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Molecular Mechanisms of Hepatocellular Carcinoma

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Hepatocellular Carcinoma

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Hepatocellular carcinoma is a highly heterogeneous disease for different reasons. First, there are multiple and highly variable etiological factors including viruses with a DNA (HBV) or RNA (HCV) genome, chemicals (alcohol and aflatoxins), and inborn and acquired metabolic diseases. Second, these cancers might originate either from mature hepatocytes or from progenitor cells. Third, like other cancers, HCC undergoes a dynamic process changing morphology and molecular features as it advances. Therefore, molecular mechanisms of hepatocellular carcinogenesis may vary depending on different factors and this is probably why a large set of mechanisms have been associated with these tumors. Among many different mechanisms described, we review here those that we believe are the most prominent ones including loss of cell cycle control, escape from senescence control, resistance to cell death, phenotypic plasticity, motility, invasion, and metastasis.

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Authors and Affiliations

  1. Izmir International Biomedicine and Genome Institute, Dokuz Eylül University, Balcova, Izmir, Turkey

    Hani Alotaibi, Nese Atabey, Kasım Diril, Esra Erdal & Mehmet Ozturk

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  1. Hani Alotaibi
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  2. Nese Atabey
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  3. Kasım Diril
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Correspondence to Mehmet Ozturk .

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  1. Dokuz Eylul University, Izmir Biomedicine and Genome Center Dokuz Eylul University, Izmir, Izmir, Turkey

    Brian I. Carr

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Alotaibi, H., Atabey, N., Diril, K., Erdal, E., Ozturk, M. (2016). Molecular Mechanisms of Hepatocellular Carcinoma. In: Carr, B. (eds) Hepatocellular Carcinoma. Current Clinical Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-34214-6_3

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