Abstract
Aphthosis is an inflammatory disease characterized by painful recurrent oral ulcerations. The cause of aphthosis is unknown, and several studies indicate a role for the immune system in the physiopathogenesis of this disease. Oral lesions appear mainly on nonkeratinized mucosa as painful, regular, round or oval ulcers covered with a gray pseudomembrane and surrounded by an erythematous halo. The diagnosis of aphthosis is mainly established on clinical grounds. Treatment depends on the severity, recurrence rate, and response to previous therapies.
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Glossary
- Aphtha
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Synonymous to aphthosis. Also used as the description of the individual ulcer of the disease.
- Aphthosis
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A disease characterized by bursts of oral ulcerations, accompanied or not by ulcerations elsewhere (usually genitals) and systemic complaints.
- Dapsone
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Diaminodiphenyl sulfone (DDS), an antibiotic used in the treatment of leprosy and as an anti-inflammatory drug in several noninfectious skin diseases.
- Herpetiform ulceration
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One of several clinical types of aphthae, i.e., one that presents as multiple subintrant small ulcerations.
- Oral ulcer
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Any lesion characterized by loss of the oral epithelium.
- Thalidomide
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An immunomodulatory drug that is the prototype of the thalidomide class of drugs.
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Fernandes, J.D., Nico, M.M.S. (2018). Aphthae. In: Bonamigo, R., Dornelles, S. (eds) Dermatology in Public Health Environments. Springer, Cham. https://doi.org/10.1007/978-3-319-33919-1_25
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DOI: https://doi.org/10.1007/978-3-319-33919-1_25
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