Abstract
The effect of antacids on the pharmacokinetics of sulthiame are described. Also, potential pharmacodynamic interactions are highlighted.
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Antacids | Antacids containing magnesium trisilicate can decrease the oral bioavailability of sulthiame by up to 73 %, while antacids containing bismuth oxycarbonate and magnesium oxide can decrease the oral bioavailability of sulthiame by <15 %. To avoid problems, administration of sulthiame and antacids should be separated by at least 2 h [1] |
Reference
Naggar VF, Khalil SA. The in vitro adsorption of some antiepileptics on antacids. Pharmazie. 1978;33:593–5.
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Patsalos, P.N. (2016). Sulthiame. In: Antiepileptic Drug Interactions. Springer, Cham. https://doi.org/10.1007/978-3-319-32909-3_53
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DOI: https://doi.org/10.1007/978-3-319-32909-3_53
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Online ISBN: 978-3-319-32909-3
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