Abstract
The effect of antacids, digoxin, meropenem, probenecid, oral contraceptives and warfarin on the pharmacokinetics of levetiracetam are described. Also, potential pharmacodynamic interactions are highlighted.
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Keywords
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Antacids | Calcium carbonate and aluminum hydroxide do not affect the pharmacokinetics of levetiracetam [1] |
Digoxin | Digoxin does not affect the pharmacokinetics of levetiracetam [2] |
Meropenem | Meropenem does not affect the pharmacokinetics of levetiracetam [3] |
Probenecid | Probenecid does not affect the pharmacokinetics of levetiracetam. However, the plasma level of its primary nonpharmacologically active metabolite, ucbLO59, increases 2.5-fold consequent to a 61 % decrease in tubular excretion [4] |
Oral contraceptives | Oral contraceptives do not affect the pharmacokinetics of levetiracetam [5] |
Warfarin | Warfarin does not affect the pharmacokinetics of levetiracetam [6] |
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Patsalos, P.N. (2016). Levetiracetam. In: Antiepileptic Drug Interactions. Springer, Cham. https://doi.org/10.1007/978-3-319-32909-3_41
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DOI: https://doi.org/10.1007/978-3-319-32909-3_41
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