Abstract
Congenital Central Hypoventilation Syndrome (CCHS) is a genetic disease, which affects the autonomic nervous system and in particular the breathing control. Patients show abnormal ventilatory response to both hypoxia and hypercapnia. Thus, mild or severe apnea crisis can occur, especially during sleep, and ventilatory assistance is required all the night long. Oxy-hemoglobin blood concentration (SpO2) is monitored by means of a pulse-oximeters and used to detect risk situations. These are signaled by the only commercial alarm systems available, that are the ones integrated in the ventilators and pulse-oximeters, which do not provide an adequate domiciliary assistance for CCHS patients. Therefore, we developed an assistive device which performs different multisensory stimulation strategies based on patient SpO2 level. The device efficacy, previously validated on healthy subjects, is under investigation in a population of patients affected by CCHS.
Preliminary results, obtained from five patients, show that the stimulations carried out by the device were more effective in terms of awakening in young adults than in children. In both cases, the SpO2 level recovery time after a desaturation was lowered by the multisensorial stimulation performed. Moreover, the quality of sleep was not affected by the device activity.
Overall, these results suggest the potential of the device as a tool to ameliorate CCHS patients domiciliary care, improving their quality of life.
E. Biffi and C.Piazza---equally contributing authors
An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-32703-7_260
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Biffi, E. et al. (2016). Preliminary Data on the Usability and Efficacy of an Assistive Device for the Congenital Central Hypoventilation Syndrome: An Observational Study. In: Kyriacou, E., Christofides, S., Pattichis, C. (eds) XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. IFMBE Proceedings, vol 57. Springer, Cham. https://doi.org/10.1007/978-3-319-32703-7_88
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DOI: https://doi.org/10.1007/978-3-319-32703-7_88
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