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Neurotropic Viral Infections pp 337–360Cite as

Reovirus

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Abstract

Mammalian orthoreoviruses are nonenveloped dsRNA viruses that infect most mammals including humans and mice. Following oral inoculation of newborn mice, reovirus disseminates to the CNS and produces a nonlethal hydrocephalus or a lethal encephalitis, depending on the virus strain. This strain-dependent manifestation of reovirus disease coupled with the availability of a reverse genetics system has enabled the identification of virus and host determinants of reovirus neuropathogenesis and elucidated mechanisms of reovirus receptor binding, internalization, uncoating, cell injury, dissemination, and disease. This chapter will describe key features of reovirus neuropathogenesis and provide perspectives for future research.

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Authors and Affiliations

  1. Department of Pediatrics, Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, 1161 21st Ave. S., Nashville, TN, 37232, USA

    Andrea J. Pruijssers

  2. Departments of Pediatrics, Pathology, Microbiology, and Immunology, Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, 1161 21st Ave. S., Nashville, TN, 37232, USA

    Terence S. Dermody

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Correspondence to Andrea J. Pruijssers .

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  1. Departments of Biology and Neural Science, New York University, New York, New York, USA

    Carol Shoshkes Reiss

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Pruijssers, A.J., Dermody, T.S. (2016). Reovirus. In: Reiss, C. (eds) Neurotropic Viral Infections. Springer, Cham. https://doi.org/10.1007/978-3-319-33133-1_14

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