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Pruriceptors

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Pruritus

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Abstract

Pruriceptors are peripheral sensory neurons that have the capacity to sense and respond to pruritogens. These fibers and the receptors, channels and mediators involved in their stimulation are discussed in this chapter. Our focus is on aspects that are most relevant to the clinic and clinical research communities. The potential for new therapeutic agents to inhibit these receptors, channels and mediators and thus the transduction of itch is described.

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Abbreviations

AITC:

Allyl isothiocyanate

BAM8-22:

Bovine adrenal medulla 8-22 peptide

BNP:

B-type natriuretic peptide

CGRP:

Calcitonin gene-related peptide

DAG:

Diacylglycerol

DRG:

Dorsal root ganglion

GPCR:

G-protein coupled receptor

GRPR:

Gastrin-releasing peptide receptor

IP3:

Inositoltriphosphate

LPA:

Lysophosphatidic acid

LPC:

Lysophosphatidyl choline

Mrgprs:

Mas-related G-protein coupled receptors

NaV:

Sodium channel

NGF:

Nerve growth factor

NK1:

Neurokinin 1 receptor

NPR-A:

Natriuretic peptide receptor-A

PARs:

Protease-activated receptors

PIP2:

Phosphatidylinositol

PKCδ:

Phodphokinase Cδ

PLCβ3:

Phospholipase Cβ3

TLR:

Toll-like receptor

TRP:

Transient receptor potential channel

TRPA1:

Transient receptor potential ankyrin subfamily member 1

TRPV1:

Transient receptor potential channel subfamily V member 1

TRPV4:

Transient receptor potential channel subfamily V member 4

TSLP:

Thymic stromal lymphopoietin

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Author information

Authors and Affiliations

  1. Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, 149, 13th Street, Charlestown, MA, 02129, USA

    Ethan A. Lerner MD, PhD

Authors
  1. Ethan A. Lerner MD, PhD
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Correspondence to Ethan A. Lerner MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Dermatology, University of Brest, Brest, France

    Laurent Misery

  2. Center of Chronic Pruritus, University Hospital Münster, Münster, Nordrhein-Westfalen, Germany

    Sonja Ständer

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© 2016 Springer-Verlag London

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Lerner, E.A. (2016). Pruriceptors. In: Misery, L., Ständer, S. (eds) Pruritus. Springer, Cham. https://doi.org/10.1007/978-3-319-33142-3_2

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  • DOI: https://doi.org/10.1007/978-3-319-33142-3_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33140-9

  • Online ISBN: 978-3-319-33142-3

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