Abstract
It was Monday and I was headed for the airport. That weekend had been spent sweating out the data from six previous experiments where long-term brain hypoperfusion had been induced in young and aged rats. My own brain needed a rest and I was looking forward to sleeping for a few hours on the flight from Montreal to Paris where I was scheduled to give a talk the next day.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Marshall RS. Effects of altered cerebral hemodynamics on cognitive function. J Alzheimers Dis. 2012;32(3):633–42.
de la Torre JC, Fortin T, Park GA, Saunders JK, Kozlowski P, Butler K, de Socarraz H, Pappas B, Richard M. Aged but not young rats develop metabolic, memory deficits after chronic brain ischaemia. Neurol Res. 1992;14(2 Suppl):177–80.
de la Torre JC, Fortin T, Park GA, Butler KS, Kozlowski P, Pappas BA, de Socarraz H, Saunders JK, Richard MT. Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats. Brain Res. 1992;582(2):186–95.
de la Torre JC, Fortin T. A chronic physiological rat model of dementia. Behav Brain Res. 1994;63(1):35–40.
Henderson B, de la Torre JC. Reversal of chronic ischemia in the adult rat: common carotid anastomosis and improvement in memory dysfunction. Soc Neurosci. 1999;25:55.
Gustafson L, Hagberg B. Emotional behaviour, personality changes and cognitive reduction in presenile dementia: related to regional cerebral blood flow. Acta Psychiatr Scand Suppl. 1975;257:37–71.
Hedlund S, Koheler V, Nylin G, Olsson R, Regnstroem O, Rothstroem E, Astroem KE. Cerebral blood flow in dementia. Acta Psychiatr Scand. 1964;40:77–106.
Hagberg B, Ingvar DH. Intellectual impairment in presenile dementia related to regional cerebral blood flow. Act Nerv Super (Praha). 1977;19(Suppl 2):350–1.
Davis DG, Schmitt FA, Wekstein DR, Markesbery WR. Alzheimer neuropathologic alterations in aged cognitively normal subjects. J Neuropathol Exp Neurol. 1999;58:376–88.
Giannakopoulos P, Herrmann FR, Bussiere T, Bouras C, Kövari E, Perl DP, Morrison JH, Gold G, Hof PR. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease. Neurology. 2003;60:1495–500.
Price JL, McKeel DW Jr, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC. Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging. 2009;30:1026–36.
Shimada H, Ataka S, Tomiyama T, Takechi H, Mori H, Miki T. Clinical course of patients with familial early-onset Alzheimer’s disease potentially lacking senile plaques bearing the E693Δ mutation in amyloid precursor protein. Dement Geriatr Cogn Disord. 2011;32(1):45–54.
Verclytte S, Lopes R, Lenfant P, Rollin A, Semah F, Leclerc X, Pasquier F, Delmaire C. Cerebral hypoperfusion and hypometabolism detected by arterial spin labeling MRI and FDG-PET in early-onset Alzheimer’s disease. J Neuroimaging. 2015. (In press).
de la Torre JC. Does brain microvessel pathology provoke Alzheimer’s disease? Soc Neurosci Abstr. 1992;18:564.
Fung YC. Biomechanics: circulation. New York: Springer; 1984.
de la Torre JC, Mussivand T. Can disturbed brain microcirculation cause Alzheimer’s disease? Neurol Res. 1993;15:146–53.
Kuhn TS. The structure of scientific revolutions. 3rd ed. Chicago, Illinois: The University of Chicago Press; 1996, p. 24.
de la Torre JC. Impaired brain microcirculation may trigger Alzheimer’s disease. Neurosci Biobehav Rev. 1994;18(3):397–401.
de la Torre JC. Hemodynamic consequences of deformed microvessels in the brain in Alzheimer’s disease. Ann NY Acad Sci. 1997;26(826):75–91.
Breteler MM. Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective. Neurobiol Aging. 2000;21(2):153–60.
de Jong GI, Farkas E, Plass J, Keijser JN, de la Torre JC, Luiten PGM. Cerebral hypoperfusion yields capillary damage in hippocampus CA1 that correlates to spatial memory impairment. Neuroscience. 1999;91:203–10.
de la Torre JC, Hachinski, V. (eds.) Cerebrovascular pathology in Alzheimer’s Disease. Ann NY Acad Sci. 1997;826:1–523.
Salloway S, Sperling R, Fox NC, et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer’s disease. N Engl J Med. 2014;370:322–33.
Doody RS, Thomas RG, Farlow M, et al. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease. N Engl J Med. 2014;370:311–21.
de la Torre JC. Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer’s pathogenesis. Neurobiol Aging. 2000;21(2):331–42.
Leenders KL, Perani D, Lammertsma AA, Heather JD, Buckingham P, Healy MJR, Gibbs JM, Wise RJS, Hatazawa J, Herold S, Beaney RP, Brooks DJ, Spinks T, Rhodes C, Frackowiak RS, Jones T. Cerebral blood flow, blood volume and oxygen utilization. Brain. 1990;113:24–47.
de la Torre JC. Alzheimer’s disease is a vasocognopathy: a new term to describe its nature. Neurol Res. 2004;26(5):517–24.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
de la Torre, J.C. (2016). A Personal Account of How a Scientific Hypothesis Blooms into a Life of Its Own. In: Alzheimer’s Turning Point. Springer, Cham. https://doi.org/10.1007/978-3-319-34057-9_14
Download citation
DOI: https://doi.org/10.1007/978-3-319-34057-9_14
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-34056-2
Online ISBN: 978-3-319-34057-9
eBook Packages: MedicineMedicine (R0)