Skip to main content

Delivery of Anticancer Molecules Using Carbon Nanotubes

  • Chapter
  • First Online:
Surgical Tools and Medical Devices

Abstract

Since their discovery in 1991, carbon nanotubes (CNTs) have emerged as material structures with numerous potential applications with a number of products already in the market place. An exciting application, which is emerging, is the use of carbon nanotubes for drug delivery. In this chapter, we focus on the functionalization, mechanism of cellular update, and using carbon nanotubes for delivery of anticancer drugs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  1. Iijima, S. (1991). Helical microtubules of graphitic carbon. Letters to Nature, 354, 56–58.

    Article  Google Scholar 

  2. Sahooa, N. G., Ranab, S., Chob, J. W., Lia, L., & Chana, S. H. (2010). Polymer nanocomposites based on functionalized carbon nanotubes. Progress in Polymer Science, 35, 837–867.

    Article  Google Scholar 

  3. Ajayan, P. M., Stephan, O., Colliex, C., & Trauth, D. (1994). Aligned carbon nanotube arrays formed by cutting a polymer resin-nanotube composite. Science, 265, 1212–1214.

    Article  Google Scholar 

  4. Coleman, J. N., Khan, U., Blau, W. J., & Gun’ko, Y. K. (2006). Small but strong: A review of the mechanical properties of carbon nanotubes—polymer composites. Carbon, 44, 1624–1652.

    Article  Google Scholar 

  5. Valentin, N. P. (2004). Carbon nanotubes: Properties and application. Materials Science and Engineering, 43, 61–102.

    Article  Google Scholar 

  6. Plank, N. O. V., & Cheung, R. (2004). Functionalisation of carbon nanotubes for molecular electronics. Microelectronic Engineering, 73, 578–582.

    Article  Google Scholar 

  7. Star, A., Stoddart, J. F., Steuerman, D., Diehl, M., Boukai, A., Wong, E., et al. (2001). Preparation and properties of polymer-wrapped single-walled carbon nanotubes. Angewandte Chemie International, 40, 1721–1725.

    Article  Google Scholar 

  8. Bianco, A., Kostarelos, K., & Prato, M. (2005). Application of carbon nanotubes in drug delivery. Current Opinion in Chemical Biology, 9, 674–679.

    Article  Google Scholar 

  9. Elhissi, A. M., Ahmed, W., Ul Hassan, I., Dhanak, V. R., & D’Emanuele, A. (2012). Carbon nanotubes in cancer therapy and drug delivery. Journal of Drug Delivery, 2012. Article ID 837327.

    Google Scholar 

  10. Cho, K., Wang, X., Nie, S., Chen, Z., & Shin, D. M. (2008). Therapeutic nanoparticles for drug delivery in cancer. Clinical Cancer Research, 5, 1310–1316.

    Article  Google Scholar 

  11. Raffa, V., Ciofani, G., Vittorio, O., Riggio, C., & Cuschieri, A. (2010). Physicochemical properties affecting cellular uptake of carbon nanotubes. Nanomedicine, 1, 89–97.

    Article  Google Scholar 

  12. Faraji, H. A., & Wipf, P. (2009). Nanoparticles in cellular drug delivery. Bioorganic & Medicinal Chemistry, 17, 2950–2962.

    Article  Google Scholar 

  13. Jiang, W., Kim, B. Y. S., Rutka, J. T., & Chan, W. C. W. (2008). Nanoparticles-mediated cellular response is size-dependent. Nature Nanotechnology, 3, 145–150.

    Article  Google Scholar 

  14. Shi Kam, N. W., & Dai, H. (2005). Carbon nanotubes as intracellular protein transporters: Generality and biological functionality. Journal of the American Chemical Society, 127, 6021–6026.

    Article  Google Scholar 

  15. Liu, Z., Chen, K., Davis, C., Sherlock, S., Qizhen, C., Chen, X., et al. (2008). Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Research, 68, 6652–6658.

    Article  Google Scholar 

  16. Dai, H. (2002). Carbon nanotubes: Synthesis, integration, and properties. Accounts of Chemical Research, 35, 1035–1044.

    Article  Google Scholar 

  17. Van Tassel, K., & Goldman, R. (2010). Manufacturing the wings of icarus: FDA regulation of nanotechnology used in products for human consumption including food, dietary supplements, cosmetics and sunscreens. Journal of Law, Technology and Policy, 32, 2140–2183.

    Google Scholar 

  18. Jaracz, S., Chen, J., Kuznetsova, V. L., & Ojima, I. (2005). Recent advances in tumour targeting anticancer drug conjugates. Bioorganic & Medicinal Chemistry, 13, 5043–5054.

    Article  Google Scholar 

  19. Dhar, S., Liu, Z., Thomale, J., Dai, H., & Lippard, J. S. (2008). Targeted single-wall carbon nanotube-mediated Pt (IV) prodrug delivery using folate as a homing device. Journal of American Chemical Society, 130, 11467–11476.

    Article  Google Scholar 

  20. Low, P. S., & Antony, A. C. (2004). Folate receptor targeted drugs for cancer and inflammatory disease. Advanced Drug Delivery Review, 56, 1057–1238.

    Article  Google Scholar 

  21. Shim, M., Kam, W. S. N., Chen, J. R., Li, Y., & Dai, H. (2002). Functionalization of carbon nanotubes for biocompatibility and biomolecular recognition. Nanoletters, 2, 285–288.

    Article  Google Scholar 

  22. Antony, A. C. (1996). Folate receptors. Annual Review of Nutrition, 16, 501–521.

    Article  Google Scholar 

  23. Nie, H., Wei, G., Yuan, Y., Dou, Z., Zujin, S., Liu, Z., et al. (2010). PEGylation of double-walled carbon nanotubes for increasing their solubility in water. Nanoresearch, 3, 103–109.

    Google Scholar 

  24. Prencipe, G., Tabakman, M. S., Welsher, K., Liu, Z., Goodwin, P. A., Zhang, L., et al. (2009). PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation. Journal of American Chemical Society, 131, 4787–4793.

    Article  Google Scholar 

  25. Veronese, F. M., & Mero, A. (2008). The impact of PEGylation on biological therapies. Biodrugs, 22, 315–329.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Abdelbary Elhissi .

Editor information

Editors and Affiliations

Rights and permissions

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 2.5 International License (http://creativecommons.org/licenses/by-nc/2.5/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

The images or other third party material in this chapter are included in the chapter's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Ahmed, I., Javeed, A., Ahmed, W., Phoenix, D.A., Elhissi, A., Jackson, M.J. (2016). Delivery of Anticancer Molecules Using Carbon Nanotubes. In: Ahmed, W., Jackson, M. (eds) Surgical Tools and Medical Devices. Springer, Cham. https://doi.org/10.1007/978-3-319-33489-9_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-33489-9_18

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33487-5

  • Online ISBN: 978-3-319-33489-9

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics