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Magnetic Resonance Spectroscopy in Prion Diseases

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Book cover Magnetic Resonance Spectroscopy of Degenerative Brain Diseases

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

Prion diseases are uncommon dementias linked to the accumulation in the brain of humans and other mammals of an “infectious” autologous protein. The rapid clinical deterioration of the patients makes them difficult to study with MRS. Their spectroscopic profile includes decreased N-acetylaspartate and increased myo-inositol, reflecting the neuronal loss and gliosis characteristics of these pathologies.

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References

  1. Imran M, Mahmood S (2011) An overview of animal prion diseases. Virol J 8:493

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Imran M, Mahmood S (2011) An overview of human prion diseases. Virol J 8:559

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Meissner B, Körtner K, Bartl M, Jastrow U, Mollenhauer B, Schröter A, Finkenstaedt M et al (2004) Sporadic Creutzfeldt-Jakob disease: magnetic resonance imaging and clinical findings. Neurology 63:450–456

    Article  CAS  PubMed  Google Scholar 

  4. Zerr I, Kallenberg K, Summers DM, Romero C, Taratuto A, Heinemann U, Breithaupt M et al (2009) Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease. Brain 132:2659–2668

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Letourneau-Guillon L, Wada R, Kucharczyk W (2012) Imaging of prion diseases. J Magn Reson Imaging 35:998–1012

    Article  PubMed  Google Scholar 

  6. Fulbright RK, Kingsley PB, Guo X, Hoffmann C, Kahana E, Chapman JC, Prohovnik I (2006) The imaging appearance of Creutzfeldt-Jakob disease caused by the E200K mutation. Magn Reson Imaging 24:1121–1129

    Article  CAS  PubMed  Google Scholar 

  7. Hauw JJ, Sazdovitch V, Laplanche JL, Peoc’h K, Kopp N, Kemeny J, Privat N et al (2000) Neuropathologic variants of sporadic Creutzfeldt-Jakob disease and codon 129 of PrP gene. Neurology 54:1641–1646

    Article  CAS  PubMed  Google Scholar 

  8. Fujita K, Harada M, Yuasa T, Sasaki M, Izumi Y, Kaji R (2011) Temporal evolution of sporadic Creutzfeldt–Jakob disease monitored by 3-Tesla MR spectroscopy. J Neurol 258:1368–1370

    Article  PubMed  Google Scholar 

  9. Bell JD, Cox IJ, Williams SC, Belton PS, McConnell I, Hope J (1991) In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy. J Gen Virol 72(Pt 10):2419–2423

    Article  CAS  PubMed  Google Scholar 

  10. Behar KL, Boucher R, Fritch W, Manuelidis L (1998) Changes in N-acetylaspartate and myo-inositol detected in the cerebral cortex of hamsters with Creutzfeldt-Jakob disease. Magn Reson Imaging 16:963–968

    Article  CAS  PubMed  Google Scholar 

  11. Haïk S, Galanaud D, Linguraru MG, Peoc’h K, Privat N, Faucheux BA, Ayache N et al (2008) In vivo detection of thalamic gliosis: a pathoradiologic demonstration in familial fatal insomnia. Arch Neurol 65:545–549

    Article  PubMed  Google Scholar 

  12. Waldman AD, Cordery RJ, MacManus DG, Godbolt A, Collinge J, Rossor MN (2006) Regional brain metabolite abnormalities in inherited prion disease and asymptomatic gene carriers demonstrated in vivo by quantitative proton magnetic resonance spectroscopy. Neuroradiology 48:428–433

    Article  CAS  PubMed  Google Scholar 

  13. Miller BL, Moats RA, Shonk T, Ernst T, Woolley S, Ross BD (1993) Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy. Radiology 187:433–437

    Article  CAS  PubMed  Google Scholar 

  14. Akhvlediani T, Henning A, Sándor PS, Boesiger P, Jung HH (2010) Adaptive metabolic changes in CADASIL white matter. J Neurol 257:171–177

    Article  CAS  PubMed  Google Scholar 

  15. Kim JH, Choi BS, Jung C, Chang Y, Kim S (2011) Diffusion-weighted imaging and magnetic resonance spectroscopy of sporadic Creutzfeldt-Jakob disease: correlation with clinical course. Neuroradiology 53:939–945

    Article  PubMed  Google Scholar 

  16. Cordery RJ, MacManus D, Godbolt A, Rossor MN, Waldman AD (2006) Short TE quantitative proton magnetic resonance spectroscopy in variant Creutzfeldt-Jakob disease. Eur Radiol 16:1692–1698

    Article  CAS  PubMed  Google Scholar 

  17. Galanaud D, Dormont D, Grabli D, Charles P, Hauw JJ, Lubetzki C, Brandel JP et al (2002) MR spectroscopic pulvinar sign in a case of variant Creutzfeldt-Jakob disease. J Neuroradiol 29:285–287

    CAS  PubMed  Google Scholar 

  18. Galanaud D, Haik S, Linguraru MG, Ranjeva JP, Faucheux B, Kaphan E, Ayache N et al (2010) Combined diffusion imaging and MR spectroscopy in the diagnosis of human prion diseases. Am J Neuroradiol 31:1311–1318

    Article  PubMed  PubMed Central  Google Scholar 

  19. Oppenheim C, Zuber M, Galanaud D, Detilleux M, Bolgert F, Mas JL, Chiras J et al (2004) Spectroscopy and serial diffusion MR findings in hGH-Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry 75:1066–1069

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Neuroradiology & Institut du Cerveau et de la Moëlle, Pitié Salpêtrière Hospital, Paris, France

    Damien Galanaud

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  1. Damien Galanaud
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Correspondence to Damien Galanaud .

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Editors and Affiliations

  1. University of Minnesota Medical School, Center Magnetic Resonance Research University of Minnesota Medical School, Minneapolis, MN, USA

    Gülin Öz

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Galanaud, D. (2016). Magnetic Resonance Spectroscopy in Prion Diseases. In: Öz, G. (eds) Magnetic Resonance Spectroscopy of Degenerative Brain Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-33555-1_10

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