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Magnetic Resonance Spectroscopy in Prion Diseases

Chapter
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Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

Prion diseases are uncommon dementias linked to the accumulation in the brain of humans and other mammals of an “infectious” autologous protein. The rapid clinical deterioration of the patients makes them difficult to study with MRS. Their spectroscopic profile includes decreased N-acetylaspartate and increased myo-inositol, reflecting the neuronal loss and gliosis characteristics of these pathologies.

Keywords

Prion-related protein Creutzfeldt–Jakob disease Fatal familial insomnia Gerstmann–Straussler–Scheinker disease Scrapie 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Neuroradiology & Institut du Cerveau et de la MoëllePitié Salpêtrière HospitalParisFrance

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