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Phenobarbital

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Abstract

The effect of BCNU, bleomycin, chloramphenicol, cisplatin, dicoumarol, disulfiram, ketogenic diet, pindolol, propoxyphene, teniposide, thioridazine, tipranavir/ritonavir, troleandomycin and vinblastine on the pharmacokinetics of phenobarbital are described. Also, potential pharmacodynamic interactions are highlighted.

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References

  1. Grossman SA, Sheidler VR, Gilbert MR. Decreased phenytoin levels in patients receiving chemotherapy. Am J Med. 1989;87:505–10.

    Article  CAS  PubMed  Google Scholar 

  2. Fincham RW, Schottelius DD. Decreased phenytoin levels in antineoplastic therapy. Ther Drug Monit. 1979;1:277–83.

    Article  CAS  PubMed  Google Scholar 

  3. Koup JR. Interaction of chloramphenicol with phenytoin and phenobarbital. A case report. Clin Pharmacol Ther. 1978;24:393–402.

    Article  Google Scholar 

  4. Cucinell SA, Conney AH, Sansur MS, Burns JJ. Drug interactions in man. I. Lowering effect of phenobarbital on plasma levels of bishydroxycoumarin (Dicoumarol®) and diphenylhydantoin (Dilantin®). Clin Pharmacol Ther. 1965;6:420–9.

    Article  CAS  PubMed  Google Scholar 

  5. Olesen OV. The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine. Arch Neurol. 1967;16:642–4.

    Article  CAS  PubMed  Google Scholar 

  6. Coppola G, Verrotti A, D’Aniello A, Arcieri S, Operto FF, Della Conte R, Ammendola E, Pascotto A. Valproic acid and phenobarbital blood levels during the first month of treatment with the ketogenic diet. Acta Neurol Scand. 2010;122:303–7.

    Article  CAS  PubMed  Google Scholar 

  7. Greendyke RM, Gulya A. Effect of pindolol administration on serum levels of thioridazine, haloperidol, phenytoin, and phenobarbital. J Clin Psychiatry. 1988;49:105–7.

    CAS  PubMed  Google Scholar 

  8. Hansen SB, Dam M, Brandt J, Hvidberg EF, Angelo H, Christensen MJ, Lous P. Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man. Acta Neurol Scand. 1980;61:357–67.

    Article  CAS  PubMed  Google Scholar 

  9. Baker DK, Relling MV, Pui CH, Christensen ML, Evans WE, Rodman JH. Increased teniposide clearance with concomitant anticonvulsant therapy. J Clin Oncol. 1992;10:311–5.

    CAS  PubMed  Google Scholar 

  10. Gay PE, Madsen JA. Interaction between phenobarbital and thioridazine. Neurology. 1983;33:1631–2.

    Article  CAS  PubMed  Google Scholar 

  11. Bonaro S, Calgagno A, Fontana S, D’Avolio A, Siccardi M, Gobbi F, Di Perri G. Clinically significant interaction between tipranavir ritonavir and phenobarbital in an HIV-infected patient. Clin Infect Dis. 2007;45:1654–5.

    Article  Google Scholar 

  12. Dravet C, Mesdjian E, Cenraud B, Roger J. Interaction between carbamazepine and triacetyloleandomycin. Lancet. 1997;1:810–1.

    Google Scholar 

  13. Bollini P, Riva R, Albani F, Ida N, Cacciari L, Bollini C, Baruzzi A. Decreased phenytoin level during antineoplastic therapy: a case report. Epilepsia. 1983;24:75–8.

    Article  CAS  PubMed  Google Scholar 

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Patsalos, P.N. (2016). Phenobarbital. In: Antiepileptic Drug Interactions. Springer, Cham. https://doi.org/10.1007/978-3-319-32909-3_45

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  • DOI: https://doi.org/10.1007/978-3-319-32909-3_45

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-32908-6

  • Online ISBN: 978-3-319-32909-3

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