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MR Spectroscopy in Multiple Sclerosis

Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

Multiple Sclerosis is a chronic inflammatory demyelinating disorder of the central nervous system. 1H-MRS provides us with additional information on the chemical pathology within the brain and spinal cord in MS patients, when compared to conventional MRI. This has enhanced our understanding of the pathogenesis and natural history in multiple sclerosis. It has proved a useful biomarker of neurodegeneration, as reflected by a decrease in the levels of the neuronal marker, N-acetylaspartate. Changes in choline and myo-inositol have also informed us of the importance of monitoring changes in myelin damage and repair and of the extent of gliosis. This chapter will provide an overview of 1H-MRS in the brain and spinal cord in clinical and preclinical studies in multiple sclerosis. We will also discuss the future potential of 1H-MRS in multiple sclerosis and its promising applications.

Keywords

Multiple sclerosis MR spectroscopy Brain Spinal cord White matter Grey matter Disability Neurodegeneration Inflammation Progression 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.NMR Research Unit, Queen Square MS CentreUCL Institute of NeurologyLondonUK
  2. 2.NIHR, UCL/UCLH Biomedical Research CentreLondonUK

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