Abstract
The pharmacokinetic characteristics of pregabalin are described and the interaction effects of concomitant antiepileptic drugs on pregabalin in terms of its pharmacokinetics and pharmacodynamics are highlighted.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Summary of Product Characteristics: Brivaracetam (Briviact). UCB Pharma Ltd. Last update 21 Jan 2016.
Brodie MJ, Wilson EA, Wesche DL, Alvey CW, Randinitis EJ, Posvar EL, Hounslow NJ, Bron NJ, Gibson GL, Bockbrader HN. Pregabalin drug interaction studies: lack of effect on the pharmacokinetics of carbamazepine, phenytoin, lamotrigine, and valproate in patients with partial epilepsy. Epilepsia. 2005;46:1407–13.
Ben-Menachem E. Pregabalin pharmacology and its relevance to clinical practice. Epilepsia. 2004;45(Suppl 6):13–8.
Patsalos PN. Levetiracetam: pharmacology and therapeutics in the treatment of epilepsy and other neurological conditions. Rev Contemp Pharmacother. 2004;13:1–168.
May TW, Rambeck B, Neb R, Jurgens U. Serum concentrations of pregabalin in patients with epilepsy: the influence of dose, age, and comedication. Ther Drug Monit. 2007;29:789–94.
Summary of Product Characteristics: Pregabalin (Lyrica). Pfizer Ltd; 2011. Last update 27 Apr 2015.
Bockbrader HN, Burger PJ, Corrigan BW, Kugler AR, Knapp LE, Garofalo EA, Lalonde RL. Population pharmacokinetic (PK) analysis of commonly prescribed antiepileptic drugs (AEDs) co-administered with pregabalin (PGB) in adult patients with refractory partial seizures. Epilepsia. 2001;42(Suppl 7):84.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Patsalos, P.N. (2016). Pregabalin. In: Antiepileptic Drug Interactions. Springer, Cham. https://doi.org/10.1007/978-3-319-32909-3_19
Download citation
DOI: https://doi.org/10.1007/978-3-319-32909-3_19
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-32908-6
Online ISBN: 978-3-319-32909-3
eBook Packages: MedicineMedicine (R0)