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Interventional Therapies for Secondary and Essential Hypertension pp 193–200Cite as

Pathophysiology of Renal Sympathetic Denervation (RSDN)

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Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

Abstract

Activation of the sympathetic nervous system (SNS) has been identified as a key pathophysiological feature involved in the initiation, progression but also prognosis of most cardiometabolic disorders (chronic heart failure or kidney disease, coronary heart disease, obesity, diabetes, etc.), among them hypertension (HTN). This has been established through studies recording SNS activation at systemic and local levels using different techniques to measure SNS outflow to various organs. Mechanisms leading to SNS activation are heterogeneous varying from central activation to reflex-mediated sympathoexcitation (or lack of sympathoinhibition).

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Abbreviations

BP:

Blood pressure

CGRP:

Calcitonin gene-related peptide

CHF:

Congestive heart failure

GFR:

Glomerular filtration rate

HR:

Heart rate

HTN:

Hypertension

JGC:

Juxtaglomerular granular cells

MSNA:

Muscle sympathetic nerve activity

NOx:

Nitrogen oxide

RBF:

Renal blood flow

RDN:

Renal denervation

SHR:

Spontaneously hypertensive rats

SNA:

Sympathetic nerve activity

SNS:

Sympathetic nervous system

SP:

Surfactant protein

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Author information

Authors and Affiliations

  1. Department of Cardiovascular Medicine, Hypertension, Risk Factors and Heart Failure Unit, Clinique Pasteur, Avenue de Lombez, 31000, Toulouse, France

    Atul Pathak MD, Phd & Benjamin Honton MD

  2. William Harvey Research Institute, Barts NIHR Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK

    Mel Lobo MD

Authors
  1. Atul Pathak MD, Phd
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  2. Benjamin Honton MD
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  3. Mel Lobo MD
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Corresponding author

Correspondence to Atul Pathak MD, Phd .

Editor information

Editors and Affiliations

  1. First Cardiology Clinic, National and Kapodistrian University of Athens, Athens, Greece

    Costas Tsioufis

  2. Department of Nephrology and Hypertension, University Hospital Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

    Roland E. Schmieder

  3. IRCCS Istituto Auxologico Italiano, University Milano-Bicocca, Milano Monza, Italy

    Giuseppe Mancia

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© 2016 Springer International Publishing Switzerland

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Pathak, A., Honton, B., Lobo, M. (2016). Pathophysiology of Renal Sympathetic Denervation (RSDN). In: Tsioufis, C., Schmieder, R., Mancia, G. (eds) Interventional Therapies for Secondary and Essential Hypertension. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-34141-5_12

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  • DOI: https://doi.org/10.1007/978-3-319-34141-5_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-34140-8

  • Online ISBN: 978-3-319-34141-5

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