Abstract
The measles–mumps–rubella (MMR) vaccine has nearly eliminated subacute sclerosing panencephalitis (SSPE), a rare complication of measles, and other measles-virus-related neurological disorders in populations with compulsory vaccination programs (http://www.cdc.gov/measles/about/history.html). Nonetheless, the neurological complications of measles, including SSPE, remain threats to unimmunized persons, especially children who live in measles-endemic regions and acquire measles at young ages. This chapter summarizes current information regarding the epidemiology, virology, clinical manifestations, diagnosis, and management of measles and its neurological complications, focusing on SSPE.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abe Y, Hashimoto K, Linuma K et al (2012) J Child Neurol 15:1529–1533
Allen IV, McQuaid S, McMahon J et al (1996) J Neuropathol Exp Neurol 55:471–480
American Academy of Pediatrics (2012) Measles. In: Pickering LK, Baker CJ, Kimberlin DW (eds) Red book: 2012 report of the committee on infectious diseases, 28th ed. American Academy of Pediatrics, Elk Grove Village
Anlar B, Saatçi I, Köse G, Yalaz K (1996) Neurology 47:1278–1283
Anlar B, Yalaz K, Köse G, Saygi S (1998) J Child Neurol 13:557–559
Anlar B, Köse G, Gürer Y et al (2001a) Infection 29:192–195
Anlar B, Söylemezoğlu F, Aysun S et al (2001b) J Child Neurol 16:895–900
Ayata M, Hirano A, Wong TC (1989) J Virol 63:1162–1173
Aysun S, Sanai O, Renda Y et al (1984) Brain Dev 6:391–396
Baczko K, Carter MJ, Billeter M et al (1984) Virus Res 1:585–595
Baczko K, Liebert UG, Billeter M et al (1986) J Virol 59:472–478
Baczko K, Liebert UG, Cattaneo R et al (1988) J Infect Dis 158:144–150
Baczko K, Lampe J, Liebert UG et al (1993) Virology 197:188–195
Baron MD, Barrett T (1995) Vet Microbiol 44:175–185
Black FL (1966) J Theor Biol 11:207–211
Bouteille M, Fontaine C, Vedrenne C et al (1965) Rev Neurol 113:454
Buchanan R, Bonthius DJ (2012) Semin Pediatr Neurol 19:107–114
Burgoon MP, Keays KM, Owens GP et al (2005) Proc Natl Acad Sci U S A 102:7245–7250
Carole F (1987) Phillips. In: Behrman RE, Vaughan III VC, Nelson WE (eds) Nelson pediatrics, 13th edn. W.B. Saunders, Co., Philadelphia
Carsillo T, Carsillo M, Niewiesk S et al (2004) Brain Res 1004:73–82
Cattaneo R, Schmid A, Rebmann G et al (1986) Virology 154:97–107
Cattaneo R, Schmid A, Billeter MA et al (1988a) J Virol 62:1388–1397
Cattaneo R, Schmid A, Eschle D et al (1988b) Cell 55:255–265
Cattaneo R, Schmid A, Spielhofer P et al (1989) Virology 173:415–425
Centers for Disease Control and Prevention (1991) MMWR Morb Mortal Wkly Rep 40:36–39
Centers for Disease Control and Prevention. http://www.cdc.gov/measles/about/history.html. Accessed 5 Mar 2015
Centers for Disease Control and Prevention. http://www.cdc.gov/measles/about/transmission.html. Accessed 5 Mar 2015
Chen TT, Watanabe I, Zeman W et al (1969) Science 163:1193–1194
Chua KB, Wang LF, Lam SK, Eaton BT (2002) Arch Virol 147:1323–1348
Connolly JH, Allen IV, Hurwitz LJ, Millar JH (1967) Lancet 11:542–544
De Swart RL, Ludlow M, de Witte L et al (2007) PLoS Pathog 3:e178
Delpeut S, Noyce RS, Siu RWC, Richardson CD (2012) Curr Opin Virol 2:773–783
Demir N, Cokar O, Bolukbasi F et al (2013) J Clin Neurophysiol 30:348–356
Derakhshan I, Massoud A, Foroozanfar N et al (1981) Neurology 31:177–178
Dhib-Jalbut SS, Jacobson S, McFarlin DE et al (1989) Ann Neurol 25:272–280
Dorig RE, Marcil A, Chopra A, Richardson CD (1993) Cell 75:295–305
Duprex WP, McQuaid S, Roscic-Mrkic B et al (2000) J Virol 74:7972–7979
Dyken PR, Cunningham SC, Ward LC (1989) Pediatr Neurol 5:339–341
Ehrengruber MU, Ehler E, Billeter M, Naim HY (2002) J Virol 76:5720–5728
Epstein JH, Field HE, Luby S et al (2006) Curr Infect Dis Rep 8:59–65
Ferreira CSA, Frenzke M, Leonard VHJ et al (2010) J Virol 84:3033–3042
Freeman AF, Jacobsohn DA, Shulman ST et al (2004) Pediatrics 114:e657–e660
Fukuyama Y, Nihei K, Matsumoto S et al (1987) Brain Dev 9:270–282
Furese Y, Suzuki A, Oshitani H (2010) Virol J 7:52. doi:10.1186/1743-422X-7-52
Garg RK (2008) J Neurol 225:1861–1871
Gascon GG (1999) Sem Pediatr Neurol 3:260–269
Gascon GG, the International Consortium on Subacute Sclerosing Panencephalitis (2003) J Child Neurol 18:819–827
Gascon GG, Yamani S, Crowell J et al (1994) Brain Dev 15:364–553.
Ginsberg T, Glasky AJ (1977) Ann N Y Acad Sci 284:128–138
Haddad FS, Risk WS, Jabbour JT (1977) Ann Neurol 1:211–217
Halpin K, Young PL, Field HE, Mackenzie JS (2000) J Gen Virol 81:1927–1932
Halsey NA, Modlin JF, Jabbour JT et al (1980) Am J Epidemiol 111:415–424
Hara T, Yamashita S, Aiba H et al (2000) J Neurovirol 6:121–126
Honarmand S, Glaser CA, Chow E et al (2004) Neurology 63:1489–1493
Hsu VP, Hossain MJ, Parashar UD et al (2004) Emerg Infect Dis 10:2082–2087
http://www.deephawaii.com/hawaiianhistory.htm. Accessed 5 Mar 2015
Huttenlocher PR, Mattson RH (1979) Neurology 29:764–771
Jabbour JT, Duenas DA, Sever JL et al (1972) J Am Med Assoc 220:959–962
Jardetsky TS, Lamb RA (2014) Curr Opin Virol 5:24–33
Johnson RT (1998) Viral infections of the nervous system, 2nd edn. Lippincott-Raven, New York
Jones CE, Huttenlocher PR, Dyken PR, et al. Lancet, May (1982) 1034-6
Katayama Y, Hotta H, Nishimura A et al (1995) J Gen Virol 76:3201–3204
Katayama Y, Kohso K, Nishimura A et al (1998) J Clin Microbiol 36:299–301
Kato Z, Saito K, Yamada M et al (2002) J Child Neurol 17:788–790
Kim MY, Ma Y, Zhang Y et al (2013) J Virol 87:10668–10678
Kirk J, Zhou AL, McQuaid S et al (1991) Neuropathol Appl Neurobiol 17:289–297
Krawiecki NS, Dyken PR, Gammal TE et al (1984) Ann Neurol 15:489–493
La Piana FG, Tso MO, Jenis EH (1974) Ann Ophthalmol 6:603–610
Lawrence DM, Vaughn MM, Belman AR et al (1999) J Virol 73:1795–1801
Lawrence DMP, Patterson CE, Gales TL et al (2000) J Virol 74:1908–1918
Legg NJ (1967) Br Med J 3:350–352
Lemon K, de Vries RD, Mesman AW et al (2011) PLoS Pathog 7:e1001263
Ludlow M, McQuaid S, Milner D et al (2015) J Pathol 235:253–265
Lum GB, Williams JP, Dyken PR et al (1986) Pediatr Neurol 2:75–79
Makhortova NR, Askovich P, Patterson CE et al (2007) Virology 362:235–244
Malik MA, Saeed M, Qureshi AU et al (2010) J Coll Physicians Surg Pak 20:671–674
Manie SN, Debreyne S, Vincent S, Gerlier D (2000) J Virol 74:305–311
Manning L, Laman M, Edoni H et al (2011) PLoS Negl Trop Dis 5:e932
McQuaid S, Cosby SL (2002) Lab Invest 82:403–409
Modlin JF, Halsey NA, Eddins DL et al (1979) J Pediatr 94:231–236
Moss WJ, Griffin DE (2006) Nat Rev Microbiol 4:900–908
Mühlebach MD, Mateo M, Sinn PL et al (2011) Nature 480:530–533
Murphy JV, Yunis EJ (1979) J Pediatr 88:937–942
Mustafa MM, Weitman SD, Winick NJ et al (1993) Clin Infect Dis 16:654–660
Naim HY, Ehler E, Billeter MA (2000) EMBO J 19:3576–3585
Nakayama T, Morit T, Yamaguchi S et al (1995) Virus Res 35:1–16
Naniche D, Varior-Krishnan G, Cervoni F et al (1993) J Virol 67:6025–6032
Noyce RS, Bondre DG, Ha MN et al (2011) PLoS Pathog 7:e1002240
Noyce RS, Delpeut S, Richardson CD (2013) Virology 436:210–220
Oldstone MB (2009) Curr Top Microbiol Immunol 330:31–54
Patterson CE, Lawrence DM, Echols LA, Rall GF (2002) J Virol 76:4497–4506
Payne FE, Baublis JV, Itabashi HH (1969) N Engl J Med 281:585–589
Poole E, He B, Lamb RA et al (2002) Virology 303:33–46
Prashanth LK, Taly AB, Ravi V et al (2006) Brain Dev 28:447–452
Risk WS, Haddad FS (1979) Arch Neurol 36:610–614
Rodriguez J, Wang LF, Horvath CM (2003) J Virol 77:11842–11847
Rosenblatt S, Koch T, Pinhasi O, Brasosin S (1979) J Virol 32:329–333
Rota PA, Brown K, Mankertz A et al (2011) J Infect Dis 204:S514–S523
Russell S (2004) Tissue Antigens 64:111–118
Sato K, Nakagawa E, Nonoda Y et al (2009) No To Hattatasu 41:224–228
Sawaishi Y, Yano T, Watanabe Y, Takada G (1999) J Neurol Sci 168:137–140
Schmid A, Spielhofer P, Cattaneo R et al (1992) Virology 188:910–915
Schönberger K, Ludwig MS, Wildner M, Weissbrich B (2013) PLoS One 8:e68909
Schrag SJ, Rota PA, Bellini WJ (1999) J Virol 73:51–54
Schubert S, Möller-Ehrlich K, Singethan K et al (2006) J Gen Virol 87:2011–2019
Shulman ST, Shulman DL, Sims RH (2009) Pediatr Infect Dis J 28:728–733
Silva CA, Paula-Barbosa MM, Pereira S et al (1981) Arch Neurol 38:109–113
Simone B, Balasgaram S, Gobin M et al (2014) Vaccine 32:4681–4688
Singer C, Lang AE, Suchowersky O (1977) Mov Disord 12:342–353
Solomon T, Hart CA, Vinjamurin S et al (2002) J Child Neurol 17:703–705
Sonia M, Lalit D, Shobha B et al (2009) J Commun Dis 41:161–167
Tatli B, Ekici B, Ozmen M (2012) Expert Rev Neurother 12:485–492
Tatsuo H, Yanagi Y (2000) Nature 406:893–897
Tishon A, Lewicki H, Andaya A et al (2006) Virology 347:234–245
Vincent S, Spehner D, Manie S et al (1999) Virology 265:185–195
Wong TC, Ayata M, Hirano A et al (1989) J Virol 63:5464–5468
World Health Organization. http://www.who.int/mediacentre/factsheets/fs286/en/. Accessed 5 Mar 2015
World Health Organization. http://www.who.int/vaccine_safety/committee/topics/measles_sspe/Jan_2006/en/. Accessed 5 Mar 2015
Yoshikawa Y, Tsuruoka H, Matsumoto M et al (1990) Virus Genes 4:151–161
Zilber N, Rannon L, Alter M et al (1983) Neurology 33:1558–1564
Zipprich J, Winter K, Hacker J et al (2015) MMWR Morb Mortal Wkly Rep 64:153–154
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Additional Resources
Additional Resources
National Institutes of Neurological Disorders and Stroke (NINDS)
http://www.ninds.nih.gov/disorders/subacute_panencephalitis/subacute_panencephalitis.htm
Centers for Disease Control and Prevention
http://www.cdc.gov/measles/about/complications.html
Isoprinosine®
Newport Pharmaceuticals Limited
Unit A4
Swords Enterprise Park
Feltrim Road, Swords
Co. Dublin
Ireland
Phone: + 353 1 516 4115
Fax: + 353 1 897 1773
Loc8 Code: NN9-55-3SJ
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
O’Donnell, L.A., Bale, J.F. (2016). Measles Virus and Subacute Sclerosing Panencephalitis. In: Reiss, C. (eds) Neurotropic Viral Infections. Springer, Cham. https://doi.org/10.1007/978-3-319-33133-1_2
Download citation
DOI: https://doi.org/10.1007/978-3-319-33133-1_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-33131-7
Online ISBN: 978-3-319-33133-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)