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Dental Stem Cells: Regenerative Potential pp 187–202Cite as

Dental Stem Cells for Tooth Regeneration

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Teeth develop as result of sequential and reciprocal interactions between oral epithelium and cranial neural crest-derived cells. Signaling molecules and specific transcription factors constitute a unique molecular imprint for odontogenesis and contribute to the generation of teeth with various and function-specific shapes. Teeth are vulnerable to external harmful agents, injuries, and pathologies that compromise their integrity and function. Although stem cells guarantee dental tissue repair and regeneration after injury or pathology, the natural regenerative capacity of dental tissues is limited, thus making unable the entire restoration of damaged teeth. In such cases, cell-based therapeutic approaches that consist of in vitro manipulation of stem cells and their consequent administration to patients are attractive alternatives to current dental treatments.

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Acknowledgements

This work was supported by funds of the University of Zurich (TAM and LJR) and the Polytechnic University of Marche (GO). The authors contributed to the planning, writing, critical reading, and editing of the present book chapter. The authors confirm that there are no conflicts of interest associated with this work.

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Authors and Affiliations

  1. Orofacial Development and Regeneration, Institute of Oral Biology, Centre for Dental Medicine, Medical Faculty, University of Zurich, Plattenstrasse 11, 8032, Zurich, Switzerland

    Thimios A. Mitsiadis & Lucia Jimenez-Rojo

  2. Department of Clinical Sciences and Stomatology, Polytechnic University of Marche, Ancona, Italy

    Giovanna Orsini

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  1. Thimios A. Mitsiadis
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Correspondence to Thimios A. Mitsiadis .

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  1. Department of Biomedical Sciences, University of Padova, Padova, Italy

    Barbara Zavan

  2. Department of Neurosciences, University of Padova, Padova, Italy

    Eriberto Bressan

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Mitsiadis, T.A., Orsini, G., Jimenez-Rojo, L. (2016). Dental Stem Cells for Tooth Regeneration. In: Zavan, B., Bressan, E. (eds) Dental Stem Cells: Regenerative Potential. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-33299-4_10

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