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Circulating Tumor Cells in Gastrointestinal Cancer: Current Practices and Future Directions

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Gastrointestinal Malignancies

Part of the book series: Cancer Treatment and Research ((CTAR))

Abstract

GI cancers are the leading cause of cancer-related death worldwide primarily due to a combination of late presentation and aggressive biology. The lack of adequate biomarkers for screening, diagnosis, staging, and prognosis confounds clinical decision-making and delays potentially effective therapies. Circulating tumor cells (CTCs) are a new biomarker with particular promise in GI cancers, potentially offering clinicians and researchers real-time access to tumor tissue in a reliable, safe, and cost-effective manner. Preliminary studies have investigated the potential clinical utility of CTCs for all GI cancer types with promising results. Furthermore, advances in single cell analytics have been successfully applied to CTCs, allowing for exciting new clinical and research applications. In this chapter, we will review the current state of CTC research in GI cancers as well as the potential future applications that are currently being developed.

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  1. Department of Surgery, University of California Los Angeles, Los Angeles, USA

    Colin M. Court, Jacob S. Ankeny, Shonan Sho & James S. Tomlinson

  2. Department of Surgery, Greater Los Angeles VA, Los Angeles, USA

    Colin M. Court, Jacob S. Ankeny, Shonan Sho & James S. Tomlinson

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  1. Department of Surgery, Northwestern University, Chicago, Illinois, USA

    David Bentrem

  2. Robert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois, USA

    Al B. Benson

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Court, C.M., Ankeny, J.S., Sho, S., Tomlinson, J.S. (2016). Circulating Tumor Cells in Gastrointestinal Cancer: Current Practices and Future Directions. In: Bentrem, D., Benson, A. (eds) Gastrointestinal Malignancies. Cancer Treatment and Research. Springer, Cham. https://doi.org/10.1007/978-3-319-34244-3_17

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