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Neuroimaging Phenotypes in Zebrafish

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The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish

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Abstract

The zebrafish has become an established model in neuroscience due to the ease with which gene discovery, chemical screening, behaviour, and disease modelling can be performed. More recently, neuroimaging, a crucial pre-clinical technique for probing tissue structure, examining volumetric changes, and studying in vivo brain activity has also been applied to zebrafish. The zebrafish brain is particularly attractive for neuroimaging due to its small size, numerous translucent strains, and distinct forebrain organization. In this chapter we discuss the range of imaging techniques which have been utilized to examine the zebrafish brain. While many of these methods have only begun to be utilized in zebrafish, correlating neuroimaging phenotypes with behaviour in zebrafish has a bright future.

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Acknowledgements

The authors acknowledge the support of the National Institute of Health (5R03NS077295-02) and the National Imaging Facility. JFPU was also supported by a University of Queensland Early Career Research Award.

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Authors and Affiliations

  1. Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia

    Jeremy F. P. Ullmann & Andrew L. Janke

  2. Epilpesy Genetics Program, Department of Neurology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA

    Jeremy F. P. Ullmann

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  1. Jeremy F. P. Ullmann
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  2. Andrew L. Janke
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Correspondence to Jeremy F. P. Ullmann .

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Editors and Affiliations

  1. The International Zebrafish Neurosceince Research Consortium (ZNRC) and ZENEREI Research Center, Slidell, Louisiana, USA

    Allan V. Kalueff

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Ullmann, J.F.P., Janke, A.L. (2017). Neuroimaging Phenotypes in Zebrafish. In: Kalueff, A. (eds) The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish. Springer, Cham. https://doi.org/10.1007/978-3-319-33774-6_13

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