Spectral F Test for Detecting EEG Event Related Synchronization/Desynchronization Caused by Transcranial Magnetic Stimulation

  • Alexandre Cardozo Almeida
  • Mariana Aguiar Massote
  • Roberto Macoto Ichinose
  • Carlos Julio Tierra-Criollo
  • Antonio Mauricio Ferreira Leite Miranda de SaEmail author
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 57)


Event Related Synchronization/ Desynchronization (ERS/ERD) is a standard method to probe brain activity recorded in the Electroencephalogram (EEG). The Spectral F test (SFT) may be used for assessing ERS/ERD. Transcranial Magnetic Stimulation (TMS) is a painless method of nervous system activation that has been used as both research and diagnostic tools. The EEG analysis during TMS has helped to enlighten the mechanisms of this latter in brain activation. In this work, the SFT is applied for detecting EEG activations caused by TMS. Significant spectral changes were found to occur within the 1 to 30 Hz frequency band, confirming the findings of other authors who stimulated the sensoriomotor cortex. EEG changes statistically detected by STF can be useful to disclose brain information in normal functioning and disease. This method could also be used in other ways of brain activation, aside from TMS.


Electroencephalogram Transcranial Magnetic Stimulation Event-Related Desynchronization Event Related Synchronization Spectral F-Test 


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  1. 1.
    Pfurtscheller, G., and Aranibar, A. (1977). Event-related cortical desynchronization detected by power measurements of scalp EEG. ElectroencephalogrClinNeurophysiol 42, 817–826.Google Scholar
  2. 2.
    Pfurtscheller, G., and Lopes da Silva, F. (1999). Event-related EEG/MEG synchronization and desynchronization: basic principles. Clinical Neurophysiology 110, 1842–1857.Google Scholar
  3. 3.
    Durka, P.J., Zygierewicz, J., Klekowicz, H., Ginter, J., and Katarzyna J. Blinowska (2004). On the statistical significance of event-related EEG desynchronization and synchronization in the time-frequency plane. IEEE Trans Biomed Eng 51, 1167–1175.Google Scholar
  4. 4.
    Shumway, R.H. (1988), Applied Statistical Time Series Analysis, London: Prentice Hall.Google Scholar
  5. 5.
    Ramos, E.G., Zaeyen, E.J., Simpson, D.M., and Infantosi, A.M. (2000). Detecção da resposta auditiva no EEG de crianças utilizando técnicas no domínio da freqüência.pdf. Rev. Bras. Eng. Biomed 127–137.Google Scholar
  6. 6.
    Simpson, D.M., Tierra-Criollo, C.J., Leite, R.T., Zayen, E.J.B., and Infantosi, A.M. (2000). Objective Response Detection in an Electroencephalogram During Somatosensory Stimulation.pdf. Annals of Biomedical Engineering 28, 691–698.Google Scholar
  7. 7.
    Miranda de Sá, A.M.F.L., and Infantosi, A.F.C. (2008). A Statistical Test for Evaluating the Event-Related Synchronization/ Desynchronization and its Potential use in Brain-Computer-Interfaces. In IV Latin American Congress on Biomedical Engineering 2007, Bioengineering Solutions for Latin America Health, (Springer), pp. 1122–1126.Google Scholar
  8. 8.
    Chen, R., Cros, D., Curra, A., Di Lazzaro, V., Lefaucheur, J.-P., Magistris, M.R., Mills, K., Rösler, K.M., Triggs, W.J., Ugawa, Y., et al. (2008). The clinical diagnostic utility of transcranial magnetic stimulation: Report of an IFCN committee. Clinical Neurophysiology 119, 504–532.Google Scholar
  9. 9.
    Paus, P, Van Der Werf YD (2006). The neural response to transcranial magnetic stimulation of the human motor cortex. I. Intracortical and cortico-cortical contributions. Exp Brain Res 175(2), 231-245.Google Scholar
  10. 10.
    Miranda de Sá, A.M.F.L., Thiengo, H.C., Antunes, I.S., Simpson, D.M. (2009). Assessing Time-and Phase-Locked Changes in the EEG during Sensory Stimulation by Means of Spectral Techniques, IFMBE Proc. vol. 25/4, World Congress on Medical Physics and Biomedical Engineering, Munich, Germany, 2009, pp 2136-2139.Google Scholar
  11. 11.
    Fuggetta, G., Fiaschi, A., and Manganotti, P. (2005). Modulation of cortical oscillatory activities induced by varying single-pulse transcranial magnetic stimulation intensity over the left primary motor area: A combined EEG and TMS study. NeuroImage 27, 896–908.Google Scholar
  12. 12.
    Rosanova, M., Casali, A., Bellina, V., Resta, F., Mariotti, M., and Massimini, M. (2009). Natural Frequencies of Human Corticothalamic Circuits. Journal of Neuroscience 29, 7679–7685.Google Scholar
  13. 13.
    Rogasch, N.C., and Fitzgerald, P.B. (2013). Assessing cortical network properties using TMS-EEG. Human Brain Mapping 34, 1652–1669.Google Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Alexandre Cardozo Almeida
    • 1
  • Mariana Aguiar Massote
    • 1
  • Roberto Macoto Ichinose
    • 1
  • Carlos Julio Tierra-Criollo
    • 1
  • Antonio Mauricio Ferreira Leite Miranda de Sa
    • 1
    Email author
  1. 1.Biomedical Engineering ProgramFederal University of Rio de JaneiroRio de JaneiroBrazil

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