Abstract
The pharmacokinetic characteristics of vigabatrin are described and the interaction effects of concomitant antiepileptic drugs on vigabatrin in terms of its pharmacokinetics and pharmacodynamics are highlighted.
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Armijo JA, Cuadrado A, Bravo J, Arteaga R. Vigabatrin serum concentration to dosage ratio: influence of age and associated antiepileptic drugs. Ther Drug Monit. 1997;19:491–8.
Brodie MJ, Mumford JP. Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group. Epilepsy Res. 1999;34:199–205.
Reidenberg P, Glue P, Banfield C, Colucci R, Meehan J, Rey E, Radwanski E, Nomeir A, Lim J, Lin C, Guillaume M, Affrime MB. Pharmacokinetic interaction studies between felbamate and vigabatrin. Br J Clin Pharmacol. 1995;40:157–60.
Stolarek I, Blacklaw J, Forrest G, Brodie MJ. Vigabatrin and lamotrigine in refractory epilepsy. J Neurol Neurosurg Psychiatry. 1994;57:921–4.
Perucca E, Baltes E, Ledent E. Levetiracetam: absence of pharmacokinetic interactions with other antiepileptic drugs (AEDs). Epilepsia. 2000;41(Suppl 6):150.
Spence SJ, Nakagawa J, Sankar R, Shields WD. Phenobarbital interferes with the efficacy of vigabatrin in treating infantile spasms in patients with tuberous sclerosis. Epilepsia. 2000;41 (Suppl 7):189.
Leach JP, Brodie MJ. Synergism with GABAergic drugs in refractory epilepsy. Lancet. 1994;343:1650.
Armijo JA, Arteaga R, Valdizan EM, Herranz JL. Coadministration of vigabatrin and valproate in children with refractory epilepsy. Clin Neuropharmacol. 1992;15:459–69.
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Patsalos, P.N. (2016). Vigabatrin. In: Antiepileptic Drug Interactions. Springer, Cham. https://doi.org/10.1007/978-3-319-32909-3_28
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DOI: https://doi.org/10.1007/978-3-319-32909-3_28
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