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tDCS and Magnetic Resonance Imaging

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Transcranial Direct Current Stimulation in Neuropsychiatric Disorders

Abstract

Transcranial direct current stimulation (tDCS) is an increasingly promising potential therapeutic intervention in the treatment of a range of psychiatric and neurological conditions. However, before its full potential can be utilised more must be understood about its effects on the underlying brain tissue, both in regions local to the site of stimulation and those more anatomically distant. Magnetic resonance imaging approaches have the potential to study the modulation of brain activity by tDCS, and here we review the functional MRI and MR spectroscopy studies involving tDCS. We review the basis of the most commonly used approaches for both fMRI acquired at rest and during a task performance. We then go on to summarise the studies that have been performed to date in healthy controls and in patients with a range of psychiatric conditions, before discussing what conclusions can be drawn. It is to be hoped that this will prove a useful summary both for clinicians who wish to understand more about the neurophysiological basis of tDCS and for researchers who wish to perform their own tDCS/MR experiments.

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    Authors and Affiliations

    1. Oxford Centre for Functional MRI of the Brain (FMRIB), Department of Clinical Neurosciences, University of Oxford, Oxford, UK

      Ainslie Johnstone, Emily Hinson & Charlotte J. Stagg

    2. Oxford Centre for Human Brain Activity (OHBA), Department of Psychiatry, University of Oxford, Oxford, UK

      Emily Hinson & Charlotte J. Stagg

    3. FMRIB, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK

      Charlotte J. Stagg

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    1. Ainslie Johnstone
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    2. Emily Hinson
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    3. Charlotte J. Stagg
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    Correspondence to Charlotte J. Stagg .

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    Editors and Affiliations

    1. Interdisciplinary Center for Applied Neuromodulation Department and Institute of Psychiatry Laboratory of Neurosciences (LIM-27), University Hospital and Service of Interdisciplinary Neuromodulation University of São Paulo, São Paulo, Brazil

      André Brunoni

    2. Department of Psychology and Neurosciences, Leibniz Research Center for Working Environments and Human Factors, Dortmund, Germany

      Michael Nitsche

    3. School of Psychiatry Black Dog Institute & St George Hospital, University of New South Wales, Sydney, New South Wales, Australia

      Colleen Loo

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    Johnstone, A., Hinson, E., Stagg, C.J. (2016). tDCS and Magnetic Resonance Imaging. In: Brunoni, A., Nitsche, M., Loo, C. (eds) Transcranial Direct Current Stimulation in Neuropsychiatric Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-33967-2_10

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