Abstract
Since their discovery in 1991, carbon nanotubes (CNTs) have emerged as material structures with numerous potential applications with a number of products already in the market place. An exciting application, which is emerging, is the use of carbon nanotubes for drug delivery. In this chapter, we focus on the functionalization, mechanism of cellular update, and using carbon nanotubes for delivery of anticancer drugs.
References
Iijima, S. (1991). Helical microtubules of graphitic carbon. Letters to Nature, 354, 56–58.
Sahooa, N. G., Ranab, S., Chob, J. W., Lia, L., & Chana, S. H. (2010). Polymer nanocomposites based on functionalized carbon nanotubes. Progress in Polymer Science, 35, 837–867.
Ajayan, P. M., Stephan, O., Colliex, C., & Trauth, D. (1994). Aligned carbon nanotube arrays formed by cutting a polymer resin-nanotube composite. Science, 265, 1212–1214.
Coleman, J. N., Khan, U., Blau, W. J., & Gun’ko, Y. K. (2006). Small but strong: A review of the mechanical properties of carbon nanotubes—polymer composites. Carbon, 44, 1624–1652.
Valentin, N. P. (2004). Carbon nanotubes: Properties and application. Materials Science and Engineering, 43, 61–102.
Plank, N. O. V., & Cheung, R. (2004). Functionalisation of carbon nanotubes for molecular electronics. Microelectronic Engineering, 73, 578–582.
Star, A., Stoddart, J. F., Steuerman, D., Diehl, M., Boukai, A., Wong, E., et al. (2001). Preparation and properties of polymer-wrapped single-walled carbon nanotubes. Angewandte Chemie International, 40, 1721–1725.
Bianco, A., Kostarelos, K., & Prato, M. (2005). Application of carbon nanotubes in drug delivery. Current Opinion in Chemical Biology, 9, 674–679.
Elhissi, A. M., Ahmed, W., Ul Hassan, I., Dhanak, V. R., & D’Emanuele, A. (2012). Carbon nanotubes in cancer therapy and drug delivery. Journal of Drug Delivery, 2012. Article ID 837327.
Cho, K., Wang, X., Nie, S., Chen, Z., & Shin, D. M. (2008). Therapeutic nanoparticles for drug delivery in cancer. Clinical Cancer Research, 5, 1310–1316.
Raffa, V., Ciofani, G., Vittorio, O., Riggio, C., & Cuschieri, A. (2010). Physicochemical properties affecting cellular uptake of carbon nanotubes. Nanomedicine, 1, 89–97.
Faraji, H. A., & Wipf, P. (2009). Nanoparticles in cellular drug delivery. Bioorganic & Medicinal Chemistry, 17, 2950–2962.
Jiang, W., Kim, B. Y. S., Rutka, J. T., & Chan, W. C. W. (2008). Nanoparticles-mediated cellular response is size-dependent. Nature Nanotechnology, 3, 145–150.
Shi Kam, N. W., & Dai, H. (2005). Carbon nanotubes as intracellular protein transporters: Generality and biological functionality. Journal of the American Chemical Society, 127, 6021–6026.
Liu, Z., Chen, K., Davis, C., Sherlock, S., Qizhen, C., Chen, X., et al. (2008). Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Research, 68, 6652–6658.
Dai, H. (2002). Carbon nanotubes: Synthesis, integration, and properties. Accounts of Chemical Research, 35, 1035–1044.
Van Tassel, K., & Goldman, R. (2010). Manufacturing the wings of icarus: FDA regulation of nanotechnology used in products for human consumption including food, dietary supplements, cosmetics and sunscreens. Journal of Law, Technology and Policy, 32, 2140–2183.
Jaracz, S., Chen, J., Kuznetsova, V. L., & Ojima, I. (2005). Recent advances in tumour targeting anticancer drug conjugates. Bioorganic & Medicinal Chemistry, 13, 5043–5054.
Dhar, S., Liu, Z., Thomale, J., Dai, H., & Lippard, J. S. (2008). Targeted single-wall carbon nanotube-mediated Pt (IV) prodrug delivery using folate as a homing device. Journal of American Chemical Society, 130, 11467–11476.
Low, P. S., & Antony, A. C. (2004). Folate receptor targeted drugs for cancer and inflammatory disease. Advanced Drug Delivery Review, 56, 1057–1238.
Shim, M., Kam, W. S. N., Chen, J. R., Li, Y., & Dai, H. (2002). Functionalization of carbon nanotubes for biocompatibility and biomolecular recognition. Nanoletters, 2, 285–288.
Antony, A. C. (1996). Folate receptors. Annual Review of Nutrition, 16, 501–521.
Nie, H., Wei, G., Yuan, Y., Dou, Z., Zujin, S., Liu, Z., et al. (2010). PEGylation of double-walled carbon nanotubes for increasing their solubility in water. Nanoresearch, 3, 103–109.
Prencipe, G., Tabakman, M. S., Welsher, K., Liu, Z., Goodwin, P. A., Zhang, L., et al. (2009). PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation. Journal of American Chemical Society, 131, 4787–4793.
Veronese, F. M., & Mero, A. (2008). The impact of PEGylation on biological therapies. Biodrugs, 22, 315–329.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 2.5 International License (http://creativecommons.org/licenses/by-nc/2.5/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
The images or other third party material in this chapter are included in the chapter's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Ahmed, I., Javeed, A., Ahmed, W., Phoenix, D.A., Elhissi, A., Jackson, M.J. (2016). Delivery of Anticancer Molecules Using Carbon Nanotubes. In: Ahmed, W., Jackson, M. (eds) Surgical Tools and Medical Devices. Springer, Cham. https://doi.org/10.1007/978-3-319-33489-9_18
Download citation
DOI: https://doi.org/10.1007/978-3-319-33489-9_18
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-33487-5
Online ISBN: 978-3-319-33489-9
eBook Packages: EngineeringEngineering (R0)