Magnetic Resonance Spectroscopy in Prion Diseases
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Prion diseases are uncommon dementias linked to the accumulation in the brain of humans and other mammals of an “infectious” autologous protein. The rapid clinical deterioration of the patients makes them difficult to study with MRS. Their spectroscopic profile includes decreased N-acetylaspartate and increased myo-inositol, reflecting the neuronal loss and gliosis characteristics of these pathologies.
KeywordsPrion-related protein Creutzfeldt–Jakob disease Fatal familial insomnia Gerstmann–Straussler–Scheinker disease Scrapie
- 12.Waldman AD, Cordery RJ, MacManus DG, Godbolt A, Collinge J, Rossor MN (2006) Regional brain metabolite abnormalities in inherited prion disease and asymptomatic gene carriers demonstrated in vivo by quantitative proton magnetic resonance spectroscopy. Neuroradiology 48:428–433CrossRefPubMedGoogle Scholar