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Osteoimmunological Aspects of Biomechanics

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Principles of Osteoimmunology

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Abstract

Different endogenous and exogenous factors which interfere with bone health have been identified. Among these, physical activity that relates to regular intermittent mechanical bone loading seems to be one of the major factors controlling bone mass and the prevention of osteoporotic fractures. Moreover, an interaction between bone homeostasis and the immune system which may be modified by regular physical activity exists. Bone and immune cells share a common site of origin, the bone marrow. They are supposed to influence each other not only during maturation; osteoclasts and immune cells have a number of regulatory molecules in common including cytokines, receptors, signalling molecules, and transcription factors, which influence each other.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria

    Katharina Kerschan-Schindl MD & Gerold Ebenbichler MD

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  1. Katharina Kerschan-Schindl MD
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  2. Gerold Ebenbichler MD
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Correspondence to Katharina Kerschan-Schindl MD .

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  1. Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria

    Peter Pietschmann

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Kerschan-Schindl, K., Ebenbichler, G. (2016). Osteoimmunological Aspects of Biomechanics. In: Pietschmann, P. (eds) Principles of Osteoimmunology. Springer, Cham. https://doi.org/10.1007/978-3-319-34238-2_5

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