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Borna Disease Virus

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Neurotropic Viral Infections

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Abstract

The neurotropic virus, Borna disease virus (BDV), a member of a group of nonsegmented, negative strand ribonucleic acid (RNA) viruses (order Mononegavirales), infects warm-blooded animal species. Infection among mammals may be asymptomatic, produce neurobehavioral abnormalities, or result in fatal meningoencephalitis. It is unique among animal viruses in the order Mononegavirales in its nuclear localization of replication and transcription and distinctive in its capacity to establish persistent, non-cytolytic infection of the peripheral and central nervous systems. Natural infection, long described in horses and sheep, has more recently been recognized to extend to bird species in association with a related virus, avian bornavirus, as well as to divergent bornaviruses in reptiles, challenging established virus taxonomy. Nonhuman primates can be experimentally infected; however, natural infection of humans and nonhuman primates appears to be unusual. Decades-long controversy over a role for BDV infection in human neuropsychiatric illnesses has more recently waned. Nonetheless, the discovery that the genomes of humans as well as other vertebrate lineages contain remnants of BDV sequences has raised questions regarding potential evolutionary implications. Analysis of rodent models of infection has yielded insights into the mechanisms by which neurotropic agents and host immune and signaling pathway responses may impact upon developing or mature CNS circuitry to effect complex neurobehavioral disturbances.

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References

  • Altshuler LL, Conrad A, Kovelman JA, Scheibel A (1987) Hippocampal pyramidal cell orientation in schizophrenia: a controlled neurohistologic study of the Yakovlev Collection. Arch Gen Psychiatry 44:1094–1098

    Article  CAS  PubMed  Google Scholar 

  • Amsterdam JD, Winokur A, Dyson W, Herzog S, Gonzalez F, Rott R, Koprowski H (1985) Borna disease virus. A possible etiologic factor in human affective disorders? Arch Gen Psychiatry 42(11):1093–1096

    Article  CAS  PubMed  Google Scholar 

  • Anderson GM (1994) Studies on the neurochemistry of autism. In: Bauman ML, Kemper TL (eds) The neurobiology of autism. Johns Hopkins University Press, Baltimore, pp 227–242

    Google Scholar 

  • Bahmani MK, Nowrouzian I, Nakaya T, Nakamura Y, Hagiwara K, Takahashi H, Rad MA, Ikuta K (1996) Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran. Virus Res 45(1):1–13

    Article  CAS  PubMed  Google Scholar 

  • Bajramovic JJ, Syan S, Brahic M, de la Torre JC, Gonzalez-Dunia D (2002) 1-beta-D-arabinofuranosylcytosine inhibits borna disease virus replication and spread. J Virol 76(12):6268–6276

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bautista JR, Schwartz GJ, de la Torre JC, Moran TH, Carbone KM (1994) Early and persistent abnormalities in rats with neonatally acquired Borna disease virus infection. Brain Res Bull 34(1):31–40

    Article  CAS  PubMed  Google Scholar 

  • Bautista JR, Rubin SA, Moran TH, Schwartz GJ, Carbone KM (1995) Developmental injury to the cerebellum following perinatal Borna disease virus infection. Brain Res Dev Brain Res 90(1–2):45–53

    Article  CAS  PubMed  Google Scholar 

  • Beck A, Frohböse H (1926) Die enzootische Encephalitis des Schafes. Arch Wiss Prakt Tierheilkd 54:84–110

    Google Scholar 

  • Belyi VA, Levine AJ, Skalka AM (2010) Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. PLoS Pathog 6(7):e1001030. doi:10.1371/journal.ppat.1001030

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Berg M, Johansson M, Montell H, Berg AL (2001) Wild birds as a possible natural reservoir of Borna disease virus. Epidemiol Infect 127(1):173–178

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Binz T, Lebelt J, Niemann H, Hagenau K (1994) Sequence analyses of the p24 gene of Borna disease virus in naturally infected horse, donkey and sheep. Virus Res 34(3):281–289

    Article  CAS  PubMed  Google Scholar 

  • Bode L, Dietrich DE, Stoyloff R, Emrich HM, Ludwig H (1997) Amantadine and human Borna disease virus in vitro and in vivo in an infected patient with bipolar depression. Lancet 349(9046):178–179. doi:10.1016/S0140-6736(05)60979-8

    Article  CAS  PubMed  Google Scholar 

  • Bode L, Reckwald P, Severus WE, Stoyloff R, Ferszt R, Dietrich DE, Ludwig H (2001) Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies—the key marker triplet determining infection and prevailing in severe mood disorders. Mol Psychiatry 6(4):481–491. doi:10.1038/sj.mp.4000909

    Article  CAS  PubMed  Google Scholar 

  • Bonnaud EM, Szelechowski M, Betourne A, Foret C, Thouard A, Gonzalez-Dunia D, Malnou CE (2015) Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. J Virol 89(11):5996–6008. doi:10.1128/JVI.00454-15

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bourg M, Herzog S, Encarnacao JA, Nobach D, Lange-Herbst H, Eickmann M, Herden C (2013) Bicolored white-toothed shrews as reservoir for borna disease virus, Bavaria, Germany. Emerg Infect Dis 19(12):2064–2066. doi:10.3201/eid1912.131076

    Article  PubMed  PubMed Central  Google Scholar 

  • Briese T, de la Torre JC, Lewis A, Ludwig H, Lipkin WI (1992) Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells. Proc Natl Acad Sci U S A 89(23):11486–11489

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Briese T, Schneemann A, Lewis AJ, Park YS, Kim S, Ludwig H, Lipkin WI (1994) Genomic organization of Borna disease virus. Proc Natl Acad Sci U S A 91(10):4362–4366

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Caplazi P, Waldvogel A, Stitz L, Braun U, Ehrensperger F (1994) Borna disease in naturally infected cattle. J Comp Pathol 111:62–72

    Article  Google Scholar 

  • Carbone KM, Park SW, Rubin SA, Waltrip RW 2nd, Vogelsang GB (1991) Borna disease: association with a maturation defect in the cellular immune response. J Virol 65(11):6154–6164

    CAS  PubMed  PubMed Central  Google Scholar 

  • Clemente R, de la Torre JC (2007) Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated processing of the virus surface glycoprotein. J Virol 81(11):5968–5977. doi:10.1128/JVI.02426-06

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cubitt B, de la Torre JC (1994) Borna disease virus (BDV), a nonsegmented RNA virus, replicates in the nuclei of infected cells where infectious BDV ribonucleoproteins are present. J Virol 68(3):1371–1381

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cubitt B, de la Torre JC (1997) Amantadine does not have antiviral activity against Borna disease virus. Arch Virol 142(10):2035–2042

    Article  CAS  PubMed  Google Scholar 

  • Danner K, Mayr A (1973) Fluorescence serological studies on the appearance of Borna virus antigen in cell cultures from brain explants of infected rabbits. Zentralbl Veterinarmed B 20(7):497–508

    Article  CAS  PubMed  Google Scholar 

  • Danner K, Heubeck D, Mayr A (1978) In vitro studies on Borna virus. I. The use of cell cultures for the demonstration, titration and production of Borna virus. Arch Virol 57(1):63–75

    Article  CAS  PubMed  Google Scholar 

  • Dauphin G, Legay V, Sailleau C, Smondack S, Hammoumi S, Zientara S (2001) Evidence of Borna disease virus genome detection in French domestic animals and in foxes (Vulpes vulpes). J Gen Virol 82(Pt 9):2199–2204

    Article  CAS  PubMed  Google Scholar 

  • de la Torre JC (1994) Molecular biology of borna disease virus: prototype of a new group of animal viruses. J Virol 68(12):7669–7675

    PubMed  PubMed Central  Google Scholar 

  • Degiorgis MP, Berg AL, Hard Af Segerstad C, Morner T, Johansson M, Berg M (2000) Borna disease in a free-ranging lynx (Lynx lynx). J Clin Microbiol 38(8):3087–3091

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dietrich DE, Bode L, Spannhuth CW, Lau T, Huber TJ, Brodhun B, Ludwig H, Emrich HM (2000) Amantadine in depressive patients with Borna disease virus (BDV) infection: an open trial. Bipolar Disord 2(1):65–70

    Article  CAS  PubMed  Google Scholar 

  • Dittrich W, Bode L, Ludwig H, Kao M, Schneider K (1989) Learning deficiencies in Borna disease virus-infected but clinically healthy rats. Biol Psychiatry 26(8):818–828

    Article  CAS  PubMed  Google Scholar 

  • Durrwald R, Kolodziejek J, Herzog S, Nowotny N (2007) Meta-analysis of putative human bornavirus sequences fails to provide evidence implicating Borna disease virus in mental illness. Rev Med Virol 17(3):181–203. doi:10.1002/rmv.530

    Article  PubMed  CAS  Google Scholar 

  • Durrwald R, Kolodziejek J, Weissenbock H, Nowotny N (2014) The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virus. PLoS One 9(4):e93659. doi:10.1371/journal.pone.0093659

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Eisenman LM, Brother R, Tran MH, Kean RB, Dickson GM, Dietzschold B, Hooper DC (1999) Neonatal Borna disease virus infection in the rat causes a loss of Purkinje cells in the cerebellum. J Neurovirol 5:181–189

    Article  CAS  PubMed  Google Scholar 

  • Encarnacao JA, Herzog S, Eickmann M, Becker NI, Hermes N, Herden C (2013) Landscape features and reservoir occurrence affecting the risk for equine infection with Borna disease virus. J Wildl Dis 49(4):860–868. doi:10.7589/2012-10-262

    Article  PubMed  Google Scholar 

  • Ernst M, Zametkin AJ, Matochik JA, Pascualvaca D, Cohen RM (1997) Low medial prefrontal dopaminergic activity in autistic children. Lancet 350:638

    Article  CAS  PubMed  Google Scholar 

  • Ferszt R, Kuhl KP, Bode L, Severus EW, Winzer B, Berghofer A, Beelitz G, Brodhun B, Muller-Oerlinghausen B, Ludwig H (1999) Amantadine revisited: an open trial of amantadinesulfate treatment in chronically depressed patients with Borna disease virus infection. Pharmacopsychiatry 32(4):142–147. doi:10.1055/s-2007-979220

    Article  CAS  PubMed  Google Scholar 

  • Fish B, Marcus J, Hans SL, Auerbach JG, Perdue S (1992) Infants at risk for schizophrenia: sequelae of a genetic neurointegrative defect: a review and replication analysis of pandysmaturation in the Jerusalem Infant Development Study. Arch Gen Psychiatry 49:221–235

    Article  CAS  PubMed  Google Scholar 

  • Fujino K, Horie M, Honda T, Merriman DK, Tomonaga K (2014) Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome. Proc Natl Acad Sci U S A 111(36):13175–13180. doi:10.1073/pnas.1407046111

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Galabru J, Saron MF, Berg M, Berg AL, Herzog S, Labie J, Zientara S (2000) Borna disease virus antibodies in French horses. Vet Rec 147(25):721–722

    CAS  PubMed  Google Scholar 

  • Gellert M (1995) “In the beginning the horse is sad”—a historical abstract of Borna disease. Tierarztl Prax 23(3):207–216

    CAS  PubMed  Google Scholar 

  • Gensert E (1896) Die Borna’sche Krankheit. Berl Thierärztl Wochenschr 12:447–449

    Google Scholar 

  • Gies U, Gorcs TJ, Mulder J, Planz O, Stitz L, Bilzer T, Luiten PG, Harkany T (2001) Cortical cholinergic decline parallels the progression of Borna virus encephalitis. Neuroreport 12(17):3767–3772

    Article  CAS  PubMed  Google Scholar 

  • Gosztonyi G, Dietzschold B, Kao M, Rupprecht CE, Koprowski H (1993) Rabies virus and Borna disease-a comparative pathogenic study of two neurovirulent agents. Lab Invest 68:285–295

    CAS  PubMed  Google Scholar 

  • Gregory CR, Latimer KS, Niagro FD, Ritchie BW, Campagnoli RP, Norton TM, McManamon R, Greenacre CB (1994) A review of proventricular dilatation syndrome. J Assoc Avian Vet 8(2):69–75

    Article  Google Scholar 

  • Haga S, Yoshimura M, Motoi Y, Arima K, Aizawa T, Ikuta K, Tashiro M, Ikeda K (1997) Detection of Borna disease virus genome in normal human brain tissue. Brain Res 770(1–2):307–309

    Article  CAS  PubMed  Google Scholar 

  • Hagiwara K, Nakaya T, Nakamura Y, Asahi S, Takahashi H, Ishihara C, Ikuta K (1996) Borna disease virus RNA in peripheral blood mononuclear cells obtained from healthy dairy cattle. Med Microbiol Immunol (Berl) 185(3):145–151

    Article  CAS  Google Scholar 

  • Hagiwara K, Kawamoto S, Takahashi H, Nakamura Y, Nakaya T, Hiramune T, Ishihara C, Ikuta K (1997a) High prevalence of Borna disease virus infection in healthy sheep in Japan. Clin Diagn Lab Immunol 4(3):339–344

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hagiwara K, Momiyama N, Taniyama H, Nakaya T, Tsunoda N, Ishihara C, Ikuta K (1997b) Demonstration of Borna disease virus (BDV) in specific regions of the brain from horses positive for serum antibodies to BDV but negative for BDV RNA in the blood and internal organs. Med Microbiol Immunol (Berl) 186(1):19–24

    Article  CAS  Google Scholar 

  • Hagiwara K, Kamitani W, Takamura S, Taniyama H, Nakaya T, Tanaka H, Kirisawa R, Iwai H, Ikuta K (2000) Detection of Borna disease virus in a pregnant mare and her fetus. Vet Microbiol 72(3–4):207–216

    Article  CAS  PubMed  Google Scholar 

  • Hagiwara K, Asakawa M, Liao L, Jiang W, Yan S, Chai J, Oku Y, Ikuta K, Ito M (2001) Seroprevalence of Borna disease virus in domestic animals in Xinjiang, China. Vet Microbiol 80(4):383–389

    Article  CAS  PubMed  Google Scholar 

  • Hallensleben W, Zocher M, Staeheli P (1997) Borna disease virus is not sensitive to amantadine. Arch Virol 142(10):2043–2048

    Article  CAS  PubMed  Google Scholar 

  • Hans A, Syan S, Crosio C, Sassone-Corsi P, Brahic M, Gonzalez-Dunia D (2001) Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells. J Biol Chem 276(10):7258–7265. doi:10.1074/jbc.M005107200

    Article  CAS  PubMed  Google Scholar 

  • Hatalski CG, Lewis AJ, Lipkin WI (1997) Borna disease. Emerg Infect Dis 3(2):129–135. doi:10.3201/eid0302.970205

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heffels-Redmann U, Enderlein D, Herzog S, Herden C, Piepenbring A, Neumann D, Muller H, Capelli S, Muller H, Oberhauser K, Gerlach H, Kaleta EF, Lierz M (2011) Occurrence of avian bornavirus infection in captive psittacines in various European countries and its association with proventricular dilatation disease. Avian Pathol 40(4):419–426. doi:10.1080/03079457.2011.589825

    Article  PubMed  Google Scholar 

  • Heimrich B, Hesse DA, Wu YJ, Schmid S, Schwemmle M (2009) Borna disease virus infection alters synaptic input of neurons in rat dentate gyrus. Cell Tissue Res 338(2):179–190. doi:10.1007/s00441-009-0875-x

    Article  PubMed  Google Scholar 

  • Helps CR, Turan N, Bilal T, Harbour DA, Yilmaz H (2001) Detection of antibodies to Borna disease virus in Turkish cats by using recombinant p40. Vet Rec 149(21):647–650

    Article  CAS  PubMed  Google Scholar 

  • Herzog S, Rott R (1980) Replication of Borna disease virus in cell cultures. Med Microbiol Immunol 168:153–158

    Article  CAS  PubMed  Google Scholar 

  • Hirano N, Kao M, Ludwig H (1983) Persistent, tolerant or subacute infection in Borna disease virus-infected rats. J Gen Virol 64(Pt 7):1521–1530

    Article  PubMed  Google Scholar 

  • Hoffmann B, Tappe D, Hoper D, Herden C, Boldt A, Mawrin C, Niederstrasser O, Muller T, Jenckel M, van der Grinten E, Lutter C, Abendroth B, Teifke JP, Cadar D, Schmidt-Chanasit J, Ulrich RG, Beer M (2015) A variegated squirrel bornavirus associated with fatal human encephalitis. N Engl J Med 373(2):154–162. doi:10.1056/NEJMoa1415627

    Article  CAS  PubMed  Google Scholar 

  • Honkavuori KS, Shivaprasad HL, Williams BL, Quan PL, Hornig M, Street C, Palacios G, Hutchison SK, Franca M, Egholm M, Briese T, Lipkin WI (2008) Novel borna virus in psittacine birds with proventricular dilatation disease. Emerg Infect Dis 14(12):1883–1886. doi:10.3201/eid1412.080984

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Horie M, Honda T, Suzuki Y, Kobayashi Y, Daito T, Oshida T, Ikuta K, Jern P, Gojobori T, Coffin JM, Tomonaga K (2010) Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature 463(7277):84–87. doi:10.1038/nature08695

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Horii Y, Garcia NP, Noviana D, Kono F, Sawada T, Naraki T, Yamaguchi K (2001) Detection of anti-borna disease virus antibodies from cats in Asian countries, Japan, Philippines and Indonesia using electrochemiluminescence immunoassay. J Vet Med Sci 63(8):921–923

    Article  CAS  PubMed  Google Scholar 

  • Hornig M, Weissenbock H, Horscroft N, Lipkin WI (1999) An infection-based model of neurodevelopmental damage. Proc Natl Acad Sci U S A 96(21):12102–12107

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hornig M, Briese T, Lipkin WI (2001) Bornavirus tropism and targeted pathogenesis: virus-host interactions in a neurodevelopmental model. Adv Virus Res 56:557–582

    Article  CAS  PubMed  Google Scholar 

  • Hornig M, Briese T, Lipkin WI (2003) Borna disease virus. J Neurovirol 9(2):259–273. doi:10.1080/13550280390194064

    Article  CAS  PubMed  Google Scholar 

  • Hornig M, Briese T, Licinio J, Khabbaz RF, Altshuler LL, Potkin SG, Schwemmle M, Siemetzki U, Mintz J, Honkavuori K, Kraemer HC, Egan MF, Whybrow PC, Bunney WE, Lipkin WI (2012) Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder. Mol Psychiatry 17(5):486–493. doi:10.1038/mp.2011.179

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Joest E, Degen K (1909) Über eigentümliche Kerneinschlüsse der Ganglienzellen bei der enzootischen Gehirn-Rückenmarksentzündung der Pferde. Z Infkrankh Haustiere 6:348–356

    Google Scholar 

  • Jordan I, Lipkin WI (2001) Borna disease virus. Rev Med Virol 11(1):37–57

    Article  CAS  PubMed  Google Scholar 

  • Kamitani W, Shoya Y, Kobayashi T, Watanabe M, Lee BJ, Zhang G, Tomonaga K, Ikuta K (2001) Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1. J Virol 75(18):8742–8751

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kamitani W, Ono E, Yoshino S, Kobayashi T, Taharaguchi S, Lee BJ, Yamashita M, Kobayashi T, Okamoto M, Taniyama H, Tomonaga K, Ikuta K (2003) Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice. Proc Natl Acad Sci U S A 100(15):8969–8974. doi:10.1073/pnas.1531155100

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kao M, Ludwig H, Gosztonyi G (1984) Adaptation of Borna disease virus to the mouse. J Gen Virol 65(Pt 10):1845–1849

    Article  PubMed  Google Scholar 

  • Kao M, Hamir AN, Rupprecht CE, Fu ZF, Shankar V, Koprowski H, Dietzschold B (1993) Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA. Vet Rec 132(10):241–244

    Article  CAS  PubMed  Google Scholar 

  • Kelsoe JR, Savodnick AD, Kristbjarnarson H, Bergesch P, Mroczkowski-Parker Z, Drennan M, Rapaport MH, Flodman P, Spence MA, Remick RA (1996) Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. Am J Med Genet 67:533–540

    Article  CAS  PubMed  Google Scholar 

  • Kemper TL, Bauman ML (1993) The contribution of neuropathologic studies to the understanding of autism. Neurol Clin North Am 11:175–187

    CAS  Google Scholar 

  • Kilbourne ED (1991) New viruses and new disease: mutation, evolution and ecology. Curr Opin Immunol 3(4):518–524

    Article  CAS  PubMed  Google Scholar 

  • Kishi M, Nakaya T, Nakamura Y, Zhong Q, Ikeda K, Senjo M, Kakinuma M, Kato S, Ikuta K (1995) Demonstration of human Borna disease virus RNA in human peripheral blood mononuclear cells. FEBS Lett 364(3):293–297

    Article  CAS  PubMed  Google Scholar 

  • Kistler AL, Gancz A, Clubb S, Skewes-Cox P, Fischer K, Sorber K, Chiu CY, Lublin A, Mechani S, Farnoushi Y, Greninger A, Wen CC, Karlene SB, Ganem D, DeRisi JL (2008) Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent. Virol J 5:88. doi:10.1186/1743-422X-5-88

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kuhn JH, Durrwald R, Bao Y, Briese T, Carbone K, Clawson AN, deRisi JL, Garten W, Jahrling PB, Kolodziejek J, Rubbenstroth D, Schwemmle M, Stenglein M, Tomonaga K, Weissenbock H, Nowotny N (2015) Taxonomic reorganization of the family Bornaviridae. Arch Virol 160(2):621–632. doi:10.1007/s00705-014-2276-z

    Article  CAS  PubMed  Google Scholar 

  • Lierz M, Hafez HM, Honkavuori KS, Gruber AD, Olias P, Abdelwhab EM, Kohls A, Lipkin WI, Briese T, Hauck R (2009) Anatomical distribution of avian bornavirus in parrots, its occurrence in clinically healthy birds and ABV-antibody detection. Avian Pathol 38(6):491–496. doi:10.1080/03079450903349238

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lipkin WI, Hornig M (2015) Diagnostics and discovery in viral central nervous system infections. Brain Pathol 25(5):600–604. doi:10.1111/bpa.12277

    Article  PubMed  Google Scholar 

  • Lipkin WI, Carbone KM, Wilson MC, Duchala CS, Narayan O, Oldstone MB (1988) Neurotransmitter abnormalities in Borna disease. Brain Res 475(2):366–370

    Article  CAS  PubMed  Google Scholar 

  • Lipkin WI, Travis GH, Carbone KM, Wilson MC (1990) Isolation and characterization of Borna disease agent cDNA clones. Proc Natl Acad Sci U S A 87(11):4184–4188

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lipkin WI, Hornig M, Briese T (2001) Borna disease virus and neuropsychiatric disease—a reappraisal. Trends Microbiol 9(7):295–298

    Article  CAS  PubMed  Google Scholar 

  • Lipkin WI, Briese T, Hornig M (2011) Borna disease virus—fact and fantasy. Virus Res 162(1-2):162–172. doi:10.1016/j.virusres.2011.09.036

    Article  CAS  PubMed  Google Scholar 

  • Liu S, Bode L, Zhang L, He P, Huang R, Sun L, Chen S, Zhang H, Guo Y, Zhou J, Fu Y, Zhu D, Xie P (2015) GC-MS-based metabonomic profiling displayed differing effects of borna disease virus natural strain Hu-H1 and laboratory strain V infection in rat cortical neurons. Int J Mol Sci 16(8):19347–19368. doi:10.3390/ijms160819347

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ludwig H, Bode L (1997) The neuropathogenesis of Borna disease virus infections. Intervirology 40(2–3):185–197

    Article  CAS  PubMed  Google Scholar 

  • Ludwig TH, Becht H, Groh L (1973) Borna disease (BD), a slow virus infection. Biological properties of the virus. Med Microbiol Immunol 158(4):275–289

    Article  CAS  PubMed  Google Scholar 

  • Ludwig H, Koester V, Pauli G, Rott R (1977) The cerebrospinal fluid of rabbits infected with Borna disease virus. Arch Virol 55(3):209–223

    Article  CAS  PubMed  Google Scholar 

  • Ludwig H, Bode L, Gosztonyi G (1988) Borna disease: a persistent virus infection of the central nervous system. Prog Med Virol 35:107–151

    CAS  PubMed  Google Scholar 

  • Lundgren AL, Czech G, Bode L, Ludwig H (1993) Natural Borna disease in domestic animals others than horses and sheep. Zentralbl Veterinarmed B 40(4):298–303

    CAS  PubMed  Google Scholar 

  • Lutz H, Addie DD, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Horzinek MC, Hosie MJ, Lloret A, Marsilio F, Pennisi MG, Radford AD, Thiry E, Truyen U, Mostl K, European Advisory Board on Cat D (2015) Borna disease virus infection in cats: ABCD guidelines on prevention and management. J Feline Med Surg 17(7):614–616. doi:10.1177/1098612X15588452

    Article  PubMed  Google Scholar 

  • Malkinson M, Weisman Y, Ashash E, Bode L, Ludwig H (1993) Borna disease in ostriches [letter; comment]. Vet Rec 133(12):304

    Article  CAS  PubMed  Google Scholar 

  • Mayr A, Danner K (1972) Production of Borna virus in tissue culture. Proc Soc Exp Biol Med 140:511–515

    Article  CAS  PubMed  Google Scholar 

  • Mayr A, Danner K (1974) Züchtung und Titrierung von Borna-Virus in Zellkulturen aus Organen fötaler Lämmer. Zentralbl Veterinarmed B 21(3):131–137

    Article  CAS  PubMed  Google Scholar 

  • Nakamura Y, Kishi M, Nakaya T, Asahi S, Tanaka H, Sentsui H, Ikeda K, Ikuta K (1995) Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells from healthy horses in Japan. Vaccine 13(12):1076–1079

    Article  CAS  PubMed  Google Scholar 

  • Nakamura Y, Asahi S, Nakaya T, Bahmani MK, Saitoh S, Yasui K, Mayama H, Hagiwara K, Ishihara C, Ikuta K (1996) Demonstration of borna disease virus RNA in peripheral blood mononuclear cells derived from domestic cats in Japan. J Clin Microbiol 34(1):188–191

    CAS  PubMed  PubMed Central  Google Scholar 

  • Nakamura Y, Watanabe M, Kamitani W, Taniyama H, Nakaya T, Nishimura Y, Tsujimoto H, Machida S, Ikuta K (1999) High prevalence of Borna disease virus in domestic cats with neurological disorders in Japan. Vet Microbiol 70(3–4):153–169

    Article  CAS  PubMed  Google Scholar 

  • Nakamura Y, Takahashi H, Shoya Y, Nakaya T, Watanabe M, Tomonaga K, Iwahashi K, Ameno K, Momiyama N, Taniyama H, Sata T, Kurata T, de la Torre JC, Ikuta K (2000) Isolation of Borna disease virus from human brain tissue. J Virol 74(10):4601–4611

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Narayan O, Herzog S, Frese K, Scheefers H, Rott R (1983a) Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain. Science 220(4604):1401–1403

    Article  CAS  PubMed  Google Scholar 

  • Narayan O, Herzog S, Frese K, Scheefers H, Rott R (1983b) Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. J Infect Dis 148(2):305–315

    Article  CAS  PubMed  Google Scholar 

  • Nicolau S, Galloway IA (1928) Borna disease and enzootic encephalo-myelitis of sheep and cattle. Spec Rep Ser. 121:7–90. H. M. Stat Office, London

    Google Scholar 

  • Nishino Y, Kobasa D, Rubin SA, Pletnikov MV, Carbone KM (2002) Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes. J Virol 76(17):8650–8658

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nobach D, Bourg M, Herzog S, Lange-Herbst H, Encarnacao JA, Eickmann M, Herden C (2015) Shedding of infectious Borna disease virus-1 in living bicolored white-toothed shrews. PLoS One 10(8):e0137018. doi:10.1371/journal.pone.0137018

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nowotny N, Kolodziejek J, Jehle CO, Suchy A, Staeheli P, Schwemmle M (2000) Isolation and characterization of a new subtype of Borna disease virus. J Virol 74(12):5655–5658

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ogawa H, Sanada Y, Sanada N, Kudo M, Tuchiya K, Kodama T, Uetsuka K (2011) Proventricular dilatation disease associated with avian bornavirus infection in a Citron-crested Cockatoo that was born and hand-reared in Japan. J Vet Med Sci 73(6):837–840

    Article  PubMed  Google Scholar 

  • Okamoto M, Kagawa Y, Kamitani W, Hagiwara K, Kirisawa R, Iwai H, Ikuta K, Taniyama H (2002) Borna disease in a dog in Japan. J Comp Pathol 126(4):312–317

    Article  CAS  PubMed  Google Scholar 

  • Ovanesov MV, Moldovan K, Smith K, Vogel MW, Pletnikov MV (2008) Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus. J Neuroinflammation 5:16. doi:10.1186/1742-2094-5-16

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Partonen T (1996) Dopamine and circadian rhythms in seasonal affective disorder. Proc Soc Exp Biol Med 47:191–192

    CAS  Google Scholar 

  • Peng G, Yan Y, Zhu C, Wang S, Yan X, Lu L, Li W, Hu J, Wei W, Mu Y, Chen Y, Feng Y, Gong R, Wu K, Zhang F, Zhang X, Zhu Y, Wu J (2008) Borna disease virus P protein affects neural transmission through interactions with gamma-aminobutyric acid receptor-associated protein. J Virol 82(24):12487–12497. doi:10.1128/JVI.00877-08

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pette H, Környey S (1935) Über die Pathogenese und die Histologie der Bornaschen Krankheit im Tierexperiment. Dtsch Z Nervenheilkd 136:20–63

    Article  Google Scholar 

  • Planz O, Rentzsch C, Batra A, Winkler T, Buttner M, Rziha HJ, Stitz L (1999) Pathogenesis of borna disease virus: granulocyte fractions of psychiatric patients harbor infectious virus in the absence of antiviral antibodies. J Virol 73(8):6251–6256

    CAS  PubMed  PubMed Central  Google Scholar 

  • Planz O, Pleschka S, Ludwig S (2001) MEK-specific inhibitor U0126 blocks spread of Borna disease virus in cultured cells. J Virol 75(10):4871–4877. doi:10.1128/JVI.75.10.4871-4877.2001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pleschka S, Staeheli P, Kolodziejek J, Richt JA, Nowotny N, Schwemmle M (2001) Conservation of coding potential and terminal sequences in four different isolates of Borna disease virus. J Gen Virol 82(Pt 11):2681–2690

    Article  CAS  PubMed  Google Scholar 

  • Pletnikov MV, Rubin SA, Schwartz GJ, Moran TH, Sobotka TJ, Carbone KM (1999a) Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats. Physiol Behav 66(5):823–831

    Article  CAS  PubMed  Google Scholar 

  • Pletnikov MV, Rubin SA, Vasudevan K, Moran TH, Carbone KM (1999b) Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism. Behav Brain Res 100(1–2):43–50

    Article  CAS  PubMed  Google Scholar 

  • Pletnikov MV, Rubin SA, Carbone KM, Moran TH, Schwartz GJ (2001) Neonatal Borna disease virus infection (BDV)-induced damage to the cerebellum is associated with sensorimotor deficits in developing Lewis rats. Brain Res Dev Brain Res 126:1–12

    Article  CAS  PubMed  Google Scholar 

  • Prat CM, Schmid S, Farrugia F, Cenac N, Le Masson G, Schwemmle M, Gonzalez-Dunia D (2009) Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity. PLoS Pathog 5(5):e1000425. doi:10.1371/journal.ppat.1000425

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pringle CR (1997) The order mononegavirales—current status. Arch Virol 142(11):2321–2326

    CAS  PubMed  Google Scholar 

  • Puorger ME, Hilbe M, Muller JP, Kolodziejek J, Nowotny N, Zlinszky K, Ehrensperger F (2010) Distribution of Borna disease virus antigen and RNA in tissues of naturally infected bicolored white-toothed shrews, Crocidura leucodon, supporting their role as reservoir host species. Vet Pathol 47(2):236–244. doi:10.1177/0300985809351849

    Article  CAS  PubMed  Google Scholar 

  • Rauer M, Pagenstecher A, Schulte-Monting J, Sauder C (2002) Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation. J Neurovirol 8:168–179

    Article  CAS  PubMed  Google Scholar 

  • Reeves NA, Helps CR, Gunn-Moore DA, Blundell C, Finnemore PL, Pearson GR, Harbour DA (1998) Natural Borna disease virus infection in cats in the United Kingdom. Vet Rec 143(19):523–526

    Article  CAS  PubMed  Google Scholar 

  • Rinder M, Ackermann A, Kempf H, Kaspers B, Korbel R, Staeheli P (2009) Broad tissue and cell tropism of avian bornavirus in parrots with proventricular dilatation disease. J Virol 83(11):5401–5407. doi:10.1128/JVI.00133-09

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rott R, Herzog S, Fleischer B, Winokur A, Amsterdam J, Dyson W, Koprowski H (1985) Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science 228(4700):755–756

    Article  CAS  PubMed  Google Scholar 

  • Rubin SA, Sierra-Honigmann AM, Lederman HM, Waltrip RW 2nd, Eiden JJ, Carbone KM (1995) Hematologic consequences of Borna disease virus infection of rat bone marrow and thymus stromal cells. Blood 85(10):2762–2769

    CAS  PubMed  Google Scholar 

  • Rubin SA, Sylves P, Vogel M, Pletnikov M, Moran TH, Schwartz GJ, Carbone KM (1999) Borna disease virus-induced hippocampal dentate gyrus damage is associated with spatial learning and memory deficits. Brain Res Bull 48(1):23–30

    Article  CAS  PubMed  Google Scholar 

  • Salvatore M, Morzunov S, Schwemmle M, Lipkin WI (1997) Borna disease virus in brains of North American and European people with schizophrenia and bipolar disorder. Bornavirus Study Group. Lancet 349(9068):1813–1814

    Article  CAS  PubMed  Google Scholar 

  • Sauder C, de la Torre JC (1999) Cytokine expression in the rat central nervous system following perinatal Borna disease virus infection. J Neuroimmunol 96(1):29–45

    Article  CAS  PubMed  Google Scholar 

  • Sauder C, Hallensleben W, Pagenstecher A, Schneckenburger S, Biro L, Pertlik D, Hausmann J, Suter M, Staeheli P (2000) Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation. J Virol 74(19):9267–9280

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schneemann A, Schneider PA, Kim S, Lipkin WI (1994) Identification of signal sequences that control transcription of borna disease virus, a nonsegmented, negative-strand RNA virus. J Virol 68(10):6514–6522

    CAS  PubMed  PubMed Central  Google Scholar 

  • Schneemann A, Schneider PA, Lamb RA, Lipkin WI (1995a) The remarkable coding strategy of borna disease virus: a new member of the nonsegmented negative strand RNA viruses. Virology 210(1):1–8. doi:10.1006/viro.1995.1311

    Article  CAS  PubMed  Google Scholar 

  • Schneemann A, Schneider PA, Lipkin WI (1995b) The atypical strategies used for gene expression of Borna disease virus, a nonsegmented, negative-strand RNA virus. Uirusu 45(2):165–174

    Article  CAS  PubMed  Google Scholar 

  • Schneider PA, Briese T, Zimmermann W, Ludwig H, Lipkin WI (1994a) Sequence conservation in field and experimental isolates of Borna disease virus. J Virol 68(1):63–68

    CAS  PubMed  PubMed Central  Google Scholar 

  • Schneider PA, Schneemann A, Lipkin WI (1994b) RNA splicing in Borna disease virus, a nonsegmented, negative-strand RNA virus. J Virol 68(8):5007–5012

    CAS  PubMed  PubMed Central  Google Scholar 

  • Schwemmle M, De B, Shi L, Banerjee A, Lipkin WI (1997) Borna disease virus P-protein is phosphorylated by protein kinase Cepsilon and casein kinase II. J Biol Chem 272(35):21818–21823

    Article  CAS  PubMed  Google Scholar 

  • Schwemmle M, Jehle C, Formella S, Staeheli P (1999a) Sequence similarities between human bornavirus isolates and laboratory strains question human origin. Lancet 354(9194):1973–1974

    Article  CAS  PubMed  Google Scholar 

  • Schwemmle M, Jehle C, Shoemaker T, Lipkin WI (1999b) Characterization of the major nuclear localization signal of the Borna disease virus phosphoprotein. J Gen Virol 80(Pt 1):97–100

    Article  CAS  PubMed  Google Scholar 

  • Scordel C, Huttin A, Cochet-Bernoin M, Szelechowski M, Poulet A, Richardson J, Benchoua A, Gonzalez-Dunia D, Eloit M, Coulpier M (2015) Borna disease virus phosphoprotein impairs the developmental program controlling neurogenesis and reduces human GABAergic neurogenesis. PLoS Pathog 11(4):e1004859. doi:10.1371/journal.ppat.1004859

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Siemetzki U, Ashok MS, Briese T, Lipkin WI (2009) Identification of RNA instability elements in Borna disease virus. Virus Res 144(1–2):27–34. doi:10.1016/j.virusres.2009.03.016

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sierra-Honigmann AM, Rubin SA, Estafanous MG, Yolken RH, Carbone KM (1993) Borna disease virus in peripheral blood mononuclear and bone marrow cells of neonatally and chronically infected rats. J Neuroimmunol 45(1–2):31–36

    Article  CAS  PubMed  Google Scholar 

  • Soares JC, Mann JJ (1997) The anatomy of mood disorders—review of structural neuroimaging studies. Biol Psychiatry 41:86–106

    Article  CAS  PubMed  Google Scholar 

  • Solbrig MV, Koob GF, Fallon JH, Lipkin WI (1994) Tardive dyskinetic syndrome in rats infected with Borna disease virus. Neurobiol Dis 1(3):111–119

    Article  CAS  PubMed  Google Scholar 

  • Solbrig MV, Fallon JH, Lipkin WI (1995) Behavioral disturbances and pharmacology of Borna disease. Curr Top Microbiol Immunol 190:93–101

    CAS  PubMed  Google Scholar 

  • Solbrig MV, Koob GF, Fallon JH, Reid S, Lipkin WI (1996a) Prefrontal cortex dysfunction in Borna disease virus (BDV)—infected rats. Biol Psychiatry 40(7):629–636

    Article  CAS  PubMed  Google Scholar 

  • Solbrig MV, Koob GF, Joyce JN, Lipkin WI (1996b) A neural substrate of hyperactivity in borna disease: changes in brain dopamine receptors. Virology 222(2):332–338. doi:10.1006/viro.1996.0430

    Article  CAS  PubMed  Google Scholar 

  • Solbrig MV, Koob GF, Joyce JN, Lipkin WI (1996c) A neural substrate of hyperactivity in Borna disease: changes in brain dopamine receptors. Virology 222(2):332–338

    Article  CAS  PubMed  Google Scholar 

  • Solbrig MV, Koob GF, Lipkin WI (1996d) Naloxone-induced seizures in rats infected with Borna disease virus. Neurology 46(4):1170–1171

    Article  CAS  PubMed  Google Scholar 

  • Solbrig MV, Koob GF, Lipkin WI (1998) Cocaine sensitivity in Borna disease virus-infected rats. Pharmacol Biochem Behav 59(4):1047–1052

    Article  CAS  PubMed  Google Scholar 

  • Solbrig MV, Koob GF, Lipkin WI (2002) Key role for enkephalinergic tone in cortico-striatal-thalamic function. Eur J Neurosci 16(9):1819–1822

    Article  PubMed  Google Scholar 

  • Sprankel H, Richarz K, Ludwig H, Rott R (1978) Behavior alterations in tree shrews (Tupaia glis, Diard 1820) induced by Borna disease virus. Med Microbiol Immunol 165(1):1–18

    Article  CAS  PubMed  Google Scholar 

  • Staeheli P, Rinder M, Kaspers B (2010) Avian bornavirus associated with fatal disease in psittacine birds. J Virol 84(13):6269–6275. doi:10.1128/JVI.02567-09

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stitz L, Planz O, Bilzer T (1998) Lack of antiviral effect of amantadine in Borna disease virus infection. Med Microbiol Immunol 186(4):195–200

    Article  CAS  PubMed  Google Scholar 

  • Suberbielle E, Stella A, Pont F, Monnet C, Mouton E, Lamouroux L, Monsarrat B, Gonzalez-Dunia D (2008) Proteomic analysis reveals selective impediment of neuronal remodeling upon Borna disease virus infection. J Virol 82(24):12265–12279. doi:10.1128/JVI.01615-08

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Trichtern V (1716) Pferd-Anatomie, oder Neu-auserlesen- vollkommen- verbessert- und ergänztes Roß-Artzeney-Buch. Adam Jonathan Felßecker, Franckfurt und Leipzig

    Google Scholar 

  • Tsujimura K, Mizutani T, Kariwa H, Yoshimatsu K, Ogino M, Morii Y, Inagaki H, Arikawa J, Takashima I (1999) A serosurvey of Borna disease virus infection in wild rats by a capture ELISA. J Vet Med Sci 61(2):113–117

    Article  CAS  PubMed  Google Scholar 

  • Volmer R, Monnet C, Gonzalez-Dunia D (2006) Borna disease virus blocks potentiation of presynaptic activity through inhibition of protein kinase C signaling. PLoS Pathog 2(3):e19. doi:10.1371/journal.ppat.0020019

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wagner K, Ludwig H, Paulsen J (1968) Fluorescence serological demonstration of Borna virus antigen. Berl Munch Tierarztl Wochenschr 81(19):395–396

    CAS  PubMed  Google Scholar 

  • Walker MP, Jordan I, Briese T, Fischer N, Lipkin WI (2000) Expression and characterization of the Borna disease virus polymerase. J Virol 74(9):4425–4428

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weissenbock H, Nowotny N, Caplazi P, Kolodziejek J, Ehrensperger F (1998) Borna disease in a dog with lethal meningoencephalitis. J Clin Microbiol 36(7):2127–2130

    CAS  PubMed  PubMed Central  Google Scholar 

  • Weissenbock H, Hornig M, Hickey WF, Lipkin WI (2000) Microglial activation and neuronal apoptosis in Bornavirus infected neonatal Lewis rats. Brain Pathol 10(2):260–272

    Article  CAS  PubMed  Google Scholar 

  • Weissenbock H, Bakonyi T, Sekulin K, Ehrensperger F, Doneley RJ, Durrwald R, Hoop R, Erdelyi K, Gal J, Kolodziejek J, Nowotny N (2009) Avian bornaviruses in psittacine birds from Europe and Australia with proventricular dilatation disease. Emerg Infect Dis 15(9):1453–1459. doi:10.3201/eid1509.090353

    Article  PubMed  PubMed Central  Google Scholar 

  • Werner-Keiss N, Garten W, Richt JA, Porombka D, Algermissen D, Herzog S, Baumgartner W, Herden C (2008) Restricted expression of Borna disease virus glycoprotein in brains of experimentally infected Lewis rats. Neuropathol Appl Neurobiol 34(6):590–602. doi:10.1111/j.1365-2990.2008.00940.x

    Article  CAS  PubMed  Google Scholar 

  • Wolff T, Heins G, Pauli G, Burger R, Kurth R (2006) Failure to detect Borna disease virus antigen and RNA in human blood. J Clin Virol 36(4):309–311. doi:10.1016/j.jcv.2006.05.005

    Article  CAS  PubMed  Google Scholar 

  • Wu YJ, Schulz H, Lin CC, Saar K, Patone G, Fischer H, Hubner N, Heimrich B, Schwemmle M (2013) Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors. Proc Natl Acad Sci U S A 110(5):1899–1904. doi:10.1073/pnas.1214939110

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yilmaz H, Helps CR, Turan N, Uysal A, Harbour DA (2002) Detection of antibodies to Borna disease virus (BDV) in Turkish horse sera using recombinant p40. Brief report. Arch Virol 147(2):429–435

    Article  CAS  PubMed  Google Scholar 

  • Zhang G, Kobayashi T, Kamitani W, Komoto S, Yamashita M, Baba S, Yanai H, Ikuta K, Tomonaga K (2003) Borna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1. J Virol 77(22):12243–12251

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zimmermann W, Durrwald R, Ludwig H (1994) Detection of Borna disease virus RNA in naturally infected animals by a nested polymerase chain reaction. J Virol Methods 46(2):133–143

    Article  CAS  PubMed  Google Scholar 

  • Zocher M, Czub S, Schulte-Monting J, de La Torre JC, Sauder C (2000) Alterations in neurotrophin and neurotrophin receptor gene expression patterns in the rat central nervous system following perinatal Borna disease virus infection. J Neurovirol 6:462–477

    Article  CAS  PubMed  Google Scholar 

  • Zwick W, Seifried O (1925) Uebertragbarkeit der seuchenhaften Gehirn- und Rückenmarksentzündung des Pferdes (Borna’schen Krankheit) auf kleine Versuchstiere (Kanninchen). Berl Tierarztl Wochenschr 41(9):129–132

    Google Scholar 

  • Zwick W, Seifried O, Witte J (1926) Experimentelle Untersuchungen über die seuchenhafte Gehirn- und Rückenmarksentzündung der Pferde (Bornasche Krankheit). Z Infkrankh Haustiere 30:42–136

    Google Scholar 

  • Zwick W, Seifried O, Witte J (1929) Weitere Beiträge zur Erforschung der Bornaschen Krankheit des Pferdes. Arch Wiss Prakt Teirheilkd 59:511–545

    Google Scholar 

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  1. Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, USA

    Mady Hornig

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    Mady Hornig

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    Carol Shoshkes Reiss

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Hornig, M. (2016). Borna Disease Virus. In: Reiss, C. (eds) Neurotropic Viral Infections. Springer, Cham. https://doi.org/10.1007/978-3-319-33133-1_13

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