Skip to main content

Nausea and Vomiting Related to Non-esophageal and Non-Gastric Diseases of the Gastrointestinal Tract

  • Chapter
  • First Online:
Nausea and Vomiting
  • 1727 Accesses

Abstract

Nausea and vomiting related to non-esophageal and gastric diseases of the gastrointestinal tract has a broad differential diagnosis. This can include infectious causes, mechanical obstruction of the small or large intestine, organic gastrointestinal diseases, such as acute pancreatitis, or systemic disorders, including systemic lupus erythematosus and systemic scleroderma. Motility disorders, including enteric dysmotility and chronic intestinal pseudo-obstruction, as well as functional GI disorders, such as irritable bowel syndrome, may also commonly present with nausea and vomiting. This chapter will focus on the different causes of nausea and vomiting, their underlying pathogenesis, clinical presentation, and diagnostic possibilities. As nausea and vomiting are commonly encountered in clinical practice, the reader will hopefully gain a framework to conceptualize and organize all of the diagnostic possibilities in the gastrointestinal tract outside of the esophagus and stomach that may lead to these symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Keyssler JG, Pre-1801 Imprint Collection (Library of Congress). Travels through Germany, Bohemia, Hungary, Switzerland, Italy, and Lorrain. Giving a true and just description of the present state of those countries. 3rd ed. London: Printed for G. Keith etc; 1760.

    Google Scholar 

  2. Huxley A. Antic hay. New York: George H. Doran Company; 1923.

    Google Scholar 

  3. Camilleri M, et al. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin Gastroenterol Hepatol. 2005;3(6):543–52.

    Article  PubMed  Google Scholar 

  4. Blum RH, Heinrichs WL, Herxheimer A. Nausea and vomiting: overview, challenges, practical treatments and new perspectives. London and Philadelphia: Whurr Publishers 2000.

    Google Scholar 

  5. Garthright WE, Archer DL, Kvenberg JE. Estimates of incidence and costs of intestinal infectious diseases in the United States. Public Health Rep. 1988;103(2):107–15.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Scallan E, et al. Foodborne illness acquired in the United States--unspecified agents. Emerg Infect Dis. 2011;17(1):16–22.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Roy SL, Scallan E, Beach MJ. The rate of acute gastrointestinal illness in developed countries. J Water Health. 2006;4 Suppl 2:31–69.

    Article  PubMed  Google Scholar 

  8. Herikstad H, et al. A population-based estimate of the burden of diarrhoeal illness in the United States: FoodNet, 1996–7. Epidemiol Infect. 2002;129(1):9–17.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Imhoff B, et al. Burden of self-reported acute diarrheal illness in FoodNet surveillance areas, 1998–1999. Clin Infect Dis. 2004;38 Suppl 3:S219–26.

    Article  PubMed  Google Scholar 

  10. DuPont HL. Acute infectious diarrhea in immunocompetent adults. N Engl J Med. 2014;370(16):1532–40.

    Article  CAS  PubMed  Google Scholar 

  11. Bates PR, et al. Comparative epidemiology of rotavirus, subgenus F (types 40 and 41) adenovirus and astrovirus gastroenteritis in children. J Med Virol. 1993;39(3):224–8.

    Article  CAS  PubMed  Google Scholar 

  12. Bresee JS, et al. The etiology of severe acute gastroenteritis among adults visiting emergency departments in the United States. J Infect Dis. 2012;205(9):1374–81.

    Article  PubMed  Google Scholar 

  13. Guerrant RL, et al. Practice guidelines for the management of infectious diarrhea. Clin Infect Dis. 2001;32(3):331–51.

    Article  CAS  PubMed  Google Scholar 

  14. Dryden MS, Gabb RJ, Wright SK. Empirical treatment of severe acute community-acquired gastroenteritis with ciprofloxacin. Clin Infect Dis. 1996;22(6):1019–25.

    Article  CAS  PubMed  Google Scholar 

  15. Crim SM, et al. Incidence and trends of infection with pathogens transmitted commonly through food--foodborne diseases active surveillance network, 10 U.S. Sites, 2006–2013. MMWR Morb Mortal Wkly Rep. 2014;63(15):328–32.

    PubMed  Google Scholar 

  16. Irvin TT. Abdominal pain: a surgical audit of 1190 emergency admissions. Br J Surg. 1989;76(11):1121–5.

    Article  CAS  PubMed  Google Scholar 

  17. Wright HK, O’Brien JJ, Tilson MD. Water absorption in experimental closed segment obstruction of the ileum in man. Am J Surg. 1971;121(1):96–9.

    Article  CAS  PubMed  Google Scholar 

  18. Paulson EK, Thompson WM. Review of small-bowel obstruction: the diagnosis and when to worry. Radiology. 2015;275(2):332–42.

    Article  PubMed  Google Scholar 

  19. Drozdz W, Budzynski P. Change in mechanical bowel obstruction demographic and etiological patterns during the past century: observations from one health care institution. Arch Surg. 2012;147(2):175–80.

    Article  PubMed  Google Scholar 

  20. ten Broek RP, et al. Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis. BMJ. 2013;347:f5588.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Matter I, et al. Does the index operation influence the course and outcome of adhesive intestinal obstruction? Eur J Surg. 1997;163(10):767–72.

    CAS  PubMed  Google Scholar 

  22. Parker MC, et al. Colorectal surgery: the risk and burden of adhesion-related complications. Colorectal Dis. 2004;6(6):506–11.

    Article  CAS  PubMed  Google Scholar 

  23. Markogiannakis H, et al. Acute mechanical bowel obstruction: clinical presentation, etiology, management and outcome. World J Gastroenterol. 2007;13(3):432–7.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Whitcomb DC. Clinical practice. Acute pancreatitis. N Engl J Med. 2006;354(20):2142–50.

    Article  PubMed  Google Scholar 

  25. Whitcomb DC. Early trypsinogen activation in acute pancreatitis. Gastroenterology. 1999;116(3):770–2.

    Article  CAS  Google Scholar 

  26. Chwistek M, Roberts I, Amoateng-Adjepong Y. Gallstone pancreatitis: a community teaching hospital experience. J Clin Gastroenterol. 2001;33(1):41–4.

    Article  CAS  PubMed  Google Scholar 

  27. Lin Y, et al. Associations of alcohol drinking and nutrient intake with chronic pancreatitis: findings from a case–control study in Japan. Am J Gastroenterol. 2001;96(9):2622–7.

    Article  CAS  PubMed  Google Scholar 

  28. Cappell MS. Acute pancreatitis: etiology, clinical presentation, diagnosis, and therapy. Med Clin North Am. 2008;92(4):889–923, ix–x.

    Article  CAS  PubMed  Google Scholar 

  29. Schoots IG, et al. Systematic review of survival after acute mesenteric ischaemia according to disease aetiology. Br J Surg. 2004;91(1):17–27.

    Article  CAS  PubMed  Google Scholar 

  30. Acosta S, et al. Incidence of acute thrombo-embolic occlusion of the superior mesenteric artery–a population-based study. Eur J Vasc Endovasc Surg. 2004;27(2):145–50.

    Google Scholar 

  31. Herbert GS, Steele SR. Acute and chronic mesenteric ischemia. Surg Clin North Am. 2007;87(5):1115–34, ix.

    Article  PubMed  Google Scholar 

  32. Batellier J, Kieny R. Superior mesenteric artery embolism: eighty-two cases. Ann Vasc Surg. 1990;4(2):112–6.

    Article  CAS  PubMed  Google Scholar 

  33. Kazmers A. Operative management of chronic mesenteric ischemia. Ann Vasc Surg. 1998;12(3):299–308.

    Article  CAS  PubMed  Google Scholar 

  34. Zhang J, et al. Acute mesenteric venous thrombosis: a better outcome achieved through improved imaging techniques and a changed policy of clinical management. Eur J Vasc Endovasc Surg. 2004;28(3):329–34.

    Article  CAS  PubMed  Google Scholar 

  35. Hedayati N, et al. Prognostic factors and treatment outcome in mesenteric vein thrombosis. Vasc Endovascular Surg. 2008;42(3):217–24.

    Article  PubMed  Google Scholar 

  36. Acosta S, et al. Epidemiology, risk and prognostic factors in mesenteric venous thrombosis. Br J Surg. 2008;95(10):1245–51.

    Article  CAS  PubMed  Google Scholar 

  37. Martinez JP, Hogan GJ. Mesenteric ischemia. Emerg Med Clin North Am. 2004;22(4):909–28.

    Article  PubMed  Google Scholar 

  38. McCarthy E, et al. Radiology and mesenteric ischaemia. Clin Radiol. 2015;70(7):698–705.

    Article  CAS  PubMed  Google Scholar 

  39. Meyer T, et al. How can the prognosis of acute mesenteric artery ischemia be improved? Results of a retrospective analysis. Zentralbl Chir. 1998;123(3):230–4.

    CAS  PubMed  Google Scholar 

  40. Lange H, Jackel R. Usefulness of plasma lactate concentration in the diagnosis of acute abdominal disease. Eur J Surg. 1994;160(6–7):381–4.

    CAS  PubMed  Google Scholar 

  41. Lange H, Toivola A. Warning signals in acute abdominal disorders. Lactate is the best marker of mesenteric ischemia. Lakartidningen. 1997;94(20):1893–6.

    CAS  PubMed  Google Scholar 

  42. Acosta S. Epidemiology of mesenteric vascular disease: clinical implications. Semin Vasc Surg. 2010;23(1):4–8.

    Article  PubMed  Google Scholar 

  43. Poole JW, Sammartano RJ, Boley SJ. Hemodynamic basis of the pain of chronic mesenteric ischemia. Am J Surg. 1987;153(2):171–6.

    Article  CAS  PubMed  Google Scholar 

  44. Veenstra RP, et al. The cardiovascular risk profile of atherosclerotic gastrointestinal ischemia is different from other vascular beds. Am J Med. 2012;125(4):394–8.

    Article  PubMed  Google Scholar 

  45. Harward TR, Smith S, Seeger JM. Detection of celiac axis and superior mesenteric artery occlusive disease with use of abdominal duplex scanning. J Vasc Surg. 1993;17(4):738–45.

    Article  CAS  PubMed  Google Scholar 

  46. Moneta GL, et al. Mesenteric duplex scanning: a blinded prospective study. J Vasc Surg. 1993;17(1):79–84; discussion 85–6.

    Article  CAS  PubMed  Google Scholar 

  47. Gentile AT, et al. Usefulness of fasting and postprandial duplex ultrasound examinations for predicting high-grade superior mesenteric artery stenosis. Am J Surg. 1995;169(5):476–9.

    Article  CAS  PubMed  Google Scholar 

  48. Nicoloff AD, et al. Duplex ultrasonography in evaluation of splanchnic artery stenosis. Surg Clin North Am. 1997;77(2):339–55.

    Article  CAS  PubMed  Google Scholar 

  49. Chng HH, et al. Major gastrointestinal manifestations in lupus patients in Asia: lupus enteritis, intestinal pseudo-obstruction, and protein-losing gastroenteropathy. Lupus. 2010;19(12):1404–13.

    Article  CAS  PubMed  Google Scholar 

  50. Dubois EL, Tuffanelli DL. Clinical Manifestations of Systemic Lupus Erythematosus. Computer Analysis of 520 Cases. JAMA. 1964;190:104–11.

    Article  CAS  PubMed  Google Scholar 

  51. Helliwell TR, et al. Arteritis and venulitis in systemic lupus erythematosus resulting in massive lower intestinal haemorrhage. Histopathology. 1985;9(10):1103–13.

    Article  CAS  PubMed  Google Scholar 

  52. Sultan SM, Ioannou Y, Isenberg DA. A review of gastrointestinal manifestations of systemic lupus erythematosus. Rheumatology (Oxford). 1999;38(10):917–32.

    Article  CAS  Google Scholar 

  53. Schmeiser T, et al. Profile of gastrointestinal involvement in patients with systemic sclerosis. Rheumatol Int. 2012;32(8):2471–8.

    Article  CAS  PubMed  Google Scholar 

  54. Sallam H, McNearney TA, Chen JD. Systematic review: pathophysiology and management of gastrointestinal dysmotility in systemic sclerosis (scleroderma). Aliment Pharmacol Ther. 2006;23(6):691–712.

    Article  CAS  PubMed  Google Scholar 

  55. Fynne L, et al. Gastrointestinal transit in patients with systemic sclerosis. Scand J Gastroenterol. 2011;46(10):1187–93.

    Article  CAS  PubMed  Google Scholar 

  56. Marie I, et al. Manometry of the upper intestinal tract in patients with systemic sclerosis: a prospective study. Arthritis Rheum. 1998;41(10):1874–83.

    Article  CAS  PubMed  Google Scholar 

  57. Szamosi S, Szekanecz Z, Szucs G. Gastrointestinal manifestations in Hungarian scleroderma patients. Rheumatol Int. 2006;26(12):1120–4.

    Article  PubMed  Google Scholar 

  58. Drossman DA. Rome III: the functional gastrointestinal disorders. 3rd ed. McLean: Degnon Associates; 2006. p. 1048. xli.

    Google Scholar 

  59. Lindberg G, et al. Full-thickness biopsy findings in chronic intestinal pseudo-obstruction and enteric dysmotility. Gut. 2009;58(8):1084–90.

    Article  CAS  PubMed  Google Scholar 

  60. Stanghellini V, Camilleri M, Malagelada JR. Chronic idiopathic intestinal pseudo-obstruction: clinical and intestinal manometric findings. Gut. 1987;28(1):5–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Knowles CH, et al. New perspectives in the diagnosis and management of enteric neuropathies. Nat Rev Gastroenterol Hepatol. 2013;10(4):206–18.

    Article  CAS  PubMed  Google Scholar 

  62. Sodhi N, et al. Autonomic function and motility in intestinal pseudoobstruction caused by paraneoplastic syndrome. Dig Dis Sci. 1989;34(12):1937–42.

    Article  CAS  PubMed  Google Scholar 

  63. Gerl A, et al. Paraneoplastic chronic intestinal pseudoobstruction as a rare complication of bronchial carcinoid. Gut. 1992;33(7):1000–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Pande R, Leis AA. Myasthenia gravis, thymoma, intestinal pseudo-obstruction, and neuronal nicotinic acetylcholine receptor antibody. Muscle Nerve. 1999;22(11):1600–2.

    Article  CAS  PubMed  Google Scholar 

  65. Martin A, et al. A case of paraneoplastic inflammatory neuropathy of the gastrointestinal tract related to an underlying neuroblastoma: successful management with immunosuppressive therapy. J Pediatr Gastroenterol Nutr. 2008;46(4):457–60.

    Article  PubMed  Google Scholar 

  66. Lee HR, et al. Paraneoplastic gastrointestinal motor dysfunction: clinical and laboratory characteristics. Am J Gastroenterol. 2001;96(2):373–9.

    Article  CAS  PubMed  Google Scholar 

  67. Lennon VA, et al. Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma. Gastroenterology. 1991;100(1):137–42.

    Article  CAS  PubMed  Google Scholar 

  68. Lucchinetti CF, Kimmel DW, Lennon VA. Paraneoplastic and oncologic profiles of patients seropositive for type 1 antineuronal nuclear autoantibodies. Neurology. 1998;50(3):652–7.

    Article  CAS  PubMed  Google Scholar 

  69. Waterman SA. Autonomic dysfunction in Lambert-Eaton myasthenic syndrome. Clin Auton Res. 2001;11(3):145–54.

    Article  CAS  PubMed  Google Scholar 

  70. De Giorgio R, Camilleri M. Human enteric neuropathies: morphology and molecular pathology. Neurogastroenterol Motil. 2004;16(5):515–31.

    Article  PubMed  Google Scholar 

  71. Ferrante M, et al. The value of myenteric plexitis to predict early postoperative Crohn’s disease recurrence. Gastroenterology. 2006;130(6):1595–606.

    Article  PubMed  Google Scholar 

  72. Tornblom H, et al. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology. 2002;123(6):1972–9.

    Article  PubMed  Google Scholar 

  73. De Giorgio R, et al. Inflammatory neuropathies of the enteric nervous system. Gastroenterology. 2004;126(7):1872–83.

    Article  PubMed  Google Scholar 

  74. Bytzer P, et al. Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults. Arch Intern Med. 2001;161(16):1989–96.

    Article  CAS  PubMed  Google Scholar 

  75. Takahashi T, et al. Impaired expression of nitric oxide synthase in the gastric myenteric plexus of spontaneously diabetic rats. Gastroenterology. 1997;113(5):1535–44.

    Article  CAS  PubMed  Google Scholar 

  76. Wrzos HF, et al. Nitric oxide synthase (NOS) expression in the myenteric plexus of streptozotocin-diabetic rats. Dig Dis Sci. 1997;42(10):2106–10.

    Article  CAS  PubMed  Google Scholar 

  77. Chandrasekharan B, Srinivasan S. Diabetes and the enteric nervous system. Neurogastroenterol Motil. 2007;19(12):951–60.

    CAS  PubMed  PubMed Central  Google Scholar 

  78. Grover M, et al. Cellular changes in diabetic and idiopathic gastroparesis. Gastroenterology. 2011;140(5):1575–85.e8.

    Article  CAS  PubMed  Google Scholar 

  79. Ordog T. Interstitial cells of Cajal in diabetic gastroenteropathy. Neurogastroenterol Motil. 2008;20(1):8–18.

    Article  CAS  PubMed  Google Scholar 

  80. Ward SM, et al. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci. 2000;20(4):1393–403.

    CAS  PubMed  Google Scholar 

  81. Pfeiffer RF. Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol. 2003;2(2):107–16.

    Article  PubMed  Google Scholar 

  82. Edwards LL, et al. Gastrointestinal symptoms in Parkinson’s disease. Mov Disord. 1991;6(2):151–6.

    Article  CAS  PubMed  Google Scholar 

  83. Beach TG, et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol. 2010;119(6):689–702.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Lebouvier T, et al. Colonic biopsies to assess the neuropathology of Parkinson’s disease and its relationship with symptoms. PLoS One. 2010;5(9), e12728.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  85. Ebert EC, Nagar M. Gastrointestinal manifestations of amyloidosis. Am J Gastroenterol. 2008;103(3):776–87.

    Article  PubMed  Google Scholar 

  86. Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. N Engl J Med. 1997;337(13):898–909.

    Article  CAS  PubMed  Google Scholar 

  87. Briggs GW. Amyloidosis. Ann Intern Med. 1961;55:943–57.

    Article  CAS  PubMed  Google Scholar 

  88. Koppelman RN, et al. Acute small bowel pseudo-obstruction due to AL amyloidosis: a case report and literature review. Am J Gastroenterol. 2000;95(1):294–6.

    Article  CAS  PubMed  Google Scholar 

  89. Tada S, et al. Intestinal pseudo-obstruction in patients with amyloidosis: clinicopathologic differences between chemical types of amyloid protein. Gut. 1993;34(10):1412–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Sjogren RW. Gastrointestinal motility disorders in scleroderma. Arthritis Rheum. 1994;37(9):1265–82.

    Article  CAS  PubMed  Google Scholar 

  91. Mecoli C, et al. Mortality, recurrence, and hospital course of patients with systemic sclerosis-related acute intestinal pseudo-obstruction. J Rheumatol. 2014;41(10):2049–54.

    Article  PubMed  Google Scholar 

  92. Marie I, et al. Outcome of small-bowel motor impairment in systemic sclerosis--a prospective manometric 5-yr follow-up. Rheumatology (Oxford). 2007;46(1):150–3.

    Article  CAS  Google Scholar 

  93. Dudley HA, et al. Intestinal pseudo-obstruction. J R Coll Surg Edinb. 1958;3(3):206–17.

    CAS  PubMed  Google Scholar 

  94. Patcharatrakul T, Gonlachanvit S. Technique of functional and motility test: how to perform antroduodenal manometry. J Neurogastroenterol Motil. 2013;19(3):395–404.

    Article  PubMed  PubMed Central  Google Scholar 

  95. De Giorgio R, et al. Advances in our understanding of the pathology of chronic intestinal pseudo-obstruction. Gut. 2004;53(11):1549–52.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Stanghellini V, et al. Natural history of chronic idiopathic intestinal pseudo-obstruction in adults: a single center study. Clin Gastroenterol Hepatol. 2005;3(5):449–58.

    Article  PubMed  Google Scholar 

  97. Knowles CH, et al. Deranged smooth muscle alpha-actin as a biomarker of intestinal pseudo-obstruction: a controlled multinational case series. Gut. 2004;53(11):1583–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Locke 3rd GR. The epidemiology of functional gastrointestinal disorders in North America. Gastroenterol Clin North Am. 1996;25(1):1–19.

    Article  PubMed  Google Scholar 

  99. Lovell RM, Ford AC. Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin Gastroenterol Hepatol. 2012;10(7):712–21.e4.

    Article  PubMed  Google Scholar 

  100. Agreus L, et al. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology. 1995;109(3):671–80.

    Article  CAS  PubMed  Google Scholar 

  101. Talley NJ, Boyce P, Jones M. Identification of distinct upper and lower gastrointestinal symptom groupings in an urban population. Gut. 1998;42(5):690–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Su YC, et al. The association between Helicobacter pylori infection and functional dyspepsia in patients with irritable bowel syndrome. Am J Gastroenterol. 2000;95(8):1900–5.

    Article  CAS  PubMed  Google Scholar 

  103. Anbardan SJ, et al. Gender role in irritable bowel syndrome: a comparison of irritable bowel syndrome module (ROME III) between male and female patients. J Neurogastroenterol Motil. 2012;18(1):70–7.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Drossman DA, et al. AGA technical review on irritable bowel syndrome. Gastroenterology. 2002;123(6):2108–31.

    Article  PubMed  Google Scholar 

  105. Camilleri M, et al. Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2008;6(7):772–81.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Tornblom H, et al. Colonic transit time and IBS symptoms: what’s the link? Am J Gastroenterol. 2012;107(5):754–60.

    Article  PubMed  Google Scholar 

  107. Chey WY, et al. Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea. Am J Gastroenterol. 2001;96(5):1499–506.

    Article  CAS  PubMed  Google Scholar 

  108. Camilleri M, Coulie B, Tack JF. Visceral hypersensitivity: facts, speculations, and challenges. Gut. 2001;48(1):125–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Mawe GM, Hoffman JM. Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets. Nat Rev Gastroenterol Hepatol. 2013;10(8):473–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Camilleri M. Pharmacology of the new treatments for lower gastrointestinal motility disorders and irritable bowel syndrome. Clin Pharmacol Ther. 2012;91(1):44–59.

    Article  CAS  PubMed  Google Scholar 

  111. Simren M, et al. Intestinal microbiota in functional bowel disorders: a Rome foundation report. Gut. 2013;62(1):159–76.

    Article  PubMed  Google Scholar 

  112. Bertiaux-Vandaele N, et al. The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype. Am J Gastroenterol. 2011;106(12):2165–73.

    Article  CAS  PubMed  Google Scholar 

  113. Piche T, et al. Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut. 2009;58(2):196–201.

    Article  CAS  PubMed  Google Scholar 

  114. Stanghellini V, et al. Chronic intestinal pseudo-obstruction: manifestations, natural history and management. Neurogastroenterol Motil. 2007;19(6):440–52.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Allen A. Lee MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Lee, A.A. (2017). Nausea and Vomiting Related to Non-esophageal and Non-Gastric Diseases of the Gastrointestinal Tract. In: Koch, K., Hasler, W. (eds) Nausea and Vomiting. Springer, Cham. https://doi.org/10.1007/978-3-319-34076-0_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-34076-0_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-34074-6

  • Online ISBN: 978-3-319-34076-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics