Abstract
Many topical treatments are used in the treatment of localized itch but controlled clinical trials are often lacking. Hence, menthol and derivates, camphor, urea, anesthesics, antihistamines, doxepin, calamine, methylene blue, raffinose, salicylates and strontium nitrate can be used. Prostangandin D2 agonists might be used in the future.
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References
Veldhuis NA, Poole DP, Grace M, McIntyre P, Bunnett NW. The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation. Pharmacol Rev. 2015;67:36–73.
Misery L, Brenaut E, Le Garrec R, Abasq C, Genestet S, Marcorelles P, Zagnoli F. Neuropathic pruritus. Nat Rev Neurol. 2014;10:408–16.
Han L, Dong X. Itch mechanisms and circuits. Annu Rev Biophys. 2014;43:331–55.
Patel T, Ishiuji Y, Yosipovitch G. Menthol: a refreshing look at this ancient compound. J Am Acad Dermatol. 2007;57:873–8.
Boulais N, Misery L. The epidermis: a sensory tissue. Eur J Dermatol. 2008;18:119–27.
Christensen AP, Corey DP. TRP channels in mechansosensation: direct or indirect activation? Nat Rev Neurosci. 2007;8:510–21.
Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007;448:204–8.
Green BG, Schoen KL. Thermal and nociceptive sensations from menthol and their suppression by dynamic contact. Behav Brain Res. 2007;176(2):284–91.
Lumpkin EA, Caterina MJ. Mechanisms of sensory transduction in the skin. Nature. 2007;445:858–65.
Karashima Y, Damann N, Prenen J, Talavera K, Segal A, Voets T, Nilius B. Bimodal action of menthol on the transient recptor potential channel TRPA1. J Neurosci. 2007;27:9874–84.
Biro T, Toth BI, Marincsak R, Dobrosi N, Geczy T, Paus R. TRP channels as novel players in the pathogenesis and therapy of itch. Biochem Biophys Acta. 2007;1772:1004–21.
Wilson SR, Bautista DM. Role of transient receptor potential channels in acute and chronic itch. In: Carstens E, Akiyama T, editors. Itch: mechanisms and treatment. Boca Raton: CRC Press; 2014.
Bromm B, Scharein E, Darsow U, Ring J. Effects of menthol and cold on histamine-induced itch and skin reactions in man. Neurosci Lett. 1995;187:157–60.
Yosipovitch G, Szolar C, Hui XY, Maibach H. Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. Arch Dermatol Res. 1996;288(5–6):245–8.
Angelova-Fischer I, Neufang G, Jung K, Fischer TW, Zillikens D. A randomized, investigator-blinded efficacy assessment study of stand-alone emollient use in mild to moderately severe atopic dermatitis flares. J Eur Acad Dermatol Venereol. 2014;28 Suppl 3:9–15.
Moqrich A, Hwang SW, Earley TJ, Petrus MJ, Murray AN, Spencer KS, et al. Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science. 2005;307:1468–72.
Swanbeck G, Rajka G. Antipruritic effect of urea solutions. An experimental and clinical study. Acta Derm Venereol. 1970;50:225–7.
Kopecky E, Jacobson S, Bch M, Hubley P, Palozzi L, Clarke H, et al. Safety and pharmacokinetics of EMLA in the treatment of postburn pruritus in pediatric patients: a pilot study. J Burn Care Rehabil. 2001;22:235–42.
Shuttleworth D, Hill S, Marks R, Connelly D. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol. 1988;119:535–40.
Weisshaar E, Forster C, Dotzer M, Heyer G. Experimentally induced pruritus and cutaneous reactions with topical antihistamine and local analgesics in atopic eczema. Skin Pharmacol. 1197;10:183–90.
Twycross R, Greaves MW, Handwerker H, Jones E, Libretto S, Szepietowski JC, et al. Itch: scratching more than the surface. Q J Med. 2003;96:7–26.
Hawro T, Fluhr JW, Mengeaud V, Redoulès D, Church MK, Maurer M, Metz M. Polidocanol inhibits cowhage – but not histamine – induced itch in humans. Exp Dermatol. 2014;23:922–3.
Eschler DC, Klein PA. An evidence-based review of the efficacy of topical antihistamines in the relief of pruritus. J Drugs Dermatol. 2010;9:992–7.
Greidig L, Moreno P. Doxepin incorporated into a dermatologic cream: an assessment of both doxepin antipruritic action and doxepin action as an inhibitor of papules, in allergen and histamine-caused pruritus. Allergol Immunopathol. 1999;27:265–70.
Drake LA, Fallon JD, Sober A. Relief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream. J Am Acad Dermatol. 1994;31:613–6.
Misery L, Mazharian R, Teurquety L, Cambazard F, Drouault Y, Cognat T, et al. Efficacité du Gel de calamine dans le prurit anal. Nouv Dermatol. 2004;23:7–9.
Mentes B, Akin M, Leventoglu S, Gultekin F, Oguz M. Intradermal methylene blue injection for the treatment of intractable idiopathic pruritus ani: results of 30 cases. Tech Coloproctol. 2004;8:11–4.
Samalavicius NE, Poskus T, Gupta RK, Lunevicius R. Long-term results of single intradermal 1% methylene blue injection for intractable idiopathic pruritus ani: a prospective study. Tech Coloproctol. 2012;16:295–9.
Sugimoto M, Arai I, Futaki N, Hashimoto Y, Sakurai T, Honma Y, et al. The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice. Eur J Pharmacol. 2007;564:196–203.
Campech M, Gavroy JP, Ster F, Griffe O, Téot L, Chavoin JP, et al. Etude de l’effet antiprurigineux du raffinose sur le tégument récemment épidermisé du grand brulé. Brûlures. 2002;11:219–22.
Misery L, Liège P, Cambazard F. Evaluation de l’efficacité et de la tolérance d’une crème contenant du raffinose au cours de la dermatite atopique. Nouv Dermatol. 2005;24:339–41.
Yosipovitch G, Sugeng MW, Chan H, Goon A, Ngim S, Goh CL. The effect of topically applied aspirin on localized circumscribed neurodermatitis. J Am Acad Dermatol. 2001;45:910–3.
Draelos Z. An evaluation of topical 3% salicylic acid and 1% hydrocortisone in the maintenance of scalp pruritus. J Cosmet Dermatol. 2005;4:193–7.
Thomsen JS, Simonsen L, Benfeldt E, Jensen SB, Serup J. The effect of topivally applied salicylic compounds on serotonin-induced scratching behavior in hairless rats. Exp Dermatol. 2002;11:370–5.
Zhai H, Hannon W, Hahn GS, Harper RA, Pelosi A, Maibach H. Strontium nitrate decreased histamine-induced itch magnitude and duration in man. Dermatology. 2000;200:244–6.
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Misery, L. (2016). Menthol, Camphor and Other Topical Treatments. In: Misery, L., Ständer, S. (eds) Pruritus. Springer, Cham. https://doi.org/10.1007/978-3-319-33142-3_47
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DOI: https://doi.org/10.1007/978-3-319-33142-3_47
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