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Stem Cell-Based Therapies for Parkinson’s Disease

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Neurological Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive death of dopaminergic neurons (DAn) in the substantia nigra pars compacta (SNpc). The primary motor symptoms include tremors, rigidity and bradykinesia. Current treatments for PD are only symptomatic and do not prevent disease progression. In recent years, stem cells have become an attractive option to investigate and treat PD. In fact, transplants of fetal ventral mesencephalic cells (which are rich in dopaminergic neuroblasts) have provided proof of concept that cell replacement therapy may be a good option for improving motor symptoms in some PD patients. Although its widespread clinical use is still not possible due to ethical aspects and limited availability of tissue. It is therefore necessary to find alternative cellular sources such as stem cells. Stem cell therapies may exert their action through several mechanisms such as cell replacement, trophic and immunomodulatory actions. In this book chapter we summarize the most recent and relevant clinical studies based on cell therapy for PD treatment. We provide an overview of the different types of human stem cells available, their main properties and how they are being used as a possible therapy for the treatment of PD.

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Acknowledgements

Research in our laboratory was funded by the MICINN-ISCIII (PI-10/00291 and MPY1412/09), MINECO (SAF2015-71140-R) and Comunidad Autónoma de Madrid (NEUROSTEMCM consortium; S2010/BMD-2336).

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Authors and Affiliations

  1. Unidad de Regeneración Neural, Unidad Funcional de Investigación de Enfermedades Crónicas, Instituto de Salud Carlos III (ISCIII), 28220, Majadahonda, Madrid, Spain

    Charlotte Palmer & Isabel Liste PhD

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  1. Charlotte Palmer
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  2. Isabel Liste PhD
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Correspondence to Isabel Liste PhD .

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Editors and Affiliations

  1. Laboratory of Stem Cell Research and Application, University of Science Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Palmer, C., Liste, I. (2017). Stem Cell-Based Therapies for Parkinson’s Disease. In: Pham, P. (eds) Neurological Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-33720-3_5

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