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Perampanel

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Abstract

The pharmacokinetic characteristics of perampanel are described and the interaction effects of concomitant antiepileptic drugs on perampanel in terms of its pharmacokinetics and pharmacodynamics are highlighted.

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References

  1. Patsalos PN. The clinical pharmacology profile of the new antiepileptic drug perampanel: a novel noncompetitive AMPA receptor antagonist. Epilepsia. 2015;56:12–27.

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  2. Patsalos PN, Gougoulaki N, Sander JW. Perampanel serum concentrations in adults with epilepsy: effect of dose, age, sex and concomitant anti-epileptic drugs. Ther Drug Monit. 2016;38:358–64.

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  3. Gidal BE, Ferry J, Majid O, Hussein Z. Concentration-effect relationships with perampanel in patients with pharmacoresistant partial-onset seizures. Epilepsia. 2013;54:1490–7.

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© 2016 Springer International Publishing Switzerland

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Patsalos, P.N. (2016). Perampanel. In: Antiepileptic Drug Interactions. Springer, Cham. https://doi.org/10.1007/978-3-319-32909-3_15

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  • DOI: https://doi.org/10.1007/978-3-319-32909-3_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-32908-6

  • Online ISBN: 978-3-319-32909-3

  • eBook Packages: MedicineMedicine (R0)

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