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Future Directions in Understanding Nausea and Vomiting

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Abstract

Nausea and vomiting are important and debilitating symptoms to patients, but can also be frustrating for physicians since treatments are often ineffective. Understanding of nausea and vomiting from pathophysiologic and treatment standpoints is advancing, particularly in regard to gastroparesis, post-op ileus, and chemotherapy. This chapter reviews aspects of our current understanding of nausea and vomiting and discusses future directions for nausea and vomiting research. Future directions discussed include: (1) better characterization of neural pathways and receptors mediating nausea and vomiting; (2) improving evaluation of patients with chronic nausea and vomiting; and (3) improving treatments and enhancing drug development.

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References

  1. Peery AF, Crockett SD, Barritt AS, Dellon ES, Eluri S, Gangarosa LM, Jensen ET, Lund JL, Pasricha S, Runge T, Schmidt M, Shaheen NJ, Sandler RS. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015;149:1731–41.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Parkman H, Hasler W, Fisher R. American gastroenterological association technical review on the diagnosis and treatment of gastroparesis. Gastroenterology. 2004;127:1592–622.

    Article  PubMed  Google Scholar 

  3. Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Abell TL, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. Gastroenterology. 2011;140:101–15.

    Article  PubMed  Google Scholar 

  4. Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Calles J, Abell TL, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Similarities and differences between diabetic and idiopathic gastroparesis. Clin Gastroenterol Hepatol. 2011;9:1056–64.

    Article  PubMed  Google Scholar 

  5. Jaffe JK, Paladugu S, Gaughan JP, Parkman HP. Characteristics of nausea and its effects on quality of life in diabetic and idiopathic gastroparesis. J Clin Gastroenterol. 2011;45:317–21.

    Article  PubMed  Google Scholar 

  6. Muth ER, Stern RM, Thayer JF, et al. Assessment of the multiple dimensions of nausea: the nausea profile (NP). J Psychosomatic Res. 1996;40:511–20.

    Article  CAS  Google Scholar 

  7. Stapleton J, Wo JM. Current treatment of nausea and vomiting associated with gastroparesis: antiemetics, prokinetics, tricyclics. Gastrointest Endoscopy Clin N Am. 2009;19:57–72.

    Article  Google Scholar 

  8. Pasricha PJ, Colvin R, Yates K, Hasler WL, Abell TL, Ünalp-Arida A, Nguyen L, Farrugia G, Koch KL, Parkman HP, Snape WJ, Lee L, Tonascia J, Hamilton F. Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying. Clin Gastroenterol Hepatol. 2011;9:567–76.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Rentz A, Kahrilas P, Stanghellini V, et al. Development and psychometric evaluation of the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) in patients with upper gastrointestinal disorders. Qual Life Res. 2004;13:1737–49.

    Article  CAS  PubMed  Google Scholar 

  10. Cherian D, Parkman HP. Nausea and vomiting in diabetic and idiopathic gastroparesis. Neurogastroenterol Motil. 2012;24:217–22.

    Article  CAS  PubMed  Google Scholar 

  11. Martin A, Pearson J, Cai B, Elmer M, Horgan K, Lindley C. Assessing the impact of chemotherapy-induced nausea and vomiting on patients’ daily lives: a modified version of the Functional Living Index-Emesis (FLIE) with 5-day recall. Support Care Cancer. 2003;11:522–7.

    Article  CAS  PubMed  Google Scholar 

  12. Bytzer P, Talley N, Leemon M, Young L, Jones M, Horowitz M. Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults. Arch Intern Med. 2001;161:1989–96.

    Article  CAS  PubMed  Google Scholar 

  13. Revicki DA, Camilleri M, Kuo B, Szarka LA, McCormack J, Parkman HP. Evaluating symptom outcomes in gastroparesis clinical trials: validity and responsiveness of the gastroparesis cardinal symptom index-daily diary (GCSI-DD). Neurogastroenterol Motil. 2012;24:456–63.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Henry P. Parkman MD .

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Arasu, S., Parkman, H.P. (2017). Future Directions in Understanding Nausea and Vomiting. In: Koch, K., Hasler, W. (eds) Nausea and Vomiting. Springer, Cham. https://doi.org/10.1007/978-3-319-34076-0_15

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  • DOI: https://doi.org/10.1007/978-3-319-34076-0_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-34074-6

  • Online ISBN: 978-3-319-34076-0

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