y et al (2015) Surgery for recurrent biliary tract cancer: a single-center experience with 74 consecutive resections. Ann Surg 262:121–129

    Article  PubMed  Google Scholar 

  241. Kwon HJ, Kim SG, Chun JM, Lee WK, Hwang YJ (2014) Prognostic factors in patients with middle and distal bile duct cancers. World J Gastroenterol WJG 20:6658–6665

    Article  PubMed  Google Scholar 

  242. Aoba T et al (2013) Assessment of nodal status for perihilar cholangiocarcinoma: location, number, or ratio of involved nodes. Ann Surg 257:718–725

    Article  PubMed  Google Scholar 

  243. Spolverato G et al (2015) Conditional probability of long-term survival after liver resection for intrahepatic cholangiocarcinoma: a multi-institutional analysis of 535 patients. JAMA Surg 150:538–545

    Article  PubMed  Google Scholar 

  244. Spolverato G et al (2015) The impact of surgical margin status on long-term outcome after resection for intrahepatic cholangiocarcinoma. Ann Surg Oncol. doi:10.1245/s10434-015-4472-9

    Google Scholar 

  245. Kim Y et al (2015) Surgical management of intrahepatic cholangiocarcinoma: defining an optimal prognostic lymph node stratification schema. Ann Surg Oncol 22:2772–2778

    Article  PubMed  Google Scholar 

  246. Oguro S et al (2015) Optimal indications for additional resection of the invasive cancer-positive proximal bile duct margin in cases of advanced perihilar cholangiocarcinoma. Ann Surg Oncol 22:1915–1924

    Article  PubMed  Google Scholar 

  247. Guglielmi A et al (2013) Patterns and prognostic significance of lymph node dissection for surgical treatment of perihilar and intrahepatic cholangiocarcinoma. J Gastrointest Surg Off J Soc Surg Aliment Tract 17:1917–1928

    Article  Google Scholar 

  248. Nakeeb A, Pitt HA (2005) Radiation therapy, chemotherapy and chemoradiation in hilar cholangiocarcinoma. HPB 7:278–282

    Article  PubMed  PubMed Central  Google Scholar 

  249. Anderson C, Kim R (2009) Adjuvant therapy for resected extrahepatic cholangiocarcinoma: a review of the literature and future directions. Cancer Treat Rev 35:322–327

    Article  PubMed  Google Scholar 

  250. Howell M, Valle JW (2015) The role of adjuvant chemotherapy and radiotherapy for cholangiocarcinoma. Best Pract Res Clin Gastroenterol 29:333–343

    Article  PubMed  Google Scholar 

  251. Horgan AM, Amir E, Walter T, Knox JJ (2012) Adjuvant therapy in the treatment of biliary tract cancer: a systematic review and meta-analysis. J Clin Oncol Off J Am Soc Clin Oncol 30:1934–1940

    Article  Google Scholar 

  252. McNamara MG et al (2015) Outcome of adjuvant therapy in biliary tract cancers. Am J Clin Oncol 38:382–387

    Article  CAS  PubMed  Google Scholar 

  253. Stein A et al (2015) Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial)—A randomized, multidisciplinary, multinational phase III trial. BMC Cancer 15:564

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  254. Takada T et al (2002) Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer 95:1685–1695

    Article  PubMed  Google Scholar 

  255. Wirasorn K et al (2013) Adjuvant chemotherapy in resectable cholangiocarcinoma patients. J Gastroenterol Hepatol 28:1885–1891

    Article  CAS  PubMed  Google Scholar 

  256. Murakami Y et al (2009) Gemcitabine-based adjuvant chemotherapy improves survival after aggressive surgery for hilar cholangiocarcinoma. J Gastrointest Surg Off J Soc Surg Aliment Tract 13:1470–1479

    Article  Google Scholar 

  257. Yamanaka K et al (2014) A single-center analysis of the survival benefits of adjuvant gemcitabine chemotherapy for biliary tract cancer. Int J Clin Oncol 19:485–489

    Article  CAS  PubMed  Google Scholar 

  258. Shinohara ET, Mitra N, Guo M, Metz JM (2009) Radiotherapy is associated with improved survival in adjuvant and palliative treatment of extrahepatic cholangiocarcinomas. Int J Radiat Oncol Biol Phys 74:1191–1198

    Article  PubMed  Google Scholar 

  259. Vern-Gross TZ et al (2011) Survival outcomes in resected extrahepatic cholangiocarcinoma: effect of adjuvant radiotherapy in a surveillance, epidemiology, and end results analysis. Int J Radiat Oncol Biol Phys 81:189–198

    Article  PubMed  Google Scholar 

  260. Bonet Beltrán M, Allal AS, Gich I, Solé JM, Carrió I (2012) Is adjuvant radiotherapy needed after curative resection of extrahepatic biliary tract cancers? A systematic review with a meta-analysis of observational studies. Cancer Treat Rev 38:111–119

    Article  PubMed  Google Scholar 

  261. Serafini FM et al (2001) Location, not staging, of cholangiocarcinoma determines the role for adjuvant chemoradiation therapy. Am Surg 67:839–843; discussion 843–844

    Google Scholar 

  262. Hoehn RS et al (2015) Adjuvant chemotherapy and radiation therapy is associated with improved survival for patients with extrahepatic cholangiocarcinoma. Ann Surg Oncol. doi:10.1245/s10434-015-4599-8

    Google Scholar 

  263. Hughes MA et al (2007) Adjuvant concurrent chemoradiation for adenocarcinoma of the distal common bile duct. Int J Radiat Oncol Biol Phys 68:178–182

    Article  CAS  PubMed  Google Scholar 

  264. Borghero Y et al (2008) Extrahepatic bile duct adenocarcinoma: patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone. Ann Surg Oncol 15:3147–3156

    Article  PubMed  Google Scholar 

  265. Goldstein RM et al (1993) Is liver transplantation indicated for cholangiocarcinoma? Am J Surg 166:768–771; discussion 771–772

    Google Scholar 

  266. Meyer CG, Penn I, James L (2000) Liver transplantation for cholangiocarcinoma: results in 207 patients. Transplantation 69:1633–1637

    Article  CAS  PubMed  Google Scholar 

  267. Sudan D et al (2002) Radiochemotherapy and transplantation allow long-term survival for nonresectable hilar cholangiocarcinoma. Am J Transplant Off J Am Soc Transplant Am Soc Transpl Surg 2:774–779

    Article  Google Scholar 

  268. Heimbach JK et al (2004) Liver transplantation for unresectable perihilar cholangiocarcinoma. Semin Liver Dis 24:201–207

    Article  PubMed  Google Scholar 

  269. Rea DJ et al (2005) Liver transplantation with neoadjuvant chemoradiation is more effective than resection for hilar cholangiocarcinoma. Ann Surg 242:451–458; discussion 458–461

    Google Scholar 

  270. Robles R, Sánchez-Bueno F, Ramírez P, Brusadin R, Parrilla P (2013) Liver transplantation for hilar cholangiocarcinoma. World J Gastroenterol WJG 19:9209–9215

    Article  PubMed  Google Scholar 

  271. Hong JC et al (2011) Comparative analysis of resection and liver transplantation for intrahepatic and hilar cholangiocarcinoma: a 24-year experience in a single center. Arch Surg Chic Ill 1960(146):683–689

    Article  Google Scholar 

  272. Gu J et al (2012) Efficacy and safety of liver transplantation in patients with cholangiocarcinoma: a systematic review and meta-analysis. Int J Cancer J Int Cancer 130:2155–2163

    Article  CAS  Google Scholar 

  273. Becker NS et al (2008) Outcomes analysis for 280 patients with cholangiocarcinoma treated with liver transplantation over an 18-year period. J Gastrointest Surg Off J Soc Surg Aliment Tract 12:117–122

    Article  Google Scholar 

  274. Croome KP, Rosen CB, Heimbach JK, Nagorney DM (2015) Is liver transplantation appropriate for patients with potentially resectable De Novo Hilar cholangiocarcinoma? J Am Coll Surg 221:130–139

    Article  PubMed  Google Scholar 

  275. Jarnagin WR et al (2001) Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg 234:507–517; discussion 517–519

    Google Scholar 

  276. Pichlmayr R et al (1996) Surgical treatment in proximal bile duct cancer. A single-center experience. Ann Surg 224:628–638

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  277. Farley DR, Weaver AL, Nagorney DM (1995) ‘Natural history’ of unresected cholangiocarcinoma: patient outcome after noncurative intervention. Mayo Clin Proc 70:425–429

    Article  CAS  PubMed  Google Scholar 

  278. Berr F (2004) Photodynamic therapy for cholangiocarcinoma. Semin Liver Dis 24:177–187

    Article  PubMed  Google Scholar 

  279. Chang WH, Kortan P, Haber GB (1998) Outcome in patients with bifurcation tumors who undergo unilateral versus bilateral hepatic duct drainage. Gastrointest Endosc 47:354–362

    Article  CAS  PubMed  Google Scholar 

  280. House MG, Choti MA (2004) Palliative therapy for pancreatic/biliary cancer. Surg Oncol Clin N Am 13:491–503, ix

    Google Scholar 

  281. Rerknimitr R, Kladcharoen N, Mahachai V, Kullavanijaya P (2004) Result of endoscopic biliary drainage in hilar cholangiocarcinoma. J Clin Gastroenterol 38:518–523

    Article  PubMed  Google Scholar 

  282. Prat F et al (1998) Predictive factors for survival of patients with inoperable malignant distal biliary strictures: a practical management guideline. Gut 42:76–80

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  283. Abu-Hamda EM, Baron TH (2004) Endoscopic management of cholangiocarcinoma. Semin Liver Dis 24:165–175

    Article  PubMed  Google Scholar 

  284. Cheung KL, Lai EC (1995) Endoscopic stenting for malignant biliary obstruction. Arch Surg 130:204–207

    Article  CAS  PubMed  Google Scholar 

  285. Schima W et al (1997) Biliary Wallstent endoprosthesis in malignant hilar obstruction: long-term results with regard to the type of obstruction. Clin Radiol 52:213–219

    Article  CAS  PubMed  Google Scholar 

  286. De Palma GD et al (2003) Unilateral placement of metallic stents for malignant hilar obstruction: a prospective study. Gastrointest Endosc 58:50–53

    Article  PubMed  Google Scholar 

  287. Freeman ML, Overby C (2003) Selective MRCP and CT-targeted drainage of malignant hilar biliary obstruction with self-expanding metallic stents. Gastrointest Endosc 58:41–49

    Article  PubMed  Google Scholar 

  288. Dowsett JF et al (1989) Endoscopic biliary therapy using the combined percutaneous and endoscopic technique. Gastroenterology 96:1180–1186

    Article  CAS  PubMed  Google Scholar 

  289. Kaassis M et al (2003) Plastic or metal stents for malignant stricture of the common bile duct? Results of a randomized prospective study. Gastrointest Endosc 57:178–182

    Article  PubMed  Google Scholar 

  290. Isayama H et al (2004) A prospective randomised study of ‘covered’ versus ‘uncovered’ diamond stents for the management of distal malignant biliary obstruction. Gut 53:729–734

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  291. Flickinger JC, Epstein AH, Iwatsuki S, Carr BI, Starzl TE (1991) Radiation therapy for primary carcinoma of the extrahepatic biliary system. An analysis of 63 cases. Cancer 68:289–294

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  292. Foo ML, Gunderson LL, Bender CE, Buskirk SJ (1997) External radiation therapy and transcatheter iridium in the treatment of extrahepatic bile duct carcinoma. Int J Radiat Oncol Biol Phys 39:929–935

    Article  CAS  PubMed  Google Scholar 

  293. Kuvshinoff BW et al (1995) Palliation of irresectable hilar cholangiocarcinoma with biliary drainage and radiotherapy. Br J Surg 82:1522–1525

    Article  CAS  PubMed  Google Scholar 

  294. Ghafoori AP et al (2011) Radiotherapy in the treatment of patients with unresectable extrahepatic cholangiocarcinoma. Int J Radiat Oncol Biol Phys 81:654–659

    Article  PubMed  Google Scholar 

  295. Chen Y-X et al (2010) Determining the role of external beam radiotherapy in unresectable intrahepatic cholangiocarcinoma: a retrospective analysis of 84 patients. BMC Cancer 10:492

    Article  PubMed  PubMed Central  Google Scholar 

  296. Crane CH et al (2002) Limitations of conventional doses of chemoradiation for unresectable biliary cancer. Int J Radiat Oncol Biol Phys 53:969–974

    Article  PubMed  Google Scholar 

  297. Valek V et al (2007) Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study. Eur J Radiol 62:175–179

    Article  PubMed  Google Scholar 

  298. Shin HS et al (2003) Combination of external beam irradiation and high-dose-rate intraluminal brachytherapy for inoperable carcinoma of the extrahepatic bile ducts. Int J Radiat Oncol Biol Phys 57:105–112

    Article  PubMed  Google Scholar 

  299. Isayama H et al (2012) Clinical benefit of radiation therapy and metallic stenting for unresectable hilar cholangiocarcinoma. World J Gastroenterol WJG 18:2364–2370

    Article  PubMed  Google Scholar 

  300. Barney BM, Olivier KR, Miller RC, Haddock MG (2012) Clinical outcomes and toxicity using stereotactic body radiotherapy (SBRT) for advanced cholangiocarcinoma. Radiat Oncol Lond Engl 7:67

    Article  Google Scholar 

  301. Mouli S et al (2013) Yttrium-90 radioembolization for intrahepatic cholangiocarcinoma: safety, response, and survival analysis. J Vasc Interv Radiol JVIR 24:1227–1234

    Article  PubMed  Google Scholar 

  302. Al-Adra DP et al (2015) Treatment of unresectable intrahepatic cholangiocarcinoma with yttrium-90 radioembolization: a systematic review and pooled analysis. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol 41:120–127

    CAS  Google Scholar 

  303. Jung DH et al (2014) Outcomes of stereotactic body radiotherapy for unresectable primary or recurrent cholangiocarcinoma. Radiat Oncol J 32:163–169

    Article  PubMed  PubMed Central  Google Scholar 

  304. Glimelius B et al (1996) Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Ann Oncol 7:593–600

    Article  CAS  PubMed  Google Scholar 

  305. Nehls O et al (2002) Oxaliplatin, fluorouracil and leucovorin for advanced biliary system adenocarcinomas: a prospective phase II trial. Br J Cancer 87:702–704

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  306. Rao S et al (2005) Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer. Br J Cancer 92:1650–1654

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  307. Nehls O et al (2008) Capecitabine plus oxaliplatin as first-line treatment in patients with advanced biliary system adenocarcinoma: a prospective multicentre phase II trial. Br J Cancer 98:309–315

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  308. Eckel F, Schmid RM (2007) Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials. Br J Cancer 96:896–902

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  309. Valle J et al (2010) Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med 362:1273–1281

    Article  CAS  PubMed  Google Scholar 

  310. Fiteni F et al (2014) Cisplatin/gemcitabine or oxaliplatin/gemcitabine in the treatment of advanced biliary tract cancer: a systematic review. Cancer Med 3:1502–1511

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  311. Fiteni F et al (2014) Advanced biliary tract carcinomas: a retrospective multicenter analysis of first and second-line chemotherapy. BMC Gastroenterol 14:143

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  312. Malka D et al (2014) Gemcitabine and oxaliplatin with or without cetuximab in advanced biliary-tract cancer (BINGO): a randomised, open-label, non-comparative phase 2 trial. Lancet Oncol 15:819–828

    Article  CAS  PubMed  Google Scholar 

  313. Liu H, Zhang Q-D, Li Z-H, Zhang Q-Q, Lu L-G (2014) Efficacy and safety of gemcitabine-based chemotherapies in biliary tract cancer: a meta-analysis. World J Gastroenterol WJG 20:18001–18012

    CAS  PubMed  Google Scholar 

  314. Ghosn M et al (2015) Optimum chemotherapy for the management of advanced biliary tract cancer. World J Gastroenterol WJG 21:4121–4125

    Article  CAS  PubMed  Google Scholar 

  315. Valle JW et al (2015) Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial. Lancet Oncol 16:967–978

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  316. Hezel AF et al (2014) Phase II study of gemcitabine, oxaliplatin in combination with panitumumab in KRAS wild-type unresectable or metastatic biliary tract and gallbladder cancer. Br J Cancer 111:430–436

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  317. Lamarca A, Hubner RA, David Ryder W, Valle JW (2014) Second-line chemotherapy in advanced biliary cancer: a systematic review. Ann Oncol Off J Eur Soc Med Oncol ESMO 25:2328–2338

    Article  CAS  Google Scholar 

  318. Polistina FA et al (2011) Chemoradiation treatment with gemcitabine plus stereotactic body radiotherapy for unresectable, non-metastatic, locally advanced hilar cholangiocarcinoma. Results of a five year experience. Radiother Oncol J Eur Soc Ther Radiol Oncol 99:120–123

    Article  CAS  Google Scholar 

  319. Leong E et al (2012) Outcomes from combined chemoradiotherapy in unresectable and locally advanced resected cholangiocarcinoma. J Gastrointest Cancer 43:50–55

    Article  CAS  PubMed  Google Scholar 

  320. Phelip J-M et al (2014) Gemcitabine plus cisplatin versus chemoradiotherapy in locally advanced biliary tract cancer: Fédération Francophone de Cancérologie Digestive 9902 phase II randomised study. Eur J Cancer Oxf Engl 1990(50):2975–2982

    Article  CAS  Google Scholar 

  321. Zechlinski JJ, Rilling WS (2013) Transarterial therapies for the treatment of intrahepatic cholangiocarcinoma. Semin Interv Radiol 30:21–27

    Article  Google Scholar 

  322. Kuhlmann JB, Blum HE (2013) Locoregional therapy for cholangiocarcinoma. Curr Opin Gastroenterol 29:324–328

    Article  PubMed  Google Scholar 

  323. Ray CE et al (2013) Metaanalysis of survival, complications, and imaging response following chemotherapy-based transarterial therapy in patients with unresectable intrahepatic cholangiocarcinoma. J Vasc Interv Radiol JVIR 24:1218–1226

    Article  PubMed  Google Scholar 

  324. Burger I et al (2005) Transcatheter arterial chemoembolization in unresectable cholangiocarcinoma: initial experience in a single institution. J Vasc Interv Radiol JVIR 16:353–361

    Article  PubMed  Google Scholar 

  325. Park S-Y et al (2011) Transarterial chemoembolization versus supportive therapy in the palliative treatment of unresectable intrahepatic cholangiocarcinoma. Clin Radiol 66:322–328

    Article  PubMed  Google Scholar 

  326. Hyder O et al (2013) Intra-arterial therapy for advanced intrahepatic cholangiocarcinoma: a multi-institutional analysis. Ann Surg Oncol 20:3779–3786

    Article  PubMed  Google Scholar 

  327. Vogl TJ et al (2012) Transarterial chemoembolization in the treatment of patients with unresectable cholangiocarcinoma: Results and prognostic factors governing treatment success. Int J Cancer J Int Cancer 131:733–740

    Article  CAS  Google Scholar 

  328. Kim JH et al (2008) Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma: clinical efficacy and factors influencing outcomes. Cancer 113:1614–1622

    Article  PubMed  Google Scholar 

  329. Ortner MA (2004) Photodynamic therapy in cholangiocarcinomas. Best Pr Res Clin Gastroenterol 18:147–154

    Article  Google Scholar 

  330. Ortner ME et al (2003) Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study. Gastroenterology 125:1355–1363

    Article  PubMed  Google Scholar 

  331. Lee TY, Cheon YK, Shim CS, Cho YD (2012) Photodynamic therapy prolongs metal stent patency in patients with unresectable hilar cholangiocarcinoma. World J Gastroenterol WJG 18:5589–5594

    Article  CAS  PubMed  Google Scholar 

  332. Höblinger A et al (2011) Feasibility and safety of long-term photodynamic therapy (PDT) in the palliative treatment of patients with hilar cholangiocarcinoma. Eur J Med Res 16:391–395

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

The authors would like to thank Stacy Miers for her expert administrative support and Jennifer Schnellmann, Ph.D., ELS for her expert editorial assistance.

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Ho, J., Curley, S.A. (2016). Diagnosis and Management of Intrahepatic and Extrahepatic Cholangiocarcinoma. In: Bentrem, D., Benson, A. (eds) Gastrointestinal Malignancies. Cancer Treatment and Research. Springer, Cham. https://doi.org/10.1007/978-3-319-34244-3_7

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