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Vitamin D in Chronic Kidney Disease pp 147–161Cite as

Vitamin D and Parathyroid Hormone Regulation in Chronic Kidney Disease

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Abstract

Parathyroid glands have a predominant role in mineral homeostasis. Calcium and vitamin D are two of the main regulators of the parathyroid function by virtue of the presence of the calcium-sensing receptor and vitamin D receptor in parathyroid cells. FGF23 also modulates parathyroid function. Chronic renal failure is characterized by derangements in factors involved in mineral metabolism that lead to the development of secondary hyperparathyroidism. This chapter reviews in depth the pathophysiology of secondary hyperparathyroidism, the function and regulation of the vitamin D receptor and the calcium-sensing receptor, as well as their roles in the development of parathyroid hyperplasia.

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Author information

Authors and Affiliations

  1. IIS-Fundación Jiménez-Díaz, Madrid, Spain

    María E. Rodríguez-Ortiz PhD

  2. Service of Nephrology, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    Mariano Rodríguez PhD

  3. Lipid and Atherosclerosis Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofia University Hospital/University of Cordoba, Córdoba, Spain

    Yolanda Almadén Peña PhD

  4. CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, University of Cordoba, Córdoba, Spain

    Yolanda Almadén Peña PhD

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  1. María E. Rodríguez-Ortiz PhD
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  2. Mariano Rodríguez PhD
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  3. Yolanda Almadén Peña PhD
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Correspondence to Mariano Rodríguez PhD .

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Editors and Affiliations

  1. Ramsay-Générale de Santé, Clinique du Landy, Saint Ouen, France

    Pablo A. Ureña Torres

  2. San Paolo Hospital, DiSS University of Milan, Milan, Italy

    Mario Cozzolino

  3. VU University Medical Center, Amsterdam, The Netherlands

    Marc G. Vervloet

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Rodríguez-Ortiz, M.E., Rodríguez, M., Peña, Y.A. (2016). Vitamin D and Parathyroid Hormone Regulation in Chronic Kidney Disease. In: Ureña Torres, P., Cozzolino, M., Vervloet, M. (eds) Vitamin D in Chronic Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-32507-1_7

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  • DOI: https://doi.org/10.1007/978-3-319-32507-1_7

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