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Use of New Vitamin D Analogs in Chronic Kidney Disease

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Book cover Vitamin D in Chronic Kidney Disease

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Abstract

Vitamin D is a common treatment against secondary hyperparathyroidism in renal patients. However, the rationale for the prescription of vitamin D sterols in chronic kidney disease (CKD) is rapidly increasing due to the coexistence of growing expectancies close to unsatisfactory evidences, such as the lack of randomized controlled trials (RCTs) proving the superiority of any vitamin D sterol against placebo on patient-centered outcomes, the scanty clinical data on head-to-head comparisons between the multiple vitamin D sterols currently available, the absence of RCTs confirming the crescent expectations on nutritional vitamin D pleiotropic effects even in CKD patients and the promising effects of vitamin D receptors activators (VDRA) against proteinuria and myocardial hypertrophy in diabetic CKD cohorts. The present chapter arguments these issues focusing on the opened questions that nephrologists should consider dealing with the prescription and the choice of a VDRA.

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Authors and Affiliations

  1. Renal and Dialysis Unit, San Paulo Hospital, Milan, Italy

    Riccardo Floreani MD

  2. Renal Division, Department of Health Sciences, San Paolo Hospital, University of Milan, Milan, Italy

    Mario Cozzolino MD, PhD, FERA

Authors
  1. Riccardo Floreani MD
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  2. Mario Cozzolino MD, PhD, FERA
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Correspondence to Mario Cozzolino MD, PhD, FERA .

Editor information

Editors and Affiliations

  1. Ramsay-Générale de Santé, Clinique du Landy, Saint Ouen, France

    Pablo A. Ureña Torres

  2. San Paolo Hospital, DiSS University of Milan, Milan, Italy

    Mario Cozzolino

  3. VU University Medical Center, Amsterdam, The Netherlands

    Marc G. Vervloet

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Floreani, R., Cozzolino, M. (2016). Use of New Vitamin D Analogs in Chronic Kidney Disease. In: Ureña Torres, P., Cozzolino, M., Vervloet, M. (eds) Vitamin D in Chronic Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-32507-1_30

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  • DOI: https://doi.org/10.1007/978-3-319-32507-1_30

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  • Online ISBN: 978-3-319-32507-1

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